Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HUNTINGTON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HUNTINGTON is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 908 entities in the SciDEX knowledge graph.
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| Gene Symbol | HUNTINGTON |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | pazopanib, RAPAMYCIN, roflumilast |
| Interactions | Actin, ADAM10, AGING, AIF, AKT, ALZHEIMER |
| KG Connections | 2446 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HUNTINGTON["HUNTINGTON"] -->|"associated"| LYSOSOME["LYSOSOME"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| SIRT1["SIRT1"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| ALS["ALS"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| Huntington["Huntington"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
ASTROCYTE["ASTROCYTE"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
AMPK["AMPK"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
APP["APP"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
BDNF["BDNF"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
style HUNTINGTON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| Als | implicated_in | disease | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| Neurodegeneration | implicated_in | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Neurodegeneration | implicated_in | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | implicated_in | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 1.00 |
| Huntington | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| HUNTINGTON'S DISEASE | implicated_in | gene | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| HUNTINGTON'S DISEASE | associated_with | gene | 1.00 |
| ALZHEIMER | implicated_in | gene | 1.00 |
| HUNTINGTON'S DISEASE | causes | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| Alzheimer | implicated_in | disease | 1.00 |
| Parkinson | causes | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| Huntington | regulates | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| Parkinson | implicated_in | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | causes | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Huntington | implicated_in | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATIVE DISEASES | implicated_in | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | causes | gene | 1.00 |
| PARKINSON | regulates | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| HUNTINGTON'S DISEASE | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| HUNTINGTON | associated_with | gene | 1.00 |
| PARKINSON | implicated_in | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| HUNTINGTON | activates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| HUNTINGTON | implicated_in | gene | 1.00 |
| HUNTINGTON'S DISEASE | implicated_in | gene | 1.00 |
| ALZHEIMER | implicated_in | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| HUNTINGTON | regulates | gene | 1.00 |
| ALZHEIMER | regulates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| HUNTINGTON'S DISEASE | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| TAU | associated_with | protein | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| AMYLOID | associated_with | protein | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| HUNTINGTON'S DISEASE | causes | gene | 1.00 |
| ALS | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON | causes | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 1.00 |
| NEURODEGENERATION | implicated_in | gene | 1.00 |
| medium spiny neurons | causes_loss_of | cell_type | 1.00 |
| HUNTINGTON | causes | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| ALZHEIMER | causes | gene | 1.00 |
| NEURODEGENERATION | implicated_in | gene | 1.00 |
| ASTROCYTES | associated_with | cell_type | 0.98 |
| ALZHEIMER'S DISEASE | implicated_in | gene | 0.95 |
| AGING | activates | gene | 0.95 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.95 |
| MTOR | activates | gene | 0.95 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity