gene

HK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

1Analyses

50Outgoing

48Incoming

0Experiments

1Debates

Summary

HK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with ALS, Aging, Als. Connected to 74 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HK1
Full Name	Hexokinase 1
Chromosome	10p11.2
Protein Type	Enzyme
Function	Hexokinase 1 (HK1) is the first enzyme in glycolysis, catalyzing the phosphorylation of glucose to glucose-6-phosphate using ATP.
Amino Acids	908 aa
Pathways	Erk Signaling, Glycolysis, Mapk
UniProt ID	P19367
NCBI Gene ID	3099
Ensembl ID	ENSG00000156515
OMIM	142600
GeneCards	HK1
Human Protein Atlas	HK1
N-terminal glucose-binding domain	High-affinity binding (Km ~0.1 mM)
C-terminal catalytic domain	ATP binding and phosphate transfer
Associated Diseases	Als, Alzheimer, Cancer, Tumor
Known Drugs/Compounds	aducanumab
Interactions	AGING, AKT, AMPK, AND, APOPTOSIS, CANCER
KG Connections	152 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HK1 — AlphaFold P19367 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HK1["HK1"]
    VDAC["VDAC"]
    HK1 -->|"interacts with"| VDAC
    Cancer{"Cancer"}
    HK1 -->|"activates"| Cancer
    Tumor{"Tumor"}
    HK1 -->|"activates"| Tumor
    HK1 -->|"interacts with"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    HK1 -->|"interacts with"| Neurodegeneration
    Als{"Als"}
    HK1 -->|"activates"| Als
    Aging{"Aging"}
    HK1 -->|"interacts with"| Aging
    Ms{"Ms"}
    HK1 -->|"interacts with"| Ms
    HK1 -->|"associated with"| Cancer
    HK1 -->|"associated with"| Tumor
    ALS{"ALS"}
    HK1 -->|"activates"| ALS
    MTOR["MTOR"]
    HK1 -->|"activates"| MTOR
    FASN["FASN"]
    FASN -->|"activates"| HK1
    SRC["SRC"]
    SRC -->|"activates"| HK1
    PTEN["PTEN"]
    PTEN -->|"activates"| HK1
    PI3K["PI3K"]
    PI3K -->|"activates"| HK1
    MTOR -->|"activates"| HK1
    GENES["GENES"]
    GENES -->|"activates"| HK1
    G6PD["G6PD"]
    G6PD -->|"activates"| HK1
    HK2["HK2"]
    HK2 -->|"activates"| HK1
    HK2 -->|"interacts with"| HK1
    AKT["AKT"]
    AKT -->|"associated with"| HK1
    AMPK["AMPK"]
    AMPK -->|"associated with"| HK1
    FASN -->|"associated with"| HK1
    style HK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (104)

Target	Relation	Type	Str
VDAC	interacts_with	protein	0.95
MITOCHONDRIAL FUNCTION	modulates	entity	0.92
Glycolysis	involved_in	process	0.90
APOPTOSIS	regulates	entity	0.90
glucose_metabolism	participates_in	pathway	0.90
glycolysis	upregulates	process	0.85
NEURODEGENERATION	associated_with	entity	0.85
CANCER	associated_with	entity	0.82
AGING	associated_with	entity	0.80
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	causes	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Pancreatic Cancer	inhibits	disease	0.65
Aging	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Mitochondrial Function	activates	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
Glycolysis	interacts_with	pathway	0.60
AMPK	activates	gene	0.60
G6PD	activates	gene	0.60
CANCER	activates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
NEURODEGENERATION	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
AGING	interacts_with	gene	0.60
LDHB	activates	gene	0.60
HIF-1Α	activates	gene	0.60
LDHA	activates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
Mapk	regulates	pathway	0.60
Erk Signaling	regulates	pathway	0.60
Glycolysis	regulates	pathway	0.60
OLIGODENDROCYTE	causes	gene	0.60
AND	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
MYELIN	causes	gene	0.60

Incoming (48)

Source	Relation	Type	Str
TDP-43	targets	gene	0.80
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.80
HK2	expressed_in	gene	0.70
PTEN	activates	gene	0.60
PI3K	activates	gene	0.60
MTOR	activates	gene	0.60
HK2	activates	gene	0.60
HK2	interacts_with	gene	0.60
AKT	activates	gene	0.60
GLUT3	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
ERK	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
CANCER	inhibits	gene	0.60
ALZHEIMER	causes	gene	0.60
AGING	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
FASN	activates	gene	0.60
SRC	activates	gene	0.60
CD81	regulates	gene	0.60
GDI2	regulates	gene	0.60
MAG	regulates	gene	0.60
CANCER	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AKT	associated_with	gene	0.60
FASN	associated_with	gene	0.60
NDUFS7	regulates	gene	0.60
CAPZB	regulates	gene	0.60
PLCB1	regulates	gene	0.60
NDUFA4	regulates	gene	0.60
aducanumab	targets	drug	0.60
GENES	activates	gene	0.60
G6PD	activates	gene	0.60
GLUT1	activates	gene	0.60
DRP1	therapeutic_target	gene	0.60
NLRP3	therapeutic_target	gene	0.60
HIF	activates	gene	0.60
AMPK	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
PKM	activates	gene	0.60
LDHA	activates	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
LDHB	activates	gene	0.60
CANCER	co_discussed	gene	0.50
CD81	co_expressed_with	gene	0.50
GDI2	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

neurodegeneration | 2026-04-09 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning HK1 in their description or question text

No additional research found

HK1

Understanding Entity Pages

Summary

Wiki Pages (3)

HK1 — Hexokinase 1

SPHK1 — Sphingosine Kinase 1

SPHK1 Protein

Pathway Diagram

Outgoing (104)

Incoming (48)

Targeting Hypotheses (0)

Mentioning Analyses (1)

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

Experiments (0)

Related Papers (0)

Debates (1)

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

Related Research