gene

ELP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

17Outgoing

10Incoming

0Experiments

0Debates

Summary

Elongator acetyltransferase complex subunit 3 - tRNA modification and neurodevelopment

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🧬 Gene Info

Gene Symbol	ELP3
Full Name	Elongator Subunit 3
Aliases	Elongator acetyltransferase complex subunit 3
Chromosome	9q31.3
Protein Family	Elongator family, GNAT superfamily
Primary Expression	the brain during development and in adulthood, with particular enrichment in regions associated with higher cognitive functions
Gene Type	Protein-coding
Pathways	Autophagy
UniProt ID	Q9BYB4
NCBI Gene ID	55187
Ensembl ID	ENSG00000120656
OMIM	611023
GeneCards	ELP3
Human Protein Atlas	ELP3
tRNA acetylation	Modifies wobble position uridine (cmnm5U34) in tRNA
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ATG12, ATG16L1, ATG5, AUTOPHAGY, CANCER, Elongator
KG Connections	27 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ELP3 — AlphaFold Q9BYB4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ELP3 Gene

gene · 1376 words

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Pathway Diagram

graph TD
    ELP3["ELP3"]
    PAK1["PAK1"]
    ELP3 -->|"acetylates"| PAK1
    Glioblastoma{"Glioblastoma"}
    ELP3 -->|"activates"| Glioblastoma
    Cancer{"Cancer"}
    ELP3 -->|"activates"| Cancer
    Als{"Als"}
    ELP3 -->|"activates"| Als
    Tumor{"Tumor"}
    ELP3 -->|"activates"| Tumor
    GBM["GBM"]
    ELP3 -->|"activates"| GBM
    RAC1["RAC1"]
    ELP3 -->|"activates"| RAC1
    ELP3 -->|"activates"| PAK1
    ATG12["ATG12"]
    ELP3 -->|"activates"| ATG12
    Autophagy(["Autophagy"])
    ELP3 -->|"activates"| Autophagy
    ATG5["ATG5"]
    ELP3 -->|"activates"| ATG5
    ATG16L1["ATG16L1"]
    ELP3 -->|"activates"| ATG16L1
    RB1CC1["RB1CC1"]
    RB1CC1 -->|"interacts with"| ELP3
    ATG5 -->|"activates"| ELP3
    ATG16L1 -->|"activates"| ELP3
    RAC1 -->|"activates"| ELP3
    PAK1 -->|"activates"| ELP3
    GBM -->|"activates"| ELP3
    CANCER["CANCER"]
    CANCER -->|"activates"| ELP3
    P21["P21"]
    P21 -->|"activates"| ELP3
    GLIOBLASTOMA["GLIOBLASTOMA"]
    GLIOBLASTOMA -->|"activates"| ELP3
    AND["AND"]
    AND -->|"activates"| ELP3
    style ELP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
PAK1	acetylates	protein	0.70
RNA polymerase II	interacts_with	protein	0.70
cell cycle	regulates	biological_process	0.70
cell growth	inhibits	phenotype	0.70
Glioblastoma	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
ATG5	activates	gene	0.60
ATG16L1	activates	gene	0.60
Autophagy	activates	pathway	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
GBM	activates	gene	0.60
RAC1	activates	gene	0.60
PAK1	activates	gene	0.60
ATG12	activates	gene	0.60

Incoming (10)

Source	Relation	Type	Str
Elongator	interacts_with	protein	0.80
RB1CC1	interacts_with	gene	0.80
GBM	activates	gene	0.60
RAC1	activates	gene	0.60
PAK1	activates	gene	0.60
CANCER	activates	gene	0.60
P21	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
ATG5	activates	gene	0.60
ATG16L1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ELP3 in their description or question text

No additional research found