gene

ATG9A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG9A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

176Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATG9A is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, interacts with. Associated with ALS, Als, Cancer. Connected to 145 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG9A
Aliases	ATG9A protein
Chromosome	2p24.1
Protein Family	ATG9 family
Function	Membrane Source: Provides lipids for phagophore expansion
Subcellular Localization	Trans-Golgi network, Endosomes, Plasma membrane, Autophagosomes
Molecular Weight	139 kDa
Amino Acids	790 aa
Pathways	Autophagy, Mitochondrial Function, Mitophagy, Nf-Κb, Stem Cell
UniProt ID	Q7Z418
GeneCards	ATG9A
Human Protein Atlas	ATG9A
Trans-Golgi network (TGN)	Primary reservoir for ATG9A under basal conditions [10]
Endosomes	ATG9A-positive endosomes deliver membrane to autophagosomes [11]
Plasma membrane	Constitutive endocytosis and recycling [12]
Associated Diseases	Ms
Interactions	AND, ARAF, ATG, ATG101, ATG12, ATG13
KG Connections	176 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ATG9A — AlphaFold Q7Z418 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG9A["ATG9A"]
    ATG9A -->|"co-localizes"| SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
    ATG9A -->|"regulates"| Als["Als"]
    ATG9A -.protects against.-> Tumor["Tumor"]
    ATG9A -.protects against.-> Ms["Ms"]
    ATG9A -->|"activates"| Cancer["Cancer"]
    ATG9A -->|"regulates"| Parkinson["Parkinson"]
    RAB5["RAB5"] -->|"regulates"| ATG9A
    PARKIN["PARKIN"] -->|"regulates"| ATG9A
    PINK1["PINK1"] -->|"regulates"| ATG9A
    PTEN["PTEN"] -->|"regulates"| ATG9A
    RAB7A["RAB7A"] -->|"regulates"| ATG9A
    BCL2["BCL2"] -->|"regulates"| ATG9A
    TNF["TNF"] -->|"target for"| ATG9A
    FIP200["FIP200"] -->|"interacts"| ATG9A
    SYNAPTOPHYSIN -->|"expressed in"| ATG9A
    ATG["ATG"] -->|"expressed in"| ATG9A

Outgoing (116)

Target	Relation	Type	Str
AUTOPHAGY	associated_with	gene	1.00
Mitophagosome Formation	involved_in	process	0.90
SYNAPTOPHYSIN	co-localizes	gene	0.90
Autophagosome Formation	involved_in	process	0.85
Autophagy	activates	pathway	0.80
Autophagy	regulates	pathway	0.80
Als	activates	disease	0.75
Als	regulates	disease	0.75
Cancer	regulates	disease	0.75
AUTOPHAGY	regulates	gene	0.70
CANCER	regulates	gene	0.70
Autophagy	interacts_with	pathway	0.70
LC3	interacts_with	gene	0.70
LC3	activates	gene	0.70
Autophagy	associated_with	pathway	0.70
Ms	associated_with	disease	0.65
Als	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Infection	activates	disease	0.65
Pancreatic Cancer	regulates	disease	0.65
Infection	protects_against	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	protects_against	disease	0.65
Als	protects_against	disease	0.65
Parkinson	interacts_with	disease	0.65
Parkinson	regulates	disease	0.65
Tumor	protects_against	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
MYC	activates	gene	0.60
CDK12	activates	gene	0.60
ATG3	activates	gene	0.60
ATG7	activates	gene	0.60
CDK4	activates	gene	0.60
ATG16L1	activates	gene	0.60
CANCER	interacts_with	gene	0.60
ARAF	activates	gene	0.60
Metastasis	inhibits	pathway	0.60
BECLIN1	activates	gene	0.60
ATG12	activates	gene	0.60
RAB5	regulates	gene	0.60
PI3K	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ATG12	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG16L1	regulates	gene	0.60
ULK1	causes	gene	0.60

Incoming (60)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	0.80
RAB5	regulates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
MITOPHAGY	regulates	gene	0.60
AND	interacts_with	gene	0.60
TBK1	regulates	gene	0.60
LC3	interacts_with	gene	0.60
GPX4	regulates	gene	0.60
ATG5	regulates	gene	0.60
AND	inhibits	gene	0.60
TLR4	activates	gene	0.60
UVRAG	activates	gene	0.60
TNFR1	protects_against	gene	0.60
ATG	interacts_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
APOPTOSIS	protects_against	gene	0.60
RAB7A	regulates	gene	0.60
BCL2	regulates	gene	0.60
TNF	therapeutic_target	gene	0.60
FIP200	interacts_with	gene	0.60
SYNAPTOPHYSIN	expressed_in	gene	0.60
RAB5	activates	gene	0.60
BECN1	inhibits	gene	0.60
BNIP3L	regulates	gene	0.60
RAB7A	inhibits	gene	0.60
ATG101	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
ATG13	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
ATG5	activates	gene	0.60
BECLIN1	activates	gene	0.60
CANCER	activates	gene	0.60
MICROTUBULES	activates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
NF-ΚB	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
ENDOSOME	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
ROS	activates	gene	0.60
PARKIN	regulates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
PINK1	regulates	gene	0.60
PTEN	regulates	gene	0.60
PI3K	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG9A in their description or question text

No additional research found