gene

SMCR8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMCR8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

239Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SMCR8 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, implicated in. Associated with AD, ALI, AMI. Connected to 107 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SMCR8
Full Name	SMCR8, SMOX Modifier 1
Aliases	SMCR8 gene
Chromosome	9p21.1
Function	SMCR8 (SMCR8 - SMOX Modifier 1) is a protein coding gene that functions as a positive regulator of autophagy and lysosomal trafficking.
Primary Expression	neurons and glial cells, where it participates in cellular clearance mechanisms critical for neuronal health
Molecular Weight	53 kDa
Amino Acids	479 aa
Exons	12
Pathways	Autophagy, Mtor, Oxidative Stress
UniProt ID	Q8TBX5
NCBI Gene ID	94015
GeneCards	SMCR8
Human Protein Atlas	SMCR8
Associated Diseases	AD, ALI, Als, AMI, amyotrophic lateral sclerosis, degenerative disease
Known Drugs/Compounds	rapamycin
Interactions	ACTB, ALS, AMPK, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND
KG Connections	239 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMCR8 — AlphaFold Q8TBX5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SMCR8 Gene

gene · 1249 words

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Pathway Diagram

graph TD
    SMCR8["SMCR8"]
    SMCR8 -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SMCR8 -->|"interacts"| Dementia["Dementia"]
    SMCR8 -->|"interacts"| Als["Als"]
    SMCR8 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    SMCR8 -->|"interacts"| Ftd["Ftd"]
    SMCR8 -->|"interacts"| Ms["Ms"]
    SMCR8 -->|"interacts"| Inflammation["Inflammation"]
    SMCR8 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    WDR41["WDR41"] -->|"interacts"| SMCR8
    ACTB["ACTB"] -->|"interacts"| SMCR8
    OPTN["OPTN"] -->|"interacts"| SMCR8
    ULK1["ULK1"] -->|"interacts"| SMCR8
    SQSTM1["SQSTM1"] -->|"interacts"| SMCR8
    MAP1LC3["MAP1LC3"] -->|"interacts"| SMCR8
    WIPI2["WIPI2"] -->|"regulates"| SMCR8
    C9ORF72["C9ORF72"] -->|"interacts"| SMCR8
    MTOR["MTOR"] -->|"regulates"| SMCR8
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"regulates"| SMCR8

Outgoing (142)

Target	Relation	Type	Str
ULK1	regulates	entity	0.88
autophagy pathway	participates_in	pathway	0.70
BECN1	regulates	entity	0.70
Dementia	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Ftd	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Als	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Ftd	interacts_with	disease	0.65
Als	regulates	disease	0.65
Dementia	regulates	disease	0.65
Dementia	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
TBK1	activates	gene	0.60
TARDBP	activates	gene	0.60
TFEB	activates	gene	0.60
TAX1BP1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
TAR	activates	gene	0.60
FUS	interacts_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ULK1	expressed_in	gene	0.60
WIPI2	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
TAX1BP1	activates	entity	0.60
TOLLIP	interacts_with	gene	0.60
ALS	activates	disease	0.60
WDR41	activates	gene	0.60
G3BP1	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
ULK1	activates	entity	0.60
UBIQUITIN	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
MTOR	regulates	gene	0.60
FLCN	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
SQSTM1	activates	entity	0.60
oxidative stress response	participates_in	pathway	0.60
TOLLIP	activates	entity	0.60
UBIQUITIN	activates	entity	0.60
C9ORF72	inhibits	gene	0.60

Incoming (97)

Source	Relation	Type	Str
WDR41	interacts_with	protein	0.70
AND	expressed_in	gene	0.60
ALS	inhibits	gene	0.60
AND	inhibits	gene	0.60
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
RNA	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
AND	interacts_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
FTLD	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
ALS	regulates	gene	0.60
AND	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
ALS	activates	entity	0.60
FTD	activates	entity	0.60
RNA	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
MTORC1	activates	gene	0.60
rapamycin	targets	drug	0.60
DNA	activates	gene	0.60
ACTB	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
WIPI2	regulates	gene	0.60
C9ORF72	interacts_with	gene	0.60
FIP200	associated_with	gene	0.60
MTOR	regulates	gene	0.60
FIP200	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
TOLLIP	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
ULK1	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by	0.562	neurodegeneration	How does PIKFYVE inhibition activate unc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMCR8 in their description or question text

No additional research found