Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Receptor Tyrosine Kinase: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Receptor Tyrosine Kinase |
| Key Genes/Proteins | ACTB, AKT, APOPTOSIS, ATG14, AURKA, AUTOPHAGY |
| Related Diseases | Aging, Als, Arrhythmia, Breast Cancer, cancer |
Knowledge base pages for this entity
graph TD
AKT["AKT"] -->|"activates"| Receptor_Tyrosine_Kinase["Receptor Tyrosine Kinase"]
RAS["RAS"] -->|"activates"| Receptor_Tyrosine_Kinase["Receptor Tyrosine Kinase"]
Als["Als"] -->|"activates"| Receptor_Tyrosine_Kinase["Receptor Tyrosine Kinase"]
ERK["ERK"] -->|"activates"| Receptor_Tyrosine_Kinase["Receptor Tyrosine Kinase"]
style Receptor_Tyrosine_Kinase fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| RAS | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| ERK | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| CANCER | activates | gene | 0.90 |
| Als | therapeutic_target | disease | 0.80 |
| Cancer | therapeutic_target | disease | 0.80 |
| CANCER | regulates | gene | 0.80 |
| PI3K | activates | gene | 0.80 |
| Cancer | regulates | disease | 0.80 |
| APOPTOSIS | activates | gene | 0.80 |
| GENES | therapeutic_target | gene | 0.70 |
| EGF | activates | gene | 0.70 |
| Tumor | therapeutic_target | disease | 0.70 |
| CANCER | therapeutic_target | gene | 0.70 |
| ERK | inhibits | gene | 0.70 |
| Tumor | inhibits | disease | 0.70 |
| Carcinoma | activates | disease | 0.70 |
| Melanoma | therapeutic_target | disease | 0.70 |
| Als | regulates | disease | 0.70 |
| Tumor | activates | disease | 0.70 |
| DNA | therapeutic_target | gene | 0.60 |
| ERK | therapeutic_target | gene | 0.60 |
| BRAF | activates | gene | 0.60 |
| NF1 | activates | gene | 0.60 |
| Colorectal Cancer | activates | disease | 0.60 |
| Melanoma | activates | disease | 0.60 |
| MIRNAS | inhibits | gene | 0.60 |
| HDAC6 | inhibits | gene | 0.60 |
| TRPV4 | inhibits | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| BCL-2 | activates | gene | 0.60 |
| HMOX1 | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| Liver Cancer | activates | disease | 0.60 |
| Hepatocellular Carcinoma | activates | disease | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| MICRORNAS | regulates | gene | 0.60 |
| JAK | activates | gene | 0.60 |
| SRC | regulates | gene | 0.60 |
| Tumor | regulates | disease | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| Neurodegeneration | activates | disease | 0.60 |
| CREB | activates | gene | 0.60 |
| OVERVIEW | therapeutic_target | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| SRC | activates | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Receptor Tyrosine Kinase in their description or question text
No additional research found