gene

IGF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

538Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IGF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 242 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	IGF1
Chromosome	12q23.2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	7.6 kDa
Amino Acids	70 aa
Exons	6
Pathways	PI3K, MAPK
Ensembl ID	ENSG00000117471
GeneCards	IGF1
Human Protein Atlas	IGF1
Class 1 transcripts	Include exon 1, encode the classic IGF-1A and IGF-1B isoforms
Class 2 transcripts	Include exon 2, produce variants with different N-terminal signal peptides
Ea isoform	The predominant brain isoform
Eb isoform	Less abundant, alternative splicing
Associated Diseases	ALS, Alzheimer, Ms
Known Drugs/Compounds	rapamycin
Interactions	ACHE, AGING, AKT, AKT1, ALZHEIMER, AMPK
KG Connections	538 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IGF1 Gene

gene · 1051 words

→

IGF1R Gene

gene · 983 words

→

Pathway Diagram

graph TD
    IGF1["IGF1"]
    IGF1 -->|"activates"| Ms["Ms"]
    IGF1 -->|"activates"| Fibrosis["Fibrosis"]
    IGF1 -->|"activates"| Ischemia["Ischemia"]
    IGF1 -->|"inhibits"| Als["Als"]
    IGF1 -->|"target for"| Cancer["Cancer"]
    IGF1 -->|"target for"| Carcinoma["Carcinoma"]
    IGF1 -->|"target for"| Tumor["Tumor"]
    PDGFRB["PDGFRB"] -->|"activates"| IGF1
    IGF1R["IGF1R"] -->|"activates"| IGF1
    EGR1["EGR1"] -->|"activates"| IGF1
    EGF["EGF"] -->|"activates"| IGF1
    AKT["AKT"] -->|"activates"| IGF1
    PON1["PON1"] -->|"target for"| IGF1
    PLIN1["PLIN1"] -->|"expressed in"| IGF1
    CD44["CD44"] -.biomarker for.-> IGF1
    RELB["RELB"] -->|"interacts"| IGF1

Outgoing (353)

Target	Relation	Type	Str
Oligodendrocyte	promotes	cell_type	0.88
senescence	regulates	process	0.85
myogenesis	promotes	process	0.85
Synaptic Plasticity	promotes	process	0.85
Myogenesis	promotes	process	0.85
Cardiovascular Health	regulates	biological_process	0.80
Cancer	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
NFKB	activates	gene	0.70
STING	targets	gene	0.70
PARP1	activates	gene	0.70
ULK1	activates	gene	0.70
PDGF	interacts_with	gene	0.70
SQSTM1	activates	gene	0.70
VEGF	activates	gene	0.70
MMP9	associated_with	gene	0.70
VEGF	targets	gene	0.70
TNF	targets	gene	0.70
TAU	associated_with	gene	0.70
SIRT1	targets	gene	0.70
MMP2	inhibits	gene	0.70
NFKB	regulates	gene	0.70
MICROGLIA	activates	cell_type	0.70
RAGE	mediates	gene	0.70
MICROGLIA	regulates	cell_type	0.70
CANCER	regulates	gene	0.70
MAPK signaling	participates_in	pathway	0.70
AKT	regulates	gene	0.70
Aging	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Senescence	activates	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
PI3K	increases	gene	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Anxiety	activates	disease	0.65
Longevity	regulates	disease	0.65
Obesity	activates	disease	0.65
Cancer	expressed_in	disease	0.65
RAPAMYCIN	regulates	drug	0.65
Ms	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	contributes_to	disease	0.65
Ms	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Huntington	inhibits	disease	0.65

Incoming (185)

Source	Relation	Type	Str
Exercise	upregulates	process	0.85
IL30	inhibits	gene	0.80
ASTROCYTE	associated_with	cell_type	0.70
AMPK	activates	gene	0.70
BECN1	activates	gene	0.70
ATG7	activates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
HSP90	activates	gene	0.70
HIF1A	activates	gene	0.70
ATG5	activates	gene	0.70
CAT	targets	gene	0.70
HIF1A	targets	gene	0.70
GSK3B	interacts_with	gene	0.70
ACHE	activates	gene	0.70
APOE	regulates	gene	0.70
GENES	activates	gene	0.70
MICROGLIA	treats	cell_type	0.70
MICROGLIA	exacerbates	cell_type	0.70
AKT	increases	gene	0.65
FIBROSIS	regulates	disease	0.65
HIPPOCAMPUS	activates	brain_region	0.65
EGFR	contributes_to	gene	0.60
APP	treats	gene	0.60
GSK3B	associated_with	gene	0.60
EGFR	biomarker_for	gene	0.60
PI3K	activates	gene	0.60
GENES	contributes_to	gene	0.60
NEUROINFLAMMATION	expressed_in	gene	0.60
AND	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ASTROCYTE	protects_against	cell_type	0.60
ASTROCYTE	expresses	cell_type	0.60
GFAP	activates	gene	0.60
HMOX1	biomarker_for	gene	0.60
HSP90B1	activates	gene	0.60
PI3K	regulates	gene	0.60
EGFR	activates	gene	0.60
HSPA4	activates	gene	0.60
FOXO1	activates	gene	0.60
HSP90AA1	activates	gene	0.60
PRKACB	activates	gene	0.60
PIK3R1	activates	gene	0.60
P2RX7	contributes_to	gene	0.60
HMOX1	contributes_to	gene	0.60
SERPINE1	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	regulates	disease	0.60
AKT	associated_with	gene	0.60
PON1	therapeutic_target	gene	0.60
HMOX1	associated_with	gene	0.60
PLIN1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity