gene

IRF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

459Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

IRF3 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with AD, ALI, ALS. Connected to 292 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IRF3
Chromosome	19q13.33
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most cell types, including: - Neurons and astrocytes in the brain - Microglia - Pe
Molecular Weight	47 kDa
Amino Acids	424 aa
Exons	10
Pathways	Akt, Autophagy, Innate Immunity, Nf-Κb, Pi3K
NCBI Gene ID	7099
GeneCards	IRF3
Human Protein Atlas	IRF3
Associated Diseases	AD, ALI, Als, Atherosclerosis, cancer
Interactions	Actin, AIM2, AKT, AKT1, ALS, ALZHEIMER
KG Connections	459 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IRF3 Gene

gene · 632 words

→

IRF3 Protein

protein · 1309 words

→

Pathway Diagram

graph TD
    Virus["Viral RNA / cGAS-STING"] -->|"Activates"| TBK1["TBK1 Kinase"]
    TBK1 -->|"Phosphorylates"| IRF3["IRF3 Transcription Factor"]
    IRF3 -->|"Induces"| IFN["Type I Interferons"]
    IRF3 -->|"Activates"| CCL5["CCL5 / RANTES"]
    IRF3 -->|"Activates"| Apoptosis["Apoptosis"]
    IRF3 -->|"Activates"| Autophagy["Autophagy"]
    IRF3 -->|"Activates"| AKT1["AKT1 Survival"]
    IRF3 -->|"Cross-talks"| EGFR["EGFR Pathway"]
    IRF3 -->|"Regulates"| Chromatin["Chromatin Remodeling"]
    IRF3 -.Neuroinflammation.-> AD["Alzheimer's Disease"]
    IRF3 -.Dual role.-> Cancer["Cancer: Suppressor and Promoter"]

Outgoing (304)

Target	Relation	Type	Str
CGAS	activates	gene	1.00
STING	activates	gene	1.00
CGAS-STING	activates	gene	1.00
DNA	activates	gene	1.00
Als	activates	disease	0.95
IFN	activates	protein	0.94
Type I Interferon Expression	activates	process	0.90
Inflammatory Phenotype	associated_with	phenotype	0.90
type I interferon	associated_with	protein	0.90
Infection	activates	disease	0.85
Tumor	activates	disease	0.85
Cancer	activates	disease	0.85
Immune Response	activates	pathway	0.80
Toll-Like Receptor	activates	pathway	0.80
TBK1	activates	gene	0.80
GENES	activates	gene	0.80
Innate Immunity	activates	pathway	0.80
Fibrosis	activates	disease	0.75
Inflammation	inhibits	disease	0.75
Infection	implicated_in	disease	0.75
Inflammation	activates	disease	0.75
SMC	regulates	cell_type	0.72
CGAS	regulates	gene	0.70
Autophagy	regulates	pathway	0.70
CGAS-STING	regulates	gene	0.70
TBK1	inhibits	gene	0.70
Nf-Κb	regulates	pathway	0.70
CGAS	inhibits	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
DNA	inhibits	gene	0.70
CGAS-STING	inhibits	gene	0.70
TNF-Α	inhibits	gene	0.70
NF-kB signaling	participates_in	pathway	0.70
Oxidative Stress	activates	pathway	0.70
MTDNA	inhibits	gene	0.70
Nf-Κb	activates	pathway	0.70
Invasion	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
MTDNA	activates	gene	0.70
CANCER	activates	gene	0.70
Neurodegeneration	activates	disease	0.65
Infection	causes	disease	0.65
Glioblastoma	activates	disease	0.65
Alzheimer	activates	disease	0.65
Depression	activates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Depression	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65

Incoming (155)

Source	Relation	Type	Str
TBK1	activates	gene	1.00
STING1	activates	protein	0.90
ZBP1	interacts_with	protein	0.90
TLR2	inhibits	protein	0.80
INFLAMMATION	activates	gene	0.80
STING	activates	gene	0.80
AUTOPHAGY	regulates	gene	0.70
MAVS	activates	gene	0.70
RAS	activates	gene	0.70
INFLAMMATION	inhibits	gene	0.70
NF-ΚB	activates	gene	0.70
TNF	inhibits	gene	0.70
NF-ΚB	regulates	gene	0.70
YTHDF2 degradation	regulates	phenotype	0.70
MITOCHONDRIAL DNA	activates	gene	0.70
DSDNA	activates	gene	0.70
CYTOKINES	activates	gene	0.70
TBK1	phosphorylates	protein	0.64
GADD45G	regulates	gene	0.60
P62	activates	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
TFAM	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
TAX1BP1	regulates	gene	0.60
P62	regulates	gene	0.60
NBR1	regulates	gene	0.60
TBK1	regulates	gene	0.60
OPTN	regulates	gene	0.60
NDP52	regulates	gene	0.60
STING	regulates	gene	0.60
TRAF6	activates	gene	0.60
JNK	activates	gene	0.60
AKT1	activates	gene	0.60
EGF	activates	gene	0.60
TBK1	interacts_with	gene	0.60
TLR3	activates	gene	0.60
TLR4	activates	gene	0.60
MLKL	activates	gene	0.60
RIPK1	activates	gene	0.60
GENES	activates	gene	0.60
PER	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AND	inhibits	gene	0.60
DEPRESSION	expressed_in	gene	0.60
ALS	activates	gene	0.60
SQSTM1	activates	gene	0.60
MAP3K4	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning IRF3 in their description or question text

No additional research found