gene

ALDH1L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALDH1L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

0Experiments

0Debates

Summary

A gene referenced in 119 knowledge graph relationships. Key connections: provides_data_for ds-f2c28aed24a7 (dataset); data_in ds-f2c28aed24a7 (dataset); expressed_in astrocyte (cell_type).

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🧬 Gene Info

Gene Symbol	ALDH1L1
Full Name	Aldehyde Dehydrogenase 1 Family Member L1
Chromosome	3q21.3
Protein Type	Enzyme
Function	is a folate-metabolizing enzyme that catalyzes the oxidation of 10-formyltetrahydrofolate to tetrahydrofolate in the mitochondrial folate pathway.
Primary Expression	the liver and brain, particularly in astrocytes where it serves as a specific marker for mature astrocytes
Molecular Weight	99 kDa
Amino Acids	902 aa
UniProt ID	O75459
NCBI Gene ID	108
Ensembl ID	ENSG00000135917
OMIM	600182
GeneCards	ALDH1L1
Human Protein Atlas	ALDH1L1
Full-length ALDH1L1 (902 aa)	The canonical mitochondrial enzyme
Associated Diseases	Als, Frontotemporal Dementia, Glioma, Neuroinflammation, Tauopathy, Tumor
Interactions	ALZHEIMER, AMYLOID, APP/PS1, ASC, ASTROCYTE, ASTROCYTES
KG Connections	121 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ALDH1L1

gene · 2961 words

→

ALDH1L1 Protein

protein · 772 words

→

Pathway Diagram

flowchart TD
    A["ALDH1L1"] --> B["Astrocyte Marker"]
    A --> C["Folate Metabolism"]
    A --> D["One-Carbon Metabolism"]
    A --> E["Lipid Metabolism"]
    B --> F["Astrocyte Function"]
    C --> G["DNA Synthesis"]
    D --> G
    E --> H["Neurotrophic Support"]
    F --> H
    H --> I["Neuronal Survival"]
    G --> I
    E --> J["APOE Processing"]

Outgoing (108)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ALDH1L1	data_in	dataset_row	0.00
ds-f2c28aed24a7	provides_data_for	dataset	1.00
astrocyte	expressed_in	cell_type	0.80
GFAP	expressed_in	gene	0.70
ASTROCYTE	expressed_in	gene	0.70
Als	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	inhibits	disease	0.65
astrocytes	expressed_in	cell_type	0.65
Dementia	activates	disease	0.65
Als	activates	disease	0.65
Tumor	implicated_in	disease	0.65
Glioma	implicated_in	disease	0.65
ALS	expressed_in	disease	0.65
Tauopathy	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
DLK2	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
SYNAPSE	activates	gene	0.60
PARKINSON	activates	gene	0.60
NOTCH1	expressed_in	gene	0.60
VIMENTIN	expressed_in	gene	0.60
SOX2	expressed_in	gene	0.60
Ependymal	expressed_in	cell_type	0.60
CD8	associated_with	gene	0.60
CD4	associated_with	gene	0.60
TAU	associated_with	gene	0.60
IBA1	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
Pericyte	activates	cell_type	0.60
Oligodendrocyte	expressed_in	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
Microglia	expressed_in	cell_type	0.60
App	expressed_in	protein	0.60
DEMENTIA	associated_with	gene	0.60
ASTROCYTE	biomarker_for	gene	0.60
ASTROCYTES	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
Immune Response	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
ASTROCYTES	implicated_in	gene	0.60
APP/PS1	activates	gene	0.60
MICROGLIA	activates	gene	0.60

Incoming (20)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ALDH1L1	data_in	dataset_row	0.00
ds-f2c28aed24a7	data_in	dataset	1.00
AQP4	expressed_in	gene	0.60
GFAP	biomarker_for	gene	0.60
SOX2	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
NESTIN	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
DLK2	expressed_in	gene	0.60
VIMENTIN	expressed_in	gene	0.60
NOTCH1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ROS	activates	gene	0.60
NOTCH	expressed_in	gene	0.60
FTLD	associated_with	gene	0.60
TAUOPATHY	associated_with	gene	0.60
MERTK	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ALDH1L1 in their description or question text

No additional research found