gene

SNCB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNCB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

1Hypotheses

0Analyses

16Outgoing

12Incoming

0Experiments

0Debates

Summary

Page for SNCB Gene

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🧬 Gene Info

Gene Symbol	SNCB
Full Name	Beta-Synuclein
Chromosome	5q35.2
Function	Beta-synuclein is expressed at high levels in the brain, particularly in presynaptic terminals where it performs several important functions:
Molecular Weight	14 kDa
Amino Acids	134 aa
UniProt ID	P37840
NCBI Gene ID	6622
Ensembl ID	ENSG00000100030
OMIM	163890
GeneCards	SNCB
Human Protein Atlas	SNCB
Inhibition of Fibril Formation	Beta-synuclein directly binds to alpha-synuclein, preventing its aggregation into toxic oligomers and fibrils
Heterooligomer Formation	The two proteins can form mixed oligomers that are less toxic than alpha-synuclein-only aggregates
Co-aggregation	When both proteins are present, they co-aggregate, diluting the overall toxicity of the inclusions
Associated Diseases	neurodegeneration
SciDEX Hypotheses	Ganglioside-rich extracellular vesicles preserve a
KG Connections	28 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SNCB — AlphaFold P37840 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SNCB["SNCB"]
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    SNCB -->|"expressed_in"| Traumatic_Brain_Injury
    SNCG(["SNCG"])
    SNCB -->|"expressed_in"| SNCG
    STMN1(["STMN1"])
    SNCB -->|"expressed_in"| STMN1
    GAP43(["GAP43"])
    SNCB -->|"expressed_in"| GAP43
    HSPE1(["HSPE1"])
    SNCB -->|"expressed_in"| HSPE1
    BRAIN_INJURY(["BRAIN INJURY"])
    SNCB -->|"expressed_in"| BRAIN_INJURY
    NDUFS6(["NDUFS6"])
    NDUFS6 -->|"expressed_in"| SNCB
    LDHB(["LDHB"])
    LDHB -->|"expressed_in"| SNCB
    MAPT(["MAPT"])
    MAPT -->|"expressed_in"| SNCB
    GENES(["GENES"])
    GENES -->|"expressed_in"| SNCB
    style SNCB fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (16)

Target	Relation	Type	Str
Traumatic Brain Injury	expressed_in	disease	0.65
BRAIN INJURY	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
LDHB	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
STMN1	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
NDUFS6	expressed_in	gene	0.60
Temporal Lobe	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Frontal Lobe	expressed_in	brain_region	0.55
Proteins	expressed_in	protein	0.50
SNCG	co_expressed_with	protein	0.50
STMN1	co_expressed_with	gene	0.50

Incoming (12)

Source	Relation	Type	Str
LDHB	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
NDUFS6	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
STMN1	expressed_in	gene	0.60
MAPT	co_expressed_with	gene	0.50
NDUFS6	co_expressed_with	gene	0.50
NDUFS6	co_mentioned	gene	0.40
GAP43	co_mentioned	gene	0.40
MAPT	co_mentioned	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Ganglioside-rich extracellular vesicles preserve alpha-synuc	0.582	neurodegeneration	Which specific CSF molecular components

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SNCB in their description or question text

No additional research found