gene

PDK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

178Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Transdiagnostic Proteomic Changes in Neurodegeneration

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🧬 Gene Info

Gene Symbol	PDK1
Function	Recent advances in proteomics have revealed remarkable convergence in protein alterations across distinct neurodegenerative diseases
Pathways	Cell Cycle, Differentiation, Glycolysis, Mitosis, Pi3K/Akt
GeneCards	PDK1
Human Protein Atlas	PDK1
Increased amyloid-related proteins	Elevated Aβ1-40, Aβ1-42 in cerebrospinal fluid (CSF)
Lipid metabolism alterations	Changes in apolipoproteins and lipid transport proteins
Synaptic protein reductions	Decreased synaptophysin, PSD95
Inflammatory marker elevations	Increased IL-6, TNF-α, C-reactive protein
Tau pathology acceleration	Higher CSF tau and p-tau levels
Accelerated cognitive decline	More rapid progression to dementia
Enhanced α-synuclein pathology	Increased Lewy body burden
Alterations in lipid metabolism	Similar to AD patterns
Immune activation signatures	Elevated microglial markers
White matter integrity reduction	Enhanced white matter lesion load
Associated Diseases	Aging, Als, Carcinoma, Cirrhosis, Infection, Ms
Interactions	AGING, AKT, AKT1, AND, APOPTOSIS, AUTOPHAGY
KG Connections	178 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Transdiagnostic Proteomic Changes in Neurodegeneration

gene · 960 words

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Pathway Diagram

graph TD
    PDK1["PDK1"] -->|"regulates"| ADAM17["ADAM17"]
    PDK1["PDK1"] -->|"activates"| Cirrhosis["Cirrhosis"]
    PDK1["PDK1"] -->|"activates"| Carcinoma["Carcinoma"]
    PDK1["PDK1"] -->|"activates"| Ms["Ms"]
    PDK1["PDK1"] -->|"activates"| Als["Als"]
    PDK1["PDK1"] -.->|"inhibits"| Cardiovascular["Cardiovascular"]
    EGF["EGF"] -->|"activates"| PDK1["PDK1"]
    CYP3A4["CYP3A4"] -->|"activates"| PDK1["PDK1"]
    SOD2["SOD2"] -->|"associated"| PDK1["PDK1"]
    CAT["CAT"] -->|"associated"| PDK1["PDK1"]
    style PDK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (107)

Target	Relation	Type	Str
AKT1	phosphorylates	gene	0.90
Pi3K/Akt Pathway	inhibits	pathway	0.85
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Pi3K/Akt	therapeutic_target	pathway	0.70
ADAM17	regulates	gene	0.70
Differentiation	regulates	pathway	0.70
AKT	activates	gene	0.70
AKT	regulates	gene	0.70
Glycolysis	activates	pathway	0.70
Als	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Infection	implicated_in	disease	0.65
Ischemia	inhibits	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Aging	implicated_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Breast Cancer	regulates	disease	0.65
Cirrhosis	associated_with	disease	0.65
Ms	activates	disease	0.65
Cirrhosis	activates	disease	0.65
Aging	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
ALS	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Hypertension	inhibits	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Circadian Rhythm	inhibits	pathway	0.60
Glycolysis	regulates	pathway	0.60
CIRCADIAN RHYTHM	inhibits	gene	0.60
PI3K	regulates	gene	0.60
STAT3	activates	gene	0.60
Lipid Metabolism	implicated_in	pathway	0.60
Epigenetic	implicated_in	pathway	0.60
Apoptosis	implicated_in	pathway	0.60
CYP1A2	activates	gene	0.60
Oxidative Phosphorylation	inhibits	pathway	0.60
HK2	regulates	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
Apoptosis	activates	pathway	0.60

Incoming (71)

Source	Relation	Type	Str
Theranekron	upregulates	drug	0.95
h-2a1a95c1	targets	hypothesis	0.90
CANCER	therapeutic_target	gene	0.70
PI3K	activates	gene	0.70
EGF	activates	gene	0.70
AKT	activates	gene	0.70
EGFR	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
LDHA	activates	gene	0.60
AND	activates	gene	0.60
C-MYC	activates	gene	0.60
GLUT1	activates	gene	0.60
FOXO1	activates	gene	0.60
PI3K	interacts_with	gene	0.60
AKT1	activates	gene	0.60
PGK1	regulates	gene	0.60
GAPDH	regulates	gene	0.60
TKT	regulates	gene	0.60
FBP1	regulates	gene	0.60
TP53	regulates	gene	0.60
BMAL1	activates	gene	0.60
CLOCK	inhibits	gene	0.60
YAP	activates	gene	0.60
ERK	therapeutic_target	gene	0.60
AND	interacts_with	gene	0.60
AKT	implicated_in	gene	0.60
CHKA	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
HIPPO	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
PTEN	activates	gene	0.60
PERK	implicated_in	gene	0.60
CYP3A4	activates	gene	0.60
SOD2	associated_with	gene	0.60
CAT	associated_with	gene	0.60
BAX	associated_with	gene	0.60
SPR	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
ERK	activates	gene	0.60
CCL2	activates	gene	0.60
CYP1A2	activates	gene	0.60
APOPTOSIS	implicated_in	gene	0.60
CIRCADIAN RHYTHM	inhibits	gene	0.60
AGING	inhibits	gene	0.60
MYC	activates	gene	0.60
CANCER	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDK1 in their description or question text

No additional research found