gene

ATG14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

326Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATG14 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Aging, Als. Connected to 214 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG14
Full Name	Autophagy Related 14
Chromosome	10q26.3
Function	is a crucial autophagy protein that plays a central role in the initiation of autophagosome formation.
Amino Acids	492 aa
Exons	12
Pathways	Apoptosis, Autophagy, Cell Cycle, Epithelial-Mesenchymal Transition, Inflammasome
UniProt ID	Q9Y5P8
NCBI Gene ID	22889
Ensembl ID	ENSG00000131725
OMIM	614113
GeneCards	ATG14
Human Protein Atlas	ATG14
Associated Diseases	ALS, Cancer, dementia, frontotemporal, Infection, Lung Cancer
Interactions	ACTB, AIM2, AMPK, AND, APOPTOSIS, AR
KG Connections	326 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATG14 — AlphaFold Q9Y5P8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG14["ATG14"] -->|"biomarker for"| Aging["Aging"]
    ATG14["ATG14"] -->|"biomarker for"| Als["Als"]
    ATG14["ATG14"] -->|"regulates"| Alzheimer["Alzheimer"]
    ATG14["ATG14"] -->|"interacts"| Als_1["Als"]
    ATG14["ATG14"] -->|"regulates"| Als_2["Als"]
    ATG14["ATG14"] -->|"activates"| Als_3["Als"]
    NRBF2["NRBF2"] -->|"regulates"| ATG14["ATG14"]
    NRBF2_4["NRBF2"] -->|"interacts"| ATG14["ATG14"]
    ACTB["ACTB"] -->|"associated"| ATG14["ATG14"]
    CDC42["CDC42"] -->|"associated"| ATG14["ATG14"]
    style ATG14 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (214)

Target	Relation	Type	Str
ER-Mitochondria Contact Sites	associated_with	organelle	0.95
ER-Mitochondria Contact Site	associated_with	mechanism	0.95
autophagosome formation	involved_in	process	0.93
Autophagy	associated_with	pathway	0.90
Autophagosome Formation	biomarker_for	process	0.85
lipid_droplets	targets	biological_process	0.80
Als	regulates	disease	0.75
Autophagy	regulates	pathway	0.70
MAP1LC3A	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
ATG16L1	associated_with	gene	0.70
Autophagy	activates	pathway	0.70
APOPTOSIS	associated_with	gene	0.70
Apoptosis	associated_with	pathway	0.70
AUTOPHAGY	associated_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Senescence	activates	disease	0.65
Als	activates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Diabetes	regulates	disease	0.65
Infection	activates	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Tumor	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Nafld	regulates	disease	0.65
Ulcerative Colitis	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Lung Cancer	associated_with	disease	0.65
Lung Cancer	activates	disease	0.65
Cancer	regulates	disease	0.65
Fatty Liver	regulates	disease	0.65
Infection	associated_with	disease	0.65
ALS	biomarker_for	disease	0.65
Melanoma	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
ALS	associated_with	disease	0.60
CASP3	associated_with	gene	0.60
Inflammasome	activates	pathway	0.60
CANCER	associated_with	gene	0.60
UBIQUITIN	regulates	gene	0.60

Incoming (112)

Source	Relation	Type	Str
Starvation	activates	process	0.90
STX17	binds	protein	0.90
Starvation	upregulates	phenotype	0.85
YTHDF1	associated_with	protein	0.80
PtdIns(4,5)P2	binds	chemical	0.80
BECN2	binds	protein	0.80
STX18	binds	protein	0.80
AUTOPHAGY	associated_with	gene	0.80
NRBF2	regulates	protein	0.70
NRBF2	interacts_with	protein	0.70
PI3KC3	regulates	gene	0.70
BECN1	activates	gene	0.70
LC3	activates	gene	0.70
BECN1	associated_with	gene	0.70
PIK3C3	regulates	gene	0.70
ACTB	associated_with	gene	0.70
GAPDH	associated_with	gene	0.60
MAP1LC3B	regulates	gene	0.60
MAP3K5	regulates	gene	0.60
UVRAG	regulates	gene	0.60
H2AX	associated_with	gene	0.60
OCLN	regulates	gene	0.60
RAC1	regulates	gene	0.60
TUBULIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
VIMENTIN	regulates	gene	0.60
ASC	activates	gene	0.60
AIM2	activates	gene	0.60
SQSTM1	activates	gene	0.60
VAMP8	activates	gene	0.60
ULK1	activates	gene	0.60
CTSB	activates	gene	0.60
ATP6V0D1	activates	gene	0.60
NLRP3	activates	gene	0.60
IL6	activates	gene	0.60
LAMP1	activates	gene	0.60
PYCARD	activates	gene	0.60
P62	activates	gene	0.60
SNAP29	activates	gene	0.60
MAP1LC3C	associated_with	gene	0.60
TP53	activates	gene	0.60
PIK3C3	activates	gene	0.60
TFEB	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
PPARA	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
VPS4A	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG14 in their description or question text

No additional research found