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protein 2,027 words KG: OPTINEURIN
Contents

Optineurin

🔬 Protein Info
Gene SymbolOPTINEURIN
Chromosome10p13
Protein FamilySelective autophagy receptors (SQSTM1-like)
Protein TypeAdaptor Protein
FunctionThe UBAN domain recognizes ubiquitin chains on mitochondria, while the LIR motif recruits autophagosomes.
Molecular Weight~67 kDa
Amino Acids577
PathwaysAmyloid, Autophagy, Myelination, Necroptosis, Oxidative Stress
UniProt IDQ96CV9
GeneCardsOPTINEURIN
Human Protein AtlasOPTINEURIN
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia
InteractionsABCD3, ACTB, Actin, Akt, AKT1, AKT1S1
KG Connections1215 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (15)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74Phase-Separated Organelle Targeting
Score: 0.73Stress Granule Phase Separation Modulators
Score: 0.72Autophagosome Maturation Checkpoint Control
Score: 0.71Axonal RNA Transport Reconstitution
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67RNA Granule Nucleation Site Modulation
Score: 0.66The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62VCP-Mediated Autophagy Enhancement
Score: 0.59PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedMitochondrial transfer between neurons and glia
neurodegeneration · completed

See Also (6)

ABCD3 Gene
gene · KG edge: interacts_withACTB Gene
gene · KG edge: interacts_withAKT1 Gene
gene · KG edge: interacts_withAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

DDIT3 activates OPTINEURIN
DISC1 activates OPTINEURIN
PPARG interacts_with OPTINEURIN
DNM1L activates OPTINEURIN
DRP1 activates OPTINEURIN
C9ORF72 interacts_with OPTINEURIN
LC3 interacts_with OPTINEURIN
P62 interacts_with OPTINEURIN
FUS interacts_with OPTINEURIN
UBIQUITIN interacts_with OPTINEURIN

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