Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NRF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NRF2 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 1652 entities in the SciDEX knowledge graph.
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| Gene Symbol | NRF2 |
| Chromosome | 2q31.2 |
| Protein Family | Cap'n'Collar (CNC) bZIP transcription factor |
| Function | Basal state: Keap1 homodimer binds NRF2 via the DLG and ETGE motifs, serving as a substrate adapter for the Cul3-RING ubiquitin E3 ligase complex. |
| Molecular Weight | 68 kDa |
| Amino Acids | 605 aa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Chaperone |
| GeneCards | NRF2 |
| Human Protein Atlas | NRF2 |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | 4-octyl itaconate, 4OI, ALGERNON2, Alpha-Tocopherol, Artesunate, ATORVASTATIN |
| Interactions | ABCG2, ACETYLCHOLINE, ACHE, ACOD1, ACSL4, Actin |
| KG Connections | 3450 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NRF2["NRF2 Transcription Factor"] -->|"Inhibited by"| KEAP1["KEAP1 Repressor"]
NRF2 -->|"Activates"| ARE["Antioxidant Response Element"]
NRF2 -->|"Regulates"| OX["Oxidative Stress Response"]
NRF2 -->|"Inhibits"| INFLAM["Inflammation"]
NRF2 -->|"Regulates"| NFKB["NF-kappaB Pathway"]
ARE -->|"Induces"| HMOX1["HMOX1"]
ARE -->|"Induces"| NQO1["NQO1"]
ARE -->|"Induces"| SOD["SOD"]
ARE -->|"Induces"| GCLC["GCLC"]
ARE -->|"Induces"| GCLM["GCLM"]
ARE -->|"Induces"| SRXN1["SRXN1"]
ARE -->|"Induces"| TXNRD1["TXNRD1"]
GCLC -->|"Synthesizes"| GSH["Glutathione"]
GCLM -->|"Synthesizes"| GSH
NRF2 -->|"Implicated in"| ND["Neurodegeneration"]
NRF2 -->|"Associated with"| CCRCC["Clear Cell RCC"]
style NRF2 fill:#1b5e20,color:#e0e0e0
style KEAP1 fill:#b71c1c,color:#e0e0e0
style ARE fill:#0d47a1,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | inhibits | disease | 1.00 |
| Als | activates | disease | 1.00 |
| AKT | activates | protein | 1.00 |
| ferroptosis | regulates | process | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Cardiac | activates | disease | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Mapk | inhibits | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Cancer | activates | disease | 1.00 |
| PARKINSON'S DISEASE | associated_with | disease | 1.00 |
| STROKE | associated_with | disease | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| SOD1 | associated_with | gene | 1.00 |
| Ferroptosis | regulates | pathway | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Aging | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Nf-Κb | regulates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| TMEM16F | regulates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| KEAP1 | regulates | gene | 1.00 |
| P62 | activates | protein | 1.00 |
| GPX4 | inhibits | gene | 1.00 |
| INFLAMMATION | activates | phenotype | 1.00 |
| ROS | activates | phenotype | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NF-KB | associated_with | protein | 1.00 |
| KEAP1 | inhibits | protein | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| FERROPTOSIS | inhibits | gene | 1.00 |
| ROS | regulates | gene | 1.00 |
| HO-1 | inhibits | gene | 1.00 |
| HO-1 | activates | gene | 1.00 |
| NF-ΚB | regulates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 1.00 |
| ROS | inhibits | gene | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| HO-1 | regulates | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| BCL-2 | activates | gene | 1.00 |
| PARKINSON | therapeutic_target | gene | 1.00 |
| KEAP1 | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| FERROPTOSIS | activates | gene | 0.98 |
| RNS | activates | compound | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| NRF2 failure lowers antioxidant reserve and permits recurren | 0.740 | neurodegeneration | What mechanisms drive the self-amplifyin |
| Endothelial NRF2 Activation as a Master Switch for Post-CA B | 0.689 | neurodegeneration | View |
| NRF2-KEAP1 Pathway Activation to Coordinate Multi-Layer Anti | 0.650 | - | Ferroptosis in ALS and motor neuron dise |
| HBOT at 1.5 ATA for 60 min induces hormetic response via Nrf | 0.640 | neurodegeneration | What are the optimal oxygen pressure, du |
| NRF2-Mediated Metabolic Reprogramming: HBOT as Direct NAMPT/ | 0.602 | neurodegeneration | View |
| oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation | 0.550 | neurodegeneration | What determines P2RY12 receptor expressi |
| NRF2 Activation to Counteract Oxidative Stress from RGS6 Def | 0.518 | neurodegeneration | Does RGS6 upregulation or D2 autorecepto |
| Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Dow | 0.517 | neuroinflammation | What causes IBA1 low/negative microglia |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680
immunology | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.784
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 5 · Score: 0.59 · 2026-04-16
closed · Rounds: 4 · Score: 0.80 · 2026-04-16
closed · Rounds: 4 · Score: 0.83 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 3 · Score: 0.68 · 2026-04-02
Hypotheses and analyses mentioning NRF2 in their description or question text
Score: 0.550 · neurodegeneration · 2026-04-21
## Mechanistic Overview oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation starts from the claim that modulati
Score: 0.518 · neurodegeneration · 2026-04-18
## Mechanistic Overview NRF2 Activation to Counteract Oxidative Stress from RGS6 Deficiency starts from the claim that m
Score: 0.517 · neuroinflammation · 2026-04-21
## Mechanistic Overview Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Downregulation via NRF2 starts from the