concept

PENTOSE PHOSPHATE PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PENTOSE PHOSPHATE PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

6Outgoing

22Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PENTOSE PHOSPHATE PATHWAY
Key Genes/Proteins	AMPK
Related Diseases	CANCER

Pathway Diagram

graph TD
    PENTOSE_PHOSPHATE_PATHWAY["PENTOSE PHOSPHATE PATHWAY"]
    PENTOSE_PHOSPHATE_PATHWAY -->|"contributes to"| Pyrimidine_Biosynthesis["Pyrimidine Biosynthesis"]
    PENTOSE_PHOSPHATE_PATHWAY -->|"regulates"| Ferroptosis["Ferroptosis"]
    PENTOSE_PHOSPHATE_PATHWAY -->|"activates"| TCA_CYCLE["TCA CYCLE"]
    IDH2["IDH2"] -->|"upregulates"| PENTOSE_PHOSPHATE_PATHWAY
    G6PD["G6PD"] -->|"regulates"| PENTOSE_PHOSPHATE_PATHWAY
    PI3K_AKT["PI3K/AKT"] -->|"regulates"| PENTOSE_PHOSPHATE_PATHWAY
    Pi3K_Akt_Pathway["Pi3K/Akt Pathway"] -->|"modulates"| PENTOSE_PHOSPHATE_PATHWAY
    PI3K_AKT_Pathway["PI3K/AKT Pathway"] -->|"regulates"| PENTOSE_PHOSPHATE_PATHWAY
    PI3K_Akt_Pathway["PI3K/Akt Pathway"] -->|"regulates"| PENTOSE_PHOSPHATE_PATHWAY
    DCBLD1["DCBLD1"] -->|"activates"| PENTOSE_PHOSPHATE_PATHWAY

Outgoing (6)

Target	Relation	Type	Str
pyrimidine biosynthesis	promotes	pathway	0.90
Pyrimidine Biosynthesis	associated_with	pathway	0.90
Pyrimidine Biosynthesis	regulates	process	0.80
Ferroptosis	regulates	process	0.80
TCA CYCLE	activates	process	0.35
TCA CYCLE	regulates	process	0.35

Incoming (22)

Source	Relation	Type	Str
IDH2	upregulates	gene	0.90
IDH2	upregulates	entity	0.90
PI3K/AKT	regulates	entity	0.85
Pi3K/Akt Pathway	modulates	pathway	0.85
Metabolic Reprogramming	associated_with	process	0.85
PFKM	suppresses	protein	0.85
Glucose-6-Phosphate Dehydrogenase	regulates	enzyme	0.85
PI3K/Akt Pathway	regulates	pathway	0.80
G6PD	upregulates	gene	0.80
DCBLD1	activates	gene	0.80
PI3K/AKT	modulates	pathway	0.80
PI3K/AKT Pathway	regulates	pathway	0.80
GLYCOLYSIS	activates	process	0.50
PTEN	activates	gene	0.50
OXIDATIVE PHOSPHORYLATION	causes	process	0.35
CANCER	causes	disease	0.35
CANCER	activates	disease	0.35
AMPK	activates	gene	0.35
ELECTRON TRANSPORT CHAIN	regulates	process	0.35
FERROPTOSIS	activates	process	0.35
GLYCOLYSIS	regulates	process	0.35
NEURON	activates	cell_type	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PENTOSE PHOSPHATE PATHWAY in their description or question text

No additional research found