concept

GLUT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

1Analyses

50Outgoing

46Incoming

0Experiments

1Debates

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💡 Concept Info

Name	GLUT3
Key Genes/Proteins	Actin, Akt, AKT, AMPK, AND, ANXA2
Related Diseases	Als, ALS, Alzheimer's disease
Related Pathways	Angiogenesis, Apoptosis

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLUT3["GLUT3"]
    GLUT3 -->|"modulates"| Glioblastoma_Invasion["Glioblastoma Invasion"]
    GLUT3 -->|"activates"| Tumor["Tumor"]
    GLUT3 -->|"activates"| Cancer["Cancer"]
    GLUT3 -->|"activates"| ALS["ALS"]
    GLUT3 -->|"activates"| Glioblastoma["Glioblastoma"]
    GLUT3 -->|"target for"| Als["Als"]
    PKM["PKM"] -->|"activates"| GLUT3
    FASN["FASN"] -->|"activates"| GLUT3
    LDHA["LDHA"] -->|"activates"| GLUT3
    HK1["HK1"] -->|"activates"| GLUT3
    HK2["HK2"] -->|"activates"| GLUT3
    HIF["HIF"] -->|"activates"| GLUT3
    AKT["AKT"] -->|"activates"| GLUT3
    AMPK["AMPK"] -->|"activates"| GLUT3

Outgoing (106)

Target	Relation	Type	Str
Bladder Cancer	associated_with	disease	0.85
High-Carbohydrate Diet	upregulates	drug	0.85
Glioblastoma Invasion	modulates	phenotype	0.80
Inflammation	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Als	protects_against	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Neuropathy	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Dementia	protects_against	disease	0.65
Diabetes	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
HIF-1Α	activates	gene	0.60
PI3K	activates	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Mtor	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
FN1	regulates	gene	0.60
GBP2	regulates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
Immune Response	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
Nf-Kb	inhibits	pathway	0.60
APOPTOSIS	biomarker_for	gene	0.60
GLUT4	biomarker_for	gene	0.60
GAP43	biomarker_for	gene	0.60
BAX/BCL2	biomarker_for	gene	0.60
Dna Methylation	protects_against	pathway	0.60
Apoptosis	biomarker_for	pathway	0.60
Epigenetic	protects_against	pathway	0.60
Neuron	biomarker_for	cell_type	0.60
Actin	protects_against	protein	0.60
Insulin	biomarker_for	protein	0.60
Bdnf	biomarker_for	protein	0.60
NF-KB	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
FLAVONOIDS	inhibits	gene	0.60
GLUT1	contributes_to	gene	0.60
G6PD	activates	gene	0.60
FASN	activates	gene	0.60
GLUT1	activates	gene	0.60

Incoming (46)

Source	Relation	Type	Str
h-075f1f02	targets_gene	hypothesis	0.90
GBM	expressed_in	gene	0.60
GLUT1	expressed_in	gene	0.60
GLUT1	associated_with	gene	0.60
FN1	regulates	gene	0.60
GLUT1	biomarker_for	gene	0.60
DEMENTIA	protects_against	gene	0.60
BDNF	biomarker_for	gene	0.60
DNA	protects_against	gene	0.60
CREB	biomarker_for	gene	0.60
AKT	expressed_in	gene	0.60
MAP2	biomarker_for	gene	0.60
AND	contributes_to	gene	0.60
FLAVONOIDS	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
PKM	activates	gene	0.60
FASN	activates	gene	0.60
LDHA	activates	gene	0.60
HK1	activates	gene	0.60
HK2	activates	gene	0.60
HIF	activates	gene	0.60
AKT	activates	gene	0.60
AMPK	activates	gene	0.60
GLUT1	activates	gene	0.60
AND	activates	gene	0.60
LDHB	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
SRC	activates	gene	0.60
G6PD	activates	gene	0.60
PTEN	activates	gene	0.60
MTOR	activates	gene	0.60
GENES	regulates	gene	0.60
GBM	regulates	gene	0.60
ASTROCYTE	activates	gene	0.60
PHIP	regulates	gene	0.60
ANXA2	regulates	gene	0.60
AND	regulates	gene	0.60
GBP2	regulates	gene	0.60
IL-1	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
GLUT4	interacts_with	gene	0.50
HMGCS2	co_discussed	gene	0.40
Tricaprilin Phase 3 ALTER-AD Study (NCT05809908)	references	clinical	0.40
cbs-psp-daily-action-plan	references	therapeutic	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.652

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does metabolic reprogramming (glucose metabolism shifts, brain insulin resis

closed · Rounds: 4 · Score: 0.73 · 2026-04-02

Related Research

Hypotheses and analyses mentioning GLUT3 in their description or question text

No additional research found