gene

FASN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FASN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

354Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FASN is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with AD, AMI, ARM. Connected to 204 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FASN
Chromosome	1q25
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	273 kDa
Pathways	Akt, Lipid Metabolism, Mtor, Pi3K
Ensembl ID	ENSG00000169710
GeneCards	FASN
Human Protein Atlas	FASN
Associated Diseases	AD, Aging, AMI, ARM, Atherosclerosis, breast cancer
Interactions	ABCA1, ACACA, ACC, ACLY, ACOX1, ACSL4
KG Connections	354 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FASN Gene

gene · 1282 words

→

FASN Protein

protein · 1324 words

→

Pathway Diagram

graph TD
    FASN["FASN
Fatty Acid Synthase"] -->|"activates"| AKT["AKT/PI3K Pathway"]
    FASN -->|"activates"| AMPK["AMPK"]
    FASN -->|"activates"| Glycolysis["Glycolysis"]
    FASN -->|"activates"| HK1["HK1"]
    FASN -->|"activates"| G6PD["G6PD"]

    FASN -->|"inhibits"| Apoptosis["Apoptosis"]
    FASN -->|"inhibits"| BAX["BAX"]
    FASN -->|"inhibits"| Ferroptosis["Ferroptosis"]
    FASN -->|"inhibits"| ACSL4["ACSL4"]
    FASN -->|"inhibits"| Cholesterol["Cholesterol Synthesis"]

    AMPK -->|"activates"| FASN
    ACSL4 -->|"inhibits"| FASN

    FASN -->|"implicated in"| AD["Alzheimer's Disease"]
    FASN -->|"associated with"| Aging["Aging"]
    FASN -->|"activates"| Cancer["Cancer"]

    style FASN fill:#e74c3c,stroke:#c0392b,color:#e0e0e0
    style AKT fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style Ferroptosis fill:#f39c12,stroke:#e67e22,color:#e0e0e0
    style AD fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style Cancer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0

Outgoing (251)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
CANCER	activates	gene	1.00
Tumor	activates	disease	0.95
FATTY ACID SYNTHESIS	involved_in	entity	0.90
Lactation	involved_in	phenotype	0.85
hepatocellular carcinoma	promotes	disease	0.85
Lipid Synthesis	involved_in	process	0.80
Fatty Acid Synthesis	upregulates	process	0.80
Lactation Dysfunction	biomarker_for	phenotype	0.80
AKT	activates	gene	0.80
Tumor	inhibits	disease	0.75
Glycolysis	activates	pathway	0.70
GENES	activates	gene	0.70
Pi3K/Akt	activates	pathway	0.70
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Mtor	activates	pathway	0.70
MTOR	activates	gene	0.70
Lipid Metabolism	therapeutic_target	pathway	0.70
Als	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Pyroptosis	interacts_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Breast Cancer	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Aging	activates	disease	0.65
ALS	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Fibrosis	inhibits	disease	0.65
Colorectal Cancer	activates	disease	0.65
Aging	associated_with	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
Ischemia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Parkinson	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Nf-Κb	inhibits	pathway	0.60

Incoming (103)

Source	Relation	Type	Str
ZDHHC20	palmitoylates	gene	0.95
SNX8-TRIM28	ubiquitin-mediated degradation	protein	0.90
UBIQUITIN	regulates	protein	0.90
PTEN	activates	gene	0.70
PI3K	activates	gene	0.70
NF-ΚB	inhibits	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
AND	activates	gene	0.60
ACACA	regulates	gene	0.60
PKM2	methylates	gene	0.60
P53	inhibits	gene	0.60
RNA	inhibits	gene	0.60
MTOR	activates	gene	0.60
HK2	activates	gene	0.60
AKT	associated_with	gene	0.60
ALOX15	inhibits	gene	0.60
TNF	activates	gene	0.60
IL1B	activates	gene	0.60
PPARA	activates	gene	0.60
PI3K	therapeutic_target	gene	0.60
IL6	activates	gene	0.60
PPARG	therapeutic_target	gene	0.60
ALDH2	activates	gene	0.60
HMGCR	therapeutic_target	gene	0.60
PPAR	inhibits	gene	0.60
PER	expressed_in	gene	0.60
ACOX1	activates	gene	0.60
MIRNAS	activates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
LC3B	activates	gene	0.60
EP300	causes	gene	0.60
GENES	activates	gene	0.60
G6PD	activates	gene	0.60
TNF-Α	inhibits	gene	0.60
VESICLE TRAFFICKING	contributes_to	gene	0.60
PKM	activates	gene	0.60
GENES	contributes_to	gene	0.60
LDL	contributes_to	gene	0.60
CANCER	regulates	gene	0.60
PD-1	activates	gene	0.60
GLUT1	activates	gene	0.60
GASDERMIN	interacts_with	gene	0.60
ACC	activates	gene	0.60
ACLY	activates	gene	0.60
ACSL4	inhibits	gene	0.60
TNF	inhibits	gene	0.60
BAX	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FASN in their description or question text

No additional research found