gene 1,708 words KG: NEURD1
Contents

NEURD1 - N-terminal EGF Like Domain Calcium Binding Protein 1

🧬 Gene Info
Gene SymbolNEURD1
Full NameN-terminal EGF Like Domain Calcium Binding Protein 1
AliasesGene profile for NEURD1
Chromosome19p13.3
Functionis a neuronal protein characterized by the presence of EGF-like domains and calcium-binding motifs.
Subcellular Localizationand function ### Splice Variants Multiple NEURD1 isoforms have been identified
GeneCardsNEURD1
Human Protein AtlasNEURD1
N-terminal signal peptideDirects secretion and membrane targeting
Calcium-binding EF-hand domainsCharacteristic sequence motifs that confer calcium-sensing capability
C-terminal regionRegulatory sequences affecting protein localization and function
Full-length isoformContains all functional domains
Shorter isoformsAlternative splicing generates variants with different domain compositions
Tissue-specific variantsBrain-enriched and peripheral tissue variants
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (11)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (11)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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