disease

Rheumatoid Arthritis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Rheumatoid Arthritis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

539Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AND, ATG16L1, ATG3
Therapeutic Agents	2-Hydroxyestradiol, Beta-Sitosterol, Columbianadin, Curcumin, Shikonin, Tocilizumab
KG Connections	506 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    Rheumatoid_Arthritis["Rheumatoid Arthritis"]
    Als{"Als"}
    Rheumatoid_Arthritis -->|"therapeutic_target"| Als
    Inflammation{"Inflammation"}
    Rheumatoid_Arthritis -->|"therapeutic_target"| Inflammation
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"therapeutic_target"| Rheumatoid_Arthritis
    IL_6(["IL-6"])
    IL_6 -->|"therapeutic_target"| Rheumatoid_Arthritis
    style Rheumatoid_Arthritis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (186)

Target	Relation	Type	Str
Inflammation	inhibits	disease	1.00
Inflammation	activates	disease	1.00
Als	regulates	disease	1.00
Als	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Als	activates	disease	0.95
Nf-Κb	therapeutic_target	pathway	0.90
Neuroinflammation	causes	process	0.85
Inflammation	regulates	disease	0.85
Joint Pain	causes	phenotype	0.85
Als	associated_with	disease	0.85
Diabetes	associated_with	disease	0.85
Inflammation	causes	disease	0.85
Als	inhibits	disease	0.85
Autophagy	associated_with	pathway	0.80
Mtor	activates	pathway	0.80
Immune Response	therapeutic_target	pathway	0.80
Core Fucosylation	associated_with	process	0.75
Alpha-2,6-Sialylation	associated_with	process	0.75
Autoimmune	therapeutic_target	disease	0.75
Inflammatory Bowel Disease	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Psoriasis	inhibits	disease	0.75
Inflammation	associated_with	disease	0.75
Cardiovascular	associated_with	disease	0.75
Autophagy	activates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Tgf-Β	inhibits	pathway	0.70
Lipid Metabolism	activates	pathway	0.70
Immune Response	causes	pathway	0.70
Glycolysis	inhibits	pathway	0.70
Differentiation	activates	pathway	0.70
Immune Response	regulates	pathway	0.70
Immunotherapy	therapeutic_target	pathway	0.70
Inflammatory Bowel Disease	activates	disease	0.65
Psoriasis	activates	disease	0.65
Aging	associated_with	disease	0.65
Lupus	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Asthma	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
Alzheimer	causes	disease	0.65
Infection	associated_with	disease	0.65
Autoimmune	causes	disease	0.65
Mapk	regulates	pathway	0.60
Ferroptosis	regulates	pathway	0.60
Angiogenesis	inhibits	pathway	0.60
Mtor	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60

Incoming (353)

Source	Relation	Type	Str
Autoimmune	associated_with	disease	1.00
INFLAMMATION	activates	gene	1.00
IL-6	therapeutic_target	gene	1.00
CYTOKINES	therapeutic_target	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
INFLAMMATION	inhibits	gene	1.00
TNF	inhibits	gene	1.00
NF-ΚB	therapeutic_target	gene	0.95
INFLAMMATION	causes	gene	0.95
Columbianadin	treats	compound	0.95
TNF inhibitors	treats	drug	0.95
TNF-α	causes	protein	0.95
Osteoporosis	associated_with	disease	0.95
INFLAMMATION	regulates	gene	0.95
IL-17/NF-κB Signaling Pathway	involved_in	pathway	0.90
Shikonin	treats	compound	0.90
Beta-Sitosterol	treats	compound	0.90
Synovial Hyperplasia	contributes_to	phenotype	0.90
TNF-α	drives	protein	0.90
Vav2/Rac-1 Signaling Pathway	involved_in	pathway	0.90
Sensory Nerve Growth	contributes_to	process	0.87
Brain-Spleen Axis	involved_in	mechanism	0.85
TNF	activates	gene	0.85
AKT	inhibits	gene	0.85
2-Hydroxyestradiol	treats	compound	0.85
IL-6	associated_with	protein	0.85
PI3K/AKT	associated_with	pathway	0.85
ERK	inhibits	gene	0.85
INFLAMMATION	associated_with	gene	0.85
Triptolide	treats	drug	0.85
Shikonin	treats	drug	0.85
MTOR	activates	gene	0.85
AUTOPHAGY	associated_with	gene	0.85
Curcumin	treats	drug	0.85
APOPTOSIS	suppresses	process	0.80
IL6	associated_with	protein	0.80
IL-17	biomarker_for	protein	0.80
Tocilizumab	treats	drug	0.80
TNF-α	biomarker_for	protein	0.78
AUTOPHAGY	activates	gene	0.75
AKT	activates	gene	0.75
CYTOKINES	associated_with	gene	0.75
α2,6-sialylation	associated_with	process	0.75
ERK	therapeutic_target	gene	0.75
IL-6	inhibits	gene	0.75
TNF	therapeutic_target	gene	0.75
AGING	associated_with	gene	0.75
Tumor	activates	disease	0.75
CD4	activates	gene	0.75
Tumor	inhibits	disease	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Rheumatoid Arthritis in their description or question text

No additional research found