protein

OPTINEURIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPTINEURIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1226Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

OPTINEURIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Alzheimer. Connected to 396 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	OPTINEURIN
Chromosome	10p13
Protein Family	Selective autophagy receptors (SQSTM1-like)
Protein Type	Adaptor Protein
Function	The UBAN domain recognizes ubiquitin chains on mitochondria, while the LIR motif recruits autophagosomes.
Molecular Weight	~67 kDa
Amino Acids	577
Pathways	Amyloid, Autophagy, Myelination, Necroptosis, Oxidative Stress
UniProt ID	Q96CV9
GeneCards	OPTINEURIN
Human Protein Atlas	OPTINEURIN
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia
Interactions	ABCD3, ACTB, Actin, Akt, AKT1, AKT1S1
KG Connections	1224 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: OPTINEURIN — AlphaFold Q96CV9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Optineurin

protein · 2027 words

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Pathway Diagram

flowchart TD
    OPTINEURIN(["OPTINEURIN"])
    ULK1(["ULK1"])
    PINK1(["PINK1"])
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ALS["ALS"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    Cardiovascular["Cardiovascular"]
    Parkinson["Parkinson"]
    Fibrosis["Fibrosis"]
    Cancer["Cancer"]
    Tumor["Tumor"]

    OPTINEURIN -->|"recruits"| ULK1
    PINK1 -->|"recruits"| OPTINEURIN
    OPTINEURIN -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    OPTINEURIN -->|"interacts with"| ALS
    OPTINEURIN -->|"interacts with"| Dementia
    OPTINEURIN -->|"interacts with"| Alzheimer
    OPTINEURIN -->|"interacts with"| Frontotemporal_Dementia
    OPTINEURIN -->|"interacts with"| Cardiovascular
    OPTINEURIN -->|"interacts with"| Parkinson
    OPTINEURIN -->|"interacts with"| Fibrosis
    OPTINEURIN -->|"interacts with"| Cancer
    OPTINEURIN -->|"associated with"| Tumor
    OPTINEURIN -->|"associated with"| Parkinson
    OPTINEURIN -->|"associated with"| ALS
    OPTINEURIN -->|"associated with"| Frontotemporal_Dementia

    style OPTINEURIN fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (691)

Target	Relation	Type	Str
MITOPHAGY	mediates	process	0.90
ULK1	associated_with	protein	0.72
Alzheimer	expressed_in	disease	0.65
Ms	protects_against	disease	0.65
Als	causes	disease	0.65
Alzheimer	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Als	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Hypertension	activates	disease	0.65
Senescence	associated_with	disease	0.65
Ms	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Glaucoma	interacts_with	disease	0.65
Ms	activates	disease	0.65
Ftd	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Dementia	causes	disease	0.65
Dementia	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Dementia	interacts_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Infection	inhibits	disease	0.65
Parkinson	activates	disease	0.65
Ms	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Huntington	contributes_to	disease	0.65
Als	interacts_with	disease	0.65
Glaucoma	associated_with	disease	0.65

Incoming (535)

Source	Relation	Type	Str
TBK1	binds	protein	0.90
TBK1	phosphorylates	protein	0.85
PINK1	associated_with	protein	0.72
RB1CC1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
FTLD	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
INFLAMMATION	degrades	gene	0.60
GSK3	associated_with	gene	0.60
ALZHEIMER DISEASE	degrades	gene	0.60
C9ORF72	interacts_with	gene	0.60
DRP1	activates	entity	0.60
OPTN	interacts_with	gene	0.60
DNM1L	activates	entity	0.60
CALCOCO2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
ALZHEIMER	activates	gene	0.60
BCL2L11	interacts_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEURON	expressed_in	gene	0.60
RNA	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
P53	associated_with	gene	0.60
RNA	degrades	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
GSH	regulates	gene	0.60
P53	activates	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
ALZHEIMER	degrades	gene	0.60
PARKINSON	associated_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AUTOPHAGY	degrades	gene	0.60
DDIT3	activates	entity	0.60
PPARG	interacts_with	gene	0.60
DISC1	activates	entity	0.60
ALZHEIMER DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
HUNTINGTON	expressed_in	gene	0.60
SQSTM1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OPTINEURIN in their description or question text

No additional research found