gene

IGF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

528Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IGF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 242 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	IGF1
Chromosome	12q23.2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	7.6 kDa
Amino Acids	70 aa
Exons	6
Pathways	PI3K, MAPK
Ensembl ID	ENSG00000117471
GeneCards	IGF1
Human Protein Atlas	IGF1
Class 1 transcripts	Include exon 1, encode the classic IGF-1A and IGF-1B isoforms
Class 2 transcripts	Include exon 2, produce variants with different N-terminal signal peptides
Ea isoform	The predominant brain isoform
Eb isoform	Less abundant, alternative splicing
Associated Diseases	ALS, Alzheimer, Ms
Known Drugs/Compounds	rapamycin
Interactions	ACHE, AGING, AKT, AKT1, ALZHEIMER, AMPK
KG Connections	528 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IGF1 Gene

gene · 1051 words

→

IGF1R Gene

gene · 983 words

→

Pathway Diagram

graph TD
    IGF1["IGF1"]
    IGF1 -->|"activates"| Ms["Ms"]
    IGF1 -->|"activates"| Fibrosis["Fibrosis"]
    IGF1 -->|"activates"| Ischemia["Ischemia"]
    IGF1 -->|"inhibits"| Als["Als"]
    IGF1 -->|"target for"| Cancer["Cancer"]
    IGF1 -->|"target for"| Carcinoma["Carcinoma"]
    IGF1 -->|"target for"| Tumor["Tumor"]
    PDGFRB["PDGFRB"] -->|"activates"| IGF1
    IGF1R["IGF1R"] -->|"activates"| IGF1
    EGR1["EGR1"] -->|"activates"| IGF1
    EGF["EGF"] -->|"activates"| IGF1
    AKT["AKT"] -->|"activates"| IGF1
    PON1["PON1"] -->|"target for"| IGF1
    PLIN1["PLIN1"] -->|"expressed in"| IGF1
    CD44["CD44"] -.biomarker for.-> IGF1
    RELB["RELB"] -->|"interacts"| IGF1

Outgoing (350)

Target	Relation	Type	Str
Oligodendrocyte	promotes	cell_type	0.88
senescence	regulates	process	0.85
myogenesis	promotes	process	0.85
Synaptic Plasticity	promotes	process	0.85
Myogenesis	promotes	process	0.85
Cardiovascular Health	regulates	process	0.80
Tumor	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
MMP2	inhibits	gene	0.70
ULK1	activates	gene	0.70
NFKB	activates	gene	0.70
PARP1	activates	gene	0.70
NFKB	regulates	gene	0.70
SQSTM1	activates	gene	0.70
VEGF	activates	gene	0.70
MICROGLIA	activates	cell_type	0.70
STING	targets	gene	0.70
PDGF	interacts_with	gene	0.70
RAGE	mediates	gene	0.70
VEGF	targets	gene	0.70
TAU	associated_with	gene	0.70
MMP9	associated_with	gene	0.70
SIRT1	targets	gene	0.70
TNF	targets	gene	0.70
AKT	regulates	gene	0.70
MAPK signaling	participates_in	pathway	0.70
CANCER	regulates	gene	0.70
MICROGLIA	regulates	cell_type	0.70
Alzheimer	regulates	disease	0.65
PDGF	increases	gene	0.65
STROKE	associated_with	gene	0.65
Neurodegeneration	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
TREM2	associated_with	gene	0.65
Hepatitis	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
PI3K	associated_with	gene	0.65
Als	contributes_to	disease	0.65
Alzheimer	expressed_in	disease	0.65
Huntington	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65

Incoming (178)

Source	Relation	Type	Str
Exercise	upregulates	process	0.85
IL30	inhibits	gene	0.80
HSP90	activates	gene	0.70
HIF1A	targets	gene	0.70
CAT	targets	gene	0.70
ASTROCYTE	associated_with	cell_type	0.70
GSK3B	interacts_with	gene	0.70
HIF1A	activates	gene	0.70
ATG5	activates	gene	0.70
ATG7	activates	gene	0.70
BECN1	activates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
APOE	regulates	gene	0.70
ACHE	activates	gene	0.70
AMPK	activates	gene	0.70
GENES	activates	gene	0.70
MICROGLIA	treats	cell_type	0.70
MICROGLIA	exacerbates	cell_type	0.70
HIPPOCAMPUS	activates	brain_region	0.65
AKT	associated_with	gene	0.65
FIBROSIS	regulates	disease	0.65
PPARG	activates	gene	0.60
ERK1	therapeutic_target	gene	0.60
PPARA	activates	gene	0.60
MAPK1	activates	gene	0.60
SLC2A1	activates	gene	0.60
P2RX7	contributes_to	gene	0.60
SERPINE1	contributes_to	gene	0.60
NINJ2	activates	gene	0.60
LNCRNA	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
RNA	contributes_to	gene	0.60
APP/PS1	expressed_in	gene	0.60
AD	regulates	gene	0.60
PI3K	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
AD	co_discussed	gene	0.60
ASTROCYTES	protects_against	cell_type	0.60
ASTROCYTES	expresses	cell_type	0.60
OVERVIEW	interacts_with	gene	0.60
ATG	regulates	gene	0.60
PON1	therapeutic_target	gene	0.60
PLIN1	expressed_in	gene	0.60
APP	treats	gene	0.60
GSK3B	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
EGF	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
FTO	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Sign	0.380	synaptic-biology	What determines the selectivity of compl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGF1 in their description or question text

No additional research found