concept

ENDOSOMES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

537Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ENDOSOMES is a concept in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Aging, Als. Connected to 253 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ENDOSOMES
Key Genes/Proteins	Actin, AGING, AKT, ALS2, ALZHEIMER, ALZHEIMER DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Amyloid

Pathway Diagram

graph TD
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    ENDOSOMES -->|"expressed in"| Als["Als"]
    ENDOSOMES -->|"expressed in"| Ms["Ms"]
    ENDOSOMES -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ENDOSOMES -->|"expressed in"| Dementia["Dementia"]
    ENDOSOMES -->|"activates"| Tumor["Tumor"]
    ENDOSOMES -->|"regulates"| Aging["Aging"]
    C9ORF72["C9ORF72"] -->|"binds"| ENDOSOMES
    ATM["ATM"] -->|"expressed in"| ENDOSOMES
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| ENDOSOMES
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"interacts"| ENDOSOMES
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"] -->|"interacts"| ENDOSOMES
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"interacts"| ENDOSOMES
    C9ORF72_REPEAT_EXPANSION["C9ORF72 REPEAT EXPANSION"] -->|"expressed in"| ENDOSOMES
    CHMP2B["CHMP2B"] -->|"expressed in"| ENDOSOMES
    OPTN["OPTN"] -->|"expressed in"| ENDOSOMES

Outgoing (312)

Target	Relation	Type	Str
ALS	causes	disease	0.75
Ataxia	associated_with	disease	0.75
Als	interacts_with	disease	0.75
EGF	activates	gene	0.70
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Parkinson	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Ms	interacts_with	disease	0.65
Als	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	regulates	disease	0.65
Als	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Chronic Pain	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Opioid	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Ms	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Parkinson	regulates	disease	0.65
Ftd	causes	disease	0.65
Ms	causes	disease	0.65
Ftd	regulates	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Stroke	transports	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Dementia	regulates	disease	0.65
Als	transports	disease	0.65

Incoming (225)

Source	Relation	Type	Str
C9ORF72	interacts_with	protein	0.90
C9ORF72	binds	gene	0.90
C9ORF72	interacts_with	gene	0.74
ATM	expressed_in	protein	0.70
C9ORF72 REPEAT EXPANSION	expressed_in	gene	0.60
OPTN	expressed_in	gene	0.60
AND	associated_with	gene	0.60
DMSO	activates	gene	0.60
VESICLE TRAFFICKING	interacts_with	gene	0.60
LYSOSOMAL BIOGENESIS	interacts_with	gene	0.60
RAB7	interacts_with	gene	0.60
CHMP2B	expressed_in	gene	0.60
NBR1	interacts_with	gene	0.60
EXOSOMES	associated_with	gene	0.60
MAP1LC3	activates	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
ATG	activates	gene	0.60
MTOR	activates	gene	0.60
SORL1	interacts_with	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
AKT	activates	gene	0.60
EGF	activates	gene	0.60
APOE3	regulates	gene	0.60
MTOR	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
OGT	activates	gene	0.60
RAC1	inhibits	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
LAMP1	inhibits	gene	0.60
RHOA	inhibits	gene	0.60
APP	inhibits	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
APP	interacts_with	gene	0.60
LRP10	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APP	activates	gene	0.60
SRC	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
IDO1	inhibits	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
LRP1	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
APOE4	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 7 hypotheses Top: 0.533

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning ENDOSOMES in their description or question text

No additional research found