gene

PTGS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTGS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

712Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

The PTGS2 gene encodes cyclooxygenase-2 (COX-2), a key enzyme in prostaglandin synthesis that plays a critical role in neuroinflammation and neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS.

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🧬 Gene Info

Gene Symbol	PTGS2
Full Name	Prostaglandin-Endoperoxide Synthase 2
Aliases	COX-2
Chromosome	1q31.1
Protein Family	prostaglandin synthase family
Protein Type	Enzyme
Function	encodes a key enzyme in the prostaglandin biosynthesis pathway that plays a pivotal role in neuroinflammation and neurodegenerative disease pathogenesis.
Primary Expression	Constitutive
Molecular Weight	71 kDa
Exons	10
Pathways	NF-κB pathway, NF-κB, MAPK signaling, MAPK
UniProt ID	P35354
NCBI Gene ID	5743
Ensembl ID	ENSG00000073756
OMIM	600262
GeneCards	PTGS2
Human Protein Atlas	PTGS2
Associated Diseases	Aging, Als, Alzheimer, Cancer, Carcinoma
Interactions	ACSL4, ACTB, AKT, AKT1, AND, APOE
KG Connections	709 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PTGS2 — AlphaFold P35354 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PTGS2 - Prostaglandin-Endoperoxide Synthase 2

gene · 2509 words

→

PTGS2/COX-2 Protein - Cyclooxygenase-2

protein · 783 words

→

Pathway Diagram

graph TD
    PTGS2["PTGS2"] -->|"Associated With"| Carcinoma["Carcinoma"]
    PTGS2["PTGS2"] -->|"Associated With"| Tumor["Tumor"]
    PTGS2["PTGS2"] -->|"Interacts With"| Ms["Ms"]
    PTGS2["PTGS2"] -->|"Inhibits"| Cancer["Cancer"]
    PTGS2["PTGS2"] -->|"Activates"| Fibrosis["Fibrosis"]
    PTGS2["PTGS2"] -->|"Activates"| Als["Als"]
    PTGS2["PTGS2"] -->|"Therapeutic Target"| Inflammation["Inflammation"]
    PTGS2["PTGS2"] -->|"Therapeutic Target"| Stroke["Stroke"]
    DZSM["DZSM"] -->|"Regulates"| PTGS2["PTGS2"]
    SQSTM1["SQSTM1"] -->|"Associated With"| PTGS2["PTGS2"]
    TNF["TNF"] -->|"Associated With"| PTGS2["PTGS2"]
    ELAVL1["ELAVL1"] -->|"Associated With"| PTGS2["PTGS2"]
    GPX4["GPX4"] -->|"Associated With"| PTGS2["PTGS2"]
    style PTGS2 fill:#8d4900,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style Stroke fill:#b71c1c,color:#e0e0e0
    style DZSM fill:#00838f,color:#e0e0e0
    style SQSTM1 fill:#8d4900,color:#e0e0e0
    style TNF fill:#8d4900,color:#e0e0e0
    style ELAVL1 fill:#8d4900,color:#e0e0e0
    style GPX4 fill:#8d4900,color:#e0e0e0

Outgoing (364)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PTGS2	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:PTGS2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	0.95
CANCER	therapeutic_target	gene	0.90
GENES	therapeutic_target	gene	0.90
ferroptosis	biomarker_for	process	0.85
Inflammation	therapeutic_target	disease	0.85
RAGE	therapeutic_target	gene	0.80
INFLAMMATION	therapeutic_target	gene	0.80
Aging	therapeutic_target	disease	0.75
Prostate Cancer	therapeutic_target	disease	0.75
Hepatitis	therapeutic_target	disease	0.75
Carcinoma	associated_with	disease	0.75
Atherosclerosis	therapeutic_target	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Neutrophilic Inflammation	involved_in	process	0.75
Cancer	inhibits	disease	0.75
Hepatocellular Carcinoma	associated_with	disease	0.75
AKT	therapeutic_target	gene	0.70
Autophagy	associated_with	pathway	0.70
MMP9	expressed_in	gene	0.70
MMP9	therapeutic_target	gene	0.70
IL-6	therapeutic_target	gene	0.70
TNF-Α	therapeutic_target	gene	0.70
Apoptosis	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
CASP3	therapeutic_target	gene	0.70
Cardiovascular	interacts_with	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	regulates	disease	0.65
Aging	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Cancer	protects_against	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
ALS	protects_against	disease	0.65
Als	interacts_with	disease	0.65
Cardiac	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Fibrosis	associated_with	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Fibrosis	inhibits	disease	0.65
Cardiac	activates	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65

Incoming (348)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PTGS2	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:PTGS2	data_in	dataset_row	0.00
TMEM16F	regulates	gene	1.00
ds-83b31ef18d49	data_in	dataset	1.00
Hesperetin	regulates	drug	0.90
SQSTM1	associated_with	gene	0.70
GPX4	associated_with	gene	0.70
ELAVL1	associated_with	gene	0.70
IL6	interacts_with	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
ROS	associated_with	gene	0.70
TP53	therapeutic_target	gene	0.70
ATG	associated_with	gene	0.70
P62	associated_with	gene	0.70
FTH1	associated_with	gene	0.70
GENES	therapeutic_target	gene	0.70
TNF	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
DZSM	regulates	drug	0.70
COL1A1	associated_with	gene	0.70
TNF	therapeutic_target	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
P53	therapeutic_target	gene	0.70
TP53	associated_with	gene	0.70
PI3K	therapeutic_target	gene	0.70
JUN	associated_with	gene	0.70
NCOA4	associated_with	gene	0.70
IL6	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
TP53	interacts_with	gene	0.60
ICAM1	expressed_in	gene	0.60
MMP9	expressed_in	gene	0.60
CD4	therapeutic_target	gene	0.60
AKT1	associated_with	gene	0.60
FOS	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
RELA	associated_with	gene	0.60
MYC	associated_with	gene	0.60
EGF	associated_with	gene	0.60
BNIP3L	therapeutic_target	gene	0.60
CASP3	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
SLC7A11	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
JNK	inhibits	gene	0.60
BCL2	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity