gene

NDUFS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

10Outgoing

9Incoming

0Experiments

0Debates

Summary

NDUFS4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, biomarker for, implicated in. Associated with Alzheimer. Connected to 11 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NDUFS4
Function	The NDUFS4 gene encodes NDUFS4 Protein, a protein involved in various cellular processes relevant to neuronal function and survival.
Primary Expression	various brain regions, with notable expression in: - Cerebral cortex - Hippocampus - Basal gang
Pathways	Microrna
Ensembl ID	ENSG00000168907
GeneCards	NDUFS4
Human Protein Atlas	NDUFS4
Associated Diseases	Alzheimer
Interactions	COX15, COX4I1, COX7A1, COX8A, NDUFA12, NDUFA5
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NDUFS4 Gene

gene · 585 words

→

NDUFS4 Protein

protein · 1206 words

→

Pathway Diagram

graph TD
    NDUFS4["NDUFS4"]
    Alzheimer{"Alzheimer"}
    NDUFS4 -->|"associated_with"| Alzheimer
    HSPE1["HSPE1"]
    NDUFS4 -->|"biomarker_for"| HSPE1
    HSP90AA1["HSP90AA1"]
    NDUFS4 -->|"biomarker_for"| HSP90AA1
    ALZHEIMER["ALZHEIMER"]
    NDUFS4 -->|"associated_with"| ALZHEIMER
    GENES["GENES"]
    NDUFS4 -->|"biomarker_for"| GENES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NDUFS4 -->|"associated_with"| ALZHEIMER_S_DISEASE
    MICRORNAS["MICRORNAS"]
    NDUFS4 -->|"associated_with"| MICRORNAS
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    NDUFS4 -->|"associated_with"| IMMUNE_INFILTRATION
    OPTN["OPTN"]
    NDUFS4 -->|"biomarker_for"| OPTN
    Microrna(["Microrna"])
    NDUFS4 -->|"associated_with"| Microrna
    neurodegeneration["neurodegeneration"]
    NDUFS4 -->|"implicated_in"| neurodegeneration

Outgoing (10)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
GENES	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
Microrna	associated_with	pathway	0.60
MICRORNAS	associated_with	gene	0.60
HSPE1	biomarker_for	gene	0.60
HSP90AA1	biomarker_for	gene	0.60
OPTN	biomarker_for	gene	0.60

Incoming (9)

Source	Relation	Type	Str
COX15	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
COX7A1	inhibits	gene	0.60
COX8A	inhibits	gene	0.60
NDUFA12	inhibits	gene	0.60
NDUFA5	inhibits	gene	0.60
NDUFS1	inhibits	gene	0.60
NDUFA5	co_expressed_with	gene	0.50
NDUFS1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFS4 in their description or question text

No additional research found