concept

JAK-STAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK-STAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

582Connections

0Hypotheses

0Analyses

40Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	JAK-STAT
Key Genes/Proteins	AKT, BAX, BCL2, hematopoiesis, IL-6, immune function
Related Diseases	CANCER, Immune Dysregulation
Related Pathways	Dominant Negative Effects, Gain-Of-Function Variants

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    JAK_STAT["JAK-STAT"]
    JAK_STAT -->|"activates"| LIF["LIF"]
    JAK_STAT -->|"interacts"| Mtor["Mtor"]
    JAK_STAT -->|"interacts"| Nf__b["Nf-Kappab"]
    JAK_STAT -->|"interacts"| Mapk["Mapk"]
    AKT["AKT"] -->|"interacts"| JAK_STAT
    TNF["TNF"] -->|"activates"| JAK_STAT
    STAT3["STAT3"] -->|"target for"| JAK_STAT
    SOX2["SOX2"] -->|"activates"| JAK_STAT
    IL6["IL6"] -->|"activates"| JAK_STAT
    SRC["SRC"] -->|"activates"| JAK_STAT
    MICRORNAS["MICRORNAS"] -->|"regulates"| JAK_STAT
    Obesity["Obesity"] -->|"activates"| JAK_STAT
    Cancer["Cancer"] -->|"target for"| JAK_STAT

Outgoing (40)

Target	Relation	Type	Str
Immune Function	regulates	process	0.95
Th1-like cells	activates	cell_type	0.95
Th1-Like Cells	activates	cell_type	0.95
Hematopoiesis	regulates	process	0.95
Inborn Errors Of Immunity	associated_with	disease	0.92
hematopoiesis	regulates	gene	0.90
immune function	regulates	gene	0.90
Inflammation	regulates	process	0.90
Immunodeficiency	associated_with	disease	0.88
Primary Biliary Cholangitis	involved_in	disease	0.85
Liver Inflammation	mediates	process	0.85
Immune Dysregulation	associated_with	phenotype	0.85
Inflammation	associated_with	process	0.80
Caspase-3	activates	enzyme	0.80
LIF	activates	protein	0.70
Mapk	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
NEURONS	associated_with	concept	0.50
Epithelial Cell	inhibits	cell_type	0.50
RAPAMYCIN	activates	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
Stem Cell	activates	cell_type	0.50
Epithelial	activates	cell_type	0.50
Neuron	causes	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
STEM CELLS	activates	concept	0.50
T Cell	activates	cell_type	0.50
Epithelial	inhibits	cell_type	0.50
Astrocyte	expressed_in	cell_type	0.50
Microglia	therapeutic_target	cell_type	0.50
Stem Cell	therapeutic_target	cell_type	0.50
Astrocyte	therapeutic_target	cell_type	0.50
CELL PROLIFERATION	activates	concept	0.50
Invasion	activates	pathway	0.50
RAPAMYCIN	activates	drug	0.50
Microglia	activates	cell_type	0.50
IL-17	activates	concept	0.50
NEURONS	activates	concept	0.50

Incoming (542)

Source	Relation	Type	Str
JAK	activates	gene	1.00
STAT3	activates	gene	1.00
JAK	inhibits	gene	1.00
Als	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
Gain-Of-Function Variants	activates	mechanism	0.90
Dominant Negative Effects	inhibits	mechanism	0.90
Loss-Of-Function Variants	inhibits	mechanism	0.90
Als	activates	disease	0.90
AKT	interacts_with	gene	0.80
CANCER	activates	gene	0.80
CANCER	regulates	gene	0.80
AKT	regulates	gene	0.80
IL-6	activates	gene	0.80
PI3K	regulates	gene	0.80
INFLAMMATION	therapeutic_target	gene	0.80
CANCER	associated_with	gene	0.80
JAK	regulates	gene	0.80
Als	inhibits	disease	0.80
NF-ΚB	associated_with	gene	0.80
JAK	associated_with	gene	0.80
Als	regulates	disease	0.80
CYTOKINES	therapeutic_target	gene	0.80
Cancer	activates	disease	0.80
Cancer	regulates	disease	0.75
Tumor	activates	disease	0.70
Infection	activates	disease	0.70
CYTOKINES	activates	gene	0.70
IL-6	regulates	gene	0.70
Obesity	activates	disease	0.70
AKT	activates	gene	0.70
PI3K	activates	gene	0.70
Cancer	therapeutic_target	disease	0.70
TNF	activates	gene	0.70
AKT	associated_with	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
Leukemia	therapeutic_target	disease	0.70
STAT1	inhibits	gene	0.70
Cancer	associated_with	disease	0.70
STAT3	inhibits	gene	0.70
Cancer	inhibits	disease	0.70
Alzheimer	therapeutic_target	disease	0.70
CANCER	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
JAK	therapeutic_target	gene	0.70
Autoimmune	therapeutic_target	disease	0.70
INFLAMMATION	associated_with	gene	0.70
CANCER	inhibits	gene	0.70
TNF	activates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JAK-STAT in their description or question text

No additional research found