concept

LDHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

233Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	LDHA
Key Genes/Proteins	ABCA1, ACAT1, ACC, ACLY, ACSL5, Akt
Related Diseases	Aging, Als, ALS
Related Pathways	aerobic glycolysis

Pathway Diagram

graph TD
    LDHA["LDHA"]
    LDHA -->|"involved_in"| Glycolysis["Glycolysis"]
    LDHA -->|"activates"| Tumor["Tumor"]
    LDHA -->|"activates"| Cancer["Cancer"]
    LDHA -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    LDHA -->|"inhibits"| Inflammation["Inflammation"]
    LDHA -->|"inhibits"| ALS["ALS"]
    LDHA -->|"inhibits"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    LDHA -->|"activates"| Carcinoma["Carcinoma"]
    LDHA -->|"activates"| Als["Als"]
    LDHA -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    EEF2["EEF2"] -->|"binds"| LDHA
    HIF["HIF"] -->|"activates"| LDHA
    PI3K["PI3K"] -->|"activates"| LDHA
    HK2["HK2"] -->|"activates"| LDHA
    MTOR["MTOR"] -->|"activates"| LDHA
    SRC["SRC"] -->|"activates"| LDHA
    GENES["GENES"] -->|"activates"| LDHA
    HK1["HK1"] -->|"activates"| LDHA
    AMPK["AMPK"] -->|"activates"| LDHA
    G6PD["G6PD"] -->|"activates"| LDHA

Outgoing (148)

Target	Relation	Type	Str
h-b2ebc9b2	targeted_by	hypothesis	1.00
h-b701c493b0	targeted_by	hypothesis	1.00
lactate	regulates	pathway	0.95
Glycolysis	involved_in	process	0.90
bactericidal activity	promotes	phenotype	0.90
aerobic glycolysis	involved_in	pathway	0.90
lactate production	regulates	process	0.90
Lactate Production	mediates	process	0.85
Lactate Production	upregulates	process	0.80
unfolded protein response	participates_in	pathway	0.75
ASTROCYTES	activates	cell_type	0.70
ROS	activates	phenotype	0.70
ROS	regulates	phenotype	0.70
Glioblastoma	associated_with	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
ALS	associated_with	disease	0.65
ALS	inhibits	disease	0.65
astrocytes	expressed_in	cell_type	0.65
Tumor	associated_with	disease	0.65
Fibrosis	inhibits	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Tumor	activates	disease	0.65
Stroke	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	regulates	disease	0.65
Ms	inhibits	disease	0.65
GLYCOLYSIS	regulates	phenotype	0.65
PDK1	activates	gene	0.60
HK2	activates	gene	0.60
Mtor	activates	pathway	0.60
PDK3	activates	gene	0.60
E2F1	activates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Oxidative Phosphorylation	activates	pathway	0.60
CANCER	activates	gene	0.60
GLUT1	activates	gene	0.60
Apoptosis	inhibits	pathway	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
HK2	inhibits	gene	0.60
SLC2A1	activates	gene	0.60
Neuroinflammatory	inhibits	pathway	0.60

Incoming (85)

Source	Relation	Type	Str
h-immunity-c64967ab	relates_to	hypothesis	0.00
h-b701c493b0	targets	hypothesis	1.00
h-b2ebc9b2	targets	hypothesis	1.00
PDCD6	interacts_with	protein	0.95
h-5afacdfe	targets_gene	hypothesis	0.90
h-2a1a95c1	targets	hypothesis	0.90
Retinitis Pigmentosa progression	downregulates	phenotype	0.90
andrographolide	regulates	drug	0.85
PAL	upregulates	compound	0.80
EEF2	binds	gene	0.80
GFAP	regulates	gene	0.70
GLUTAMATE	causes	phenotype	0.70
LDHB	activates	gene	0.60
PTEN	activates	gene	0.60
CANCER	activates	gene	0.60
HIF-1Α	activates	gene	0.60
MICROGLIA	inhibits	gene	0.60
HK2	inhibits	gene	0.60
IFN	inhibits	gene	0.60
TNF	inhibits	gene	0.60
SPR	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
BRAIN INJURY	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
GAPDH	activates	gene	0.60
PFKFB3	inhibits	gene	0.60
IFN-Γ	inhibits	gene	0.60
AND	inhibits	gene	0.60
PKM	activates	gene	0.60
GBM	expressed_in	gene	0.60
IDH1	associated_with	gene	0.60
STROKE	inhibits	gene	0.60
GENES	inhibits	gene	0.60
AKT	inhibits	gene	0.60
MYC	inhibits	gene	0.60
FOXP3	inhibits	gene	0.60
RNA	inhibits	gene	0.60
RICTOR	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
AND	associated_with	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
LAG3	inhibits	gene	0.60
HIF	activates	gene	0.60
PI3K	activates	gene	0.60
HK2	activates	gene	0.60
MTOR	activates	gene	0.60
SRC	activates	gene	0.60
GENES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Immune atlas neuroinflammation analysis in neurodegeneration

Neuroinflammation | 2026-04-03 | 4 hypotheses Top: 0.646

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Comprehensive analysis of immune cell subtypes in neurodegeneration: microglia s

closed · Rounds: 4 · Score: 0.85 · 2026-04-03

Related Research

Hypotheses and analyses mentioning LDHA in their description or question text

No additional research found