gene 731 words KG: VEGFA
Contents

VEGFA — Vascular Endothelial Growth Factor A

🧬 Gene Info
Gene SymbolVEGFA
Full NameVascular Endothelial Growth Factor A
AliasesPage for VEGFA Protein
FunctionVEGF exerts its effects by binding to receptor tyrosine kinases (VEGFR-1/Flt-1 and VEGFR-2/KDR/Flk-1) on endothelial cells and other cell types.
Molecular Weight24 kDa
PathwaysAkt, Autophagy, Mapk, Oxidative Stress, Pi3K
Ensembl IDENSG00000112715
GeneCardsVEGFA
Human Protein AtlasVEGFA
Associated DiseasesAD, Aging, ALI, Als, Alzheimer, AMI
Known Drugs/Compoundsquercetin
InteractionsACTB, AGGF1, AKT, AKT1, ALS, ALZHEIMER
SciDEX HypothesesSpinal Vascular Unit Breakdown as Universal Driver
KG Connections964 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Axonal RNA Transport Reconstitution
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
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Related Analyses (8)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (8)

ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: interacts_with
AGGF1 Gene - Angiogenic Factor
gene · KG edge: activates
AKT1 Gene
gene · KG edge: therapeutic_target
ALDH1A1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

IDH1 therapeutic_target VEGFA
VEGFA therapeutic_target MDM4
VEGFA therapeutic_target APOB
VEGFA therapeutic_target SF3B1
VEGFA therapeutic_target MET
VEGFA therapeutic_target SMARCA4
VEGFA therapeutic_target TERT
VEGFA therapeutic_target JUN
VEGFA therapeutic_target EEF1A1
VEGFA therapeutic_target MCL1

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