gene 2,185 words KG: EGF
Contents

EGF Gene

🧬 Gene Info
Gene SymbolEGF
Full NameEpidermal Growth Factor
AliasesEpidermal Growth Factor gene
Chromosome4q25
Functionis a type I transmembrane protein that can be proteolytically cleaved at multiple sites to release the mature growth factor.
Molecular Weight6.2 kDa
Amino Acids53 aa
Exons24
PathwaysMAPK, PI3K
UniProt IDP01133
NCBI Gene ID1167
Ensembl IDENSG00000138798
OMIM131530
GeneCardsEGF
Human Protein AtlasEGF
Associated DiseasesAging, Als, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsActin, AKT, AKT1, AKT1S1, ALDH1L1, ALZHEIMER'S DISEASE
KG Connections1006 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Retinal Vascular Microcirculation Rescue
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Glial Glycocalyx Remodeling Therapy
Score: 0.65
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61

Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (15)

AMBRA1 Gene
gene · KG edge: interacts_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
adam17
gene · KG edge: implicated_in
ALDH1L1
gene · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: regulates

Knowledge Graph (12 edges)

EGF regulates tyrosine_phosphorylation
NRF2 activates EGF
EGF activates EGFR
ATF6 interacts_with EGF
OPTN interacts_with EGF
CASP3 interacts_with EGF
AKT1 interacts_with EGF
CALCOCO2 interacts_with EGF
CGAS interacts_with EGF
CFTR interacts_with EGF

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