gene

HSP90AA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP90AA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

710Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

10Experiments

4Debates

Summary

HSP90AA1 encodes Hsp90alpha, a molecular chaperone essential for protein folding and stability of client proteins including tau, alpha-synuclein, and LRRK2 in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	HSP90AA1
Full Name	Heat Shock Protein 90 Alpha Family Class A Member 1
Chromosome	14q32.31
Protein Type	Chaperone
Target Class	Chaperone
Function	Small molecule inhibitor binding to ATP-binding pocket of chaperone
Mechanism of Action	Small molecule inhibitor binding to ATP-binding pocket of chaperone
Druggability	Low (0.45)
Clinical Stage	Phase III
Molecular Weight	90 kDa
Amino Acids	854 aa
Exons	11
Pathways	NF-κB
UniProt ID	H0YJF5
NCBI Gene ID	3320
Ensembl ID	ENSG00000100425
OMIM	140571
GeneCards	HSP90AA1
Human Protein Atlas	HSP90AA1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	17-Dmag, 17-DMAG, Atbc, Bisphenol F, Chrysotoxine, Nvp-Auy922
Interactions	AHSA1, AKT, AKT1, AMYLOID, AND, ANXA2
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	HSP90-Tau Disaggregation Complex Enhancement HSP90-Tau Disaggregation Complex Enhancement
KG Connections	710 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSP90AA1 — AlphaFold H0YJF5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSP90AA1 Gene

gene · 1379 words

→

HSP90AA1 Protein

protein · 980 words

→

Pathway Diagram

graph TD
    HSP90AA1["HSP90AA1"]
    HSP90AA1 -->|"regulates"| HSP90_Tau_Disaggregation_Compl["HSP90-Tau Disaggregation Complex Enhancement"]
    HSP90AA1 -->|"target for"| Cancer["Cancer"]
    HSP90AA1 -->|"target for"| Fibrosis["Fibrosis"]
    HSP90AA1 -->|"inhibits"| Als["Als"]
    HSP90AA1 -->|"target for"| Ms["Ms"]
    HSP90AA1 -->|"target for"| Neuropathy["Neuropathy"]
    HSP90AA1 -->|"target for"| Carcinoma["Carcinoma"]
    h_637a53c9["h-637a53c9"] -->|"target for"| HSP90AA1
    h_0f00fd75["h-0f00fd75"] -->|"target for"| HSP90AA1
    HSPA1A["HSPA1A"] -->|"interacts"| HSP90AA1
    DNAJB1["DNAJB1"] -->|"interacts"| HSP90AA1
    FKBP5["FKBP5"] -->|"interacts"| HSP90AA1
    AKT["AKT"] -->|"target for"| HSP90AA1
    CASP3["CASP3"] -->|"target for"| HSP90AA1
    PI3K["PI3K"] -->|"target for"| HSP90AA1

Outgoing (446)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.95
Colorectal Cancer	involved_in	disease	0.90
ITGAV	activates	gene	0.90
protein_folding	participates_in	pathway	0.90
Als	activates	disease	0.85
Cancer	therapeutic_target	disease	0.85
ITGB5	interacts_with	gene	0.85
Triple-Negative Breast Cancer	associated_with	disease	0.80
HSPB1	regulates	protein	0.80
Client Proteins	regulates	protein	0.80
Drug Resistance	contributes_to	phenotype	0.80
HSPA1A	regulates	protein	0.80
Mapk	therapeutic_target	pathway	0.80
protein_stability	enhances	molecular_function	0.80
CANCER	therapeutic_target	gene	0.80
Apoptosis	therapeutic_target	pathway	0.80
CASP3	therapeutic_target	gene	0.80
AKT	therapeutic_target	gene	0.80
Chrysotoxine	interacts_with	compound	0.75
Alzheimer	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Apoptosis	activates	pathway	0.70
APOPTOSIS	therapeutic_target	gene	0.70
GENES	therapeutic_target	gene	0.70
ESR1	therapeutic_target	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
Complement	therapeutic_target	pathway	0.70
JUN	therapeutic_target	gene	0.70
HSP90-Tau Disaggregation Complex Enhancement	regulates	mechanism	0.70
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Copd	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Cancer	activates	disease	0.65
Longevity	activates	disease	0.65
Melanoma	regulates	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	causes	disease	0.65
Aging	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Diabetes	regulates	disease	0.65

Incoming (264)

Source	Relation	Type	Str
Nvp-Hsp990	inhibits	drug	0.95
Nvp-Auy922	inhibits	drug	0.95
17-Dmag	inhibits	drug	0.95
17-DMAG	inhibits	drug	0.90
NVP-HSP990	inhibits	drug	0.90
NVP-AUY922	inhibits	drug	0.90
h-637a53c9	targets	hypothesis	0.90
h-ca454967	targets_gene	hypothesis	0.90
SDA-2026-04-02-gap-tau-prop-20260402003221-H005	targets	hypothesis	0.90
PI3K	therapeutic_target	gene	0.90
Atbc	binds	compound	0.85
Bisphenol F	binds	compound	0.85
h-0f00fd75	targets	hypothesis	0.80
Chrysotoxine	targets	compound	0.80
AKT1	targets	gene	0.80
CASP3	targets	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
PI3K	regulates	gene	0.70
EGFR	targets	gene	0.70
ESR1	associated_with	gene	0.70
FKBP4	protein_interaction	gene	0.70
ESR1	targets	gene	0.70
CASP3	interacts_with	gene	0.70
BCL2	targets	gene	0.70
MAPK3	therapeutic_target	gene	0.70
APOPTOSIS	activates	gene	0.70
MAPT	regulates	gene	0.70
FKBP5	protein_interaction	gene	0.70
FKBP5	interacts_with	gene	0.61
HSPA1A	interacts_with	gene	0.61
DNAJB1	interacts_with	gene	0.61
ALZHEIMER	associated_with	gene	0.60
ROS	therapeutic_target	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
MICROGLIA	associated_with	gene	0.60
SYNAPSE	interacts_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
ROS	expressed_in	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
CANCER	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
HSC70	implicated_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HSP90-Tau Disaggregation Complex Enhancement	0.634	neurodegeneration	Tau propagation mechanisms and therapeut
HSP90-Tau Disaggregation Complex Enhancement	0.551	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Endothelial CD2AP knockdown effects on memory in male mice	validation	Alzheimer's disease	0.900	male mice	proposed	N/A
Amyloid plaque load analysis in triple-mutant mouse brains	exploratory	Alzheimer's disease	0.880	APP/PSEN1/GD3S-/- triple-trans	proposed	N/A
Reelin treatment rescue via ApoER2 in CD2AP mutant mice	validation	Alzheimer's disease	0.870	mice	proposed	N/A
MRI Phenotyping Method Concordance in Serbian AD Cohort	clinical	Alzheimer's disease	0.850	human patients	proposed	N/A
Endothelin-1 receptor A antagonist rescue in male CD2AP mice	validation	Alzheimer's disease	0.850	male mice	proposed	N/A
Endothelin-1 receptor A antagonist rescue experiment	validation	Alzheimer's disease	0.850	mice	proposed	N/A
In vivo BBB transport of LPS-carrying bEVs	validation	Alzheimer's disease	0.850	mice	proposed	N/A
Neuroimmune modulation and Aβ clearance mechanisms	exploratory	Alzheimer's disease	0.820	Microglia and astrocytes	proposed	N/A
16S rRNA sequencing of gut microbiome in PH-PS treated mice	exploratory	Alzheimer's disease	0.800	5×FAD transgenic mice	proposed	N/A
Competing endogenous RNA (ceRNA) network construction	exploratory	Alzheimer's disease	0.750	computational network analysis	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Gigantol: a principal bioactive constituent of Dendrobium species-multi-target m [PMID:40939944]	Shi S, Zhu C, Xu J, Sui Q, Zhu S, Zhang	Journal of ethnopharmacology	2026
Biomimetic cancer cell membrane-coated liposomal nanocarriers loaded with silibi [PMID:41585438]	Yao J, Sun Q, Zhang X, Yang D, Wu H et a	Mater Today Bio	2026
Exploring synergistic therapeutic potential of Erlotinib and artemisinin in non- [PMID:41672289]	Suleman F, Khan T, Alshehade SA, Ali M,	Clin Chim Acta	2026
Methyl-4-hydroxybenzoate induces osteoporosis via the AKT1/LC3B/Beclin1 autophag [PMID:41740552]	Fu F, Wang W, Li Y, Shi S, Huang J, Liu	Ecotoxicology and environmenta	2026
Chronic Thermal Stress During Early Zebrafish (Danio rerio) Development Induces [PMID:41793424]	Adzijovski M, Schultz AG, Oxley APA, Ber	Fish physiology and biochemist	2026
α-Glucosidase inhibitor: identifying key targets and mechanisms in type 2 diabet [PMID:41907120]	Garg SS, Vijh D, Gupta P, Gupta J, Malik	3 Biotech	2026
Elucidating the mechanisms of aristolochic acid-induced upper tract urothelial c [PMID:41780445]	Liu T, Yao Y, Xu Y, Zhang H, Sun L, Zhan	Computational biology and chem	2026
A Study on the Mechanism of Acetyl Tributyl Citrate-Induced Infertility Toxicity [PMID:41898778]	Sun X, Chen P, Han Y, Du Y, Sun S, Miu J	International journal of molec	2026
Investigating the clinical efficacy, safety and molecular mechanism of sulforaph [PMID:41275316]	Long J, Liao X, Tang Z, Han K, Chen J, W	BMC pharmacology & toxicology	2025
Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1/CHIP levels in Alzheimer's diseas [PMID:40116694]	Sordu P, Alaylıoğlu M, Samancı B, Bulu E	J Alzheimers Dis	2025
The chaperones HSP90AA1, HSP90AB1 and BAG3 are specifically distributed among hu [PMID:40436281]	Soriano-Herrador C, Ubeda-Banon I, Villa	Neurobiol Dis	2025
Mapping the pathogenic nexus: Gene overlap and protein interaction networks in A [PMID:40973403]	Chowdhury MR, Deepa VS, Raja VK	Adv Protein Chem Struct Biol	2025
The mechanism of probiotics in pregnancy outcomes in overweight or obese pregnan [PMID:40859213]	Zhong T, Sun J, Miao M, Sun G	BMC pregnancy and childbirth	2025
Chrysotoxine regulates ferroptosis and the PI3K/AKT/mTOR pathway to prevent cerv [PMID:39557107]	Zhou J, Guo Z, Peng X, Wu B, Meng Q, Lu	Journal of ethnopharmacology	2025
A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execut [PMID:38261660]	Iskandar K, Foo J, Liew AQX, Zhu H, Rama	Autophagy	2024
Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal [PMID:38247340]	Astillero-Lopez V, Villar-Conde S, Gonza	Brain pathology (Zurich, Switz	2024
Efficient analysis of toxicity and mechanisms of environmental pollutants with n [PMID:37858827]	Huang S	The Science of the total envir	2023
Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longe [PMID:35941759]	Yang S, Nie T, She H, Tao K, Lu F et al.	Autophagy	2023
Network pharmacology and molecular docking combined with widely targeted metabol [PMID:37150086]	Liu Y, Sun W, Shen N, Hao W, Xin H, Che	Computers in biology and medic	2023
Paeoniflorin protects against cisplatin-induced acute kidney injury through targ [PMID:36972781]	Zhang MY, Ma LJ, Jiang L, Gao L, Wang X,	Journal of ethnopharmacology	2023

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning HSP90AA1 in their description or question text

No additional research found