concept

YAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

700Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

YAP is a concept in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 389 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	YAP
Key Genes/Proteins	ACSL4, Actin, ADRA2A, AGING, AGO2, AKT
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Accelerated Fluid Flow, Akt
Linked Hypotheses	1 hypotheses

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    YAP["YAP"]
    YAP -->|"regulates"| Cardiovascular["Cardiovascular"]
    YAP -->|"regulates"| MMP9["MMP9"]
    YAP -->|"regulates"| MMP2["MMP2"]
    YAP -->|"activates"| Als["Als"]
    YAP -->|"activates"| Cancer["Cancer"]
    YAP -->|"activates"| Tumor["Tumor"]
    YAP -->|"activates"| Ms["Ms"]
    Hippo_pathway["Hippo pathway"] -->|"regulates"| YAP
    PPARGC1A["PPARGC1A"] -->|"activates"| YAP
    SRC["SRC"] -->|"activates"| YAP
    PIEZO1["PIEZO1"] -->|"activates"| YAP
    ET1["ET1"] -->|"activates"| YAP
    RHOC["RHOC"] -->|"activates"| YAP
    RAC1["RAC1"] -->|"activates"| YAP
    RAB7["RAB7"] -->|"activates"| YAP

Outgoing (385)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
CANCER	activates	gene	1.00
Breast Cancer	activates	disease	0.95
Non-Small-Cell Lung Cancer	associated_with	disease	0.90
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
Cell Growth	promotes	phenotype	0.88
Histone Acetylation	modulates	process	0.87
PLIN2	downregulates	gene	0.85
Als	activates	disease	0.85
neural stem cells	interacts_with	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
MYC	activates	gene	0.80
Tumor	inhibits	disease	0.75
Diabetic Kidney Disease	biomarker_for	disease	0.75
Cancer	regulates	disease	0.75
Cancer	associated_with	disease	0.75
Als	regulates	disease	0.75
Aging	activates	disease	0.75
Carcinoma	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
EGF	activates	gene	0.70
neural stem cells	expressed_in	cell_type	0.70
LATS1	regulates	gene	0.70
endothelial cells	regulates	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
Apoptosis	activates	pathway	0.70
macrophages	expressed_in	cell_type	0.70
Wnt	regulates	pathway	0.70
SRC	activates	gene	0.70
MTOR	therapeutic_target	gene	0.70
Mtor	therapeutic_target	pathway	0.70
Hippo signaling	participates_in	pathway	0.70
Autophagy	activates	pathway	0.70
AKT	activates	gene	0.70
Metastasis	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Apoptosis	inhibits	pathway	0.70
AKT	therapeutic_target	gene	0.70
Hippo Pathway	associated_with	pathway	0.70
Yap/Taz	inhibits	pathway	0.70
Yap/Taz	activates	pathway	0.70
MMP9	regulates	protein	0.68
MMP2	regulates	protein	0.68
Obesity	associated_with	disease	0.65
Ms	activates	disease	0.65
Schizophrenia	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Ms	associated_with	disease	0.65

Incoming (315)

Source	Relation	Type	Str
HIPPO	activates	gene	1.00
STING	interacts_with	gene	0.95
Hippo pathway	regulates	pathway	0.90
Calcium	activates	compound	0.85
Accelerated Fluid Flow	activates	mechanism	0.85
DAG1	binds	gene	0.80
PPARGC1A	activates	gene	0.80
TAZ	activates	gene	0.80
HIPPO	regulates	gene	0.80
HIPPO	associated_with	gene	0.80
PIEZO1	activates	gene	0.74
CANCER	associated_with	gene	0.70
TAZ	associated_with	gene	0.70
CANCER	activates	gene	0.70
CDH1	regulates	gene	0.70
APOPTOSIS	activates	gene	0.70
PI3K	activates	gene	0.70
RAS	activates	gene	0.70
KRAS	activates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
TAZ	inhibits	gene	0.70
EGFR	therapeutic_target	gene	0.70
ET1	activates	protein	0.64
SRC	activates	protein	0.64
RAC1	activates	gene	0.60
RHOC	activates	gene	0.60
BLM	activates	gene	0.60
CREB1	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
ENDOSOMES	activates	gene	0.60
GENES	associated_with	gene	0.60
BNIP3	activates	gene	0.60
CANCER	regulates	gene	0.60
ALS	expressed_in	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
MYC	associated_with	gene	0.60
JNK1	activates	gene	0.60
SCN5A	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PAH	associated_with	gene	0.60
BAX	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
PTEN	therapeutic_target	gene	0.60
AMPK	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
OCT4	regulates	gene	0.60
TLR	therapeutic_target	gene	0.60
DNA	associated_with	gene	0.60
BCL-2	therapeutic_target	gene	0.60
TBK1	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning YAP in their description or question text

No additional research found

YAP

Understanding Entity Pages

Summary

Wiki Pages (9)

YAP/TAZ Mechanoactivation Protocol for Neurodegeneration

YAP/TAZ Signaling Pathway in Neurodegeneration

YAP/TAZ (Hippo) Signaling in Neurodegeneration

YAP1 — Yes-Associated Protein 1

YAP1 Protein

YAP/TEAD Pathway Modulators for Neurodegeneration

PAC1 (ADCYAP1R1) Receptor Neurons

NYAP1 — Neuronal Tyrosine-Phosphorylated Adaptor

NYAP1 Protein