| Gene Symbol | ent-gene-c42d399b |
| Function | - VEGF-A: Primary isoform mediating angiogenesis and vascular permeability |
| VEGF-A | Primary isoform mediating angiogenesis and vascular permeability |
| VEGF-B | Regulates vascular maintenance and energy metabolism |
| VEGF-C/D | Lymphangiogenesis and lymphatic vessel development |
| Angiogenesis | Formation of new blood vessels in the brain |
| Blood-brain barrier modulation | Improved drug delivery potential |
| Neuroprotection | Direct effects on neuronal survival through VEGF receptor signaling |
| Cerebral blood flow enhancement | Improved perfusion of brain tissue[@zacchigna2021] |
| PI3K/Akt pathway | Mediates VEGF-induced endothelial cell survival |
| MAPK/ERK pathway | Controls endothelial cell proliferation |
| Notch signaling | Regulates vessel maturation and patterning[@tam2019] |
| [APP](/entities/app-protein)/PS1 mice | VEGF gene therapy improved cerebral blood flow and reduced amyloid burden[@yang2011] |
| 3xTg-AD mice | VEGF overexpression enhanced neurogenesis and cognitive function[@garcia2014] |
| In vitro | VEGF protected against amyloid-beta-induced neuronal toxicity[@jin2014] |
| 6-OHDA lesioned rats | VEGF gene therapy promoted dopaminergic neuron survival[@yasuhara2010] |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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