gene

CD4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

989Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CD4 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 526 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CD4
Chromosome	12p13.31.
Protein Family	Immunoglobulin superfamily
Protein Type	Receptor
Function	Binding to MHC class II molecules on antigen-presenting cells
Molecular Weight	55 kDa
Pathways	Amyloid, Apoptosis, Autophagy, Complement, Differentiation
UniProt ID	P01730
NCBI Gene ID	921
Ensembl ID	ENSG00000149257
GeneCards	CD4
Human Protein Atlas	CD4
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Autoimmune
Known Drugs/Compounds	FINGOLIMOD
Interactions	ACTB, AGING, AKK, AKT, Alpha-Synuclein, ALPHA-SYNUCLEIN
KG Connections	988 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CD4 — AlphaFold P01730 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    CD4["CD4
T-helper cell receptor"]
    
    CD4 -->|"regulates"| Neuroinflammation["Neuroinflammation
Process"]
    CD4 -->|"activates"| MS_activation["Multiple Sclerosis
Activation"]
    CD4 -->|"inhibits protective"| ALS_protection["ALS
Neuroprotection"]
    CD4 -->|"regulates"| PD_pathology["Parkinson's Disease
Pathology"]
    CD4 -->|"biomarker"| ALS_progression["ALS
Disease Progression"]
    CD4 -->|"therapeutic target"| MS_treatment["MS
Therapeutic Intervention"]
    
    Neuroinflammation -->|"promotes"| Neurodegeneration["Neurodegeneration
Process"]
    Neuroinflammation -->|"contributes to"| Dementia_risk["Dementia
Risk Development"]
    
    MS_activation -->|"drives"| Autoimmune_response["Autoimmune
Response"]
    MS_activation -->|"leads to"| Myelin_damage["Myelin
Degradation"]
    
    ALS_protection -->|"loss results in"| Motor_neuron_death["Motor Neuron
Degeneration"]
    
    PD_pathology -->|"accelerates"| Dopaminergic_loss["Dopaminergic
Neuron Loss"]
    
    Autoimmune_response -->|"triggers"| CNS_inflammation["CNS
Inflammation"]
    CNS_inflammation -->|"exacerbates"| Neurodegeneration
    
    CD4 -->|"regulates"| Aging_process["Cellular
Aging Process"]
    Aging_process -->|"increases risk"| Neurodegeneration
    
    MS_treatment -->|"targets"| CD4_modulation["CD4+ T-cell
Modulation"]
    CD4_modulation -->|"reduces"| Neuroinflammation
    
    style CD4 fill:#006494
    style MS_treatment fill:#1b5e20
    style CD4_modulation fill:#1b5e20
    style ALS_protection fill:#1b5e20
    style Neuroinflammation fill:#ef5350
    style MS_activation fill:#ef5350
    style Autoimmune_response fill:#ef5350
    style CNS_inflammation fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style Motor_neuron_death fill:#5d4400
    style Dementia_risk fill:#5d4400

Outgoing (721)

Target	Relation	Type	Str
Inflammation	regulates	disease	1.00
Inflammation	activates	disease	1.00
T CELLS	interacts_with	cell_type	0.95
Als	inhibits	disease	0.95
Brain Inflammation	mediates	process	0.95
Als	regulates	disease	0.95
Neurodegeneration	mediates	process	0.95
Dopaminergic Cell Loss	causes	phenotype	0.90
T cells	associated_with	cell_type	0.90
Parkinson's Disease	contributes_to	disease	0.90
Als	therapeutic_target	disease	0.85
Inflammation	associated_with	disease	0.85
Inflammation	inhibits	disease	0.85
Als	activates	disease	0.85
Dementia	associated_with	disease	0.80
T cells	expressed_in	cell_type	0.80
T cells	regulates	cell_type	0.80
Immune Response	activates	pathway	0.80
Immune Response	regulates	pathway	0.80
Autoimmune	activates	disease	0.75
Infection	activates	disease	0.75
Neuroinflammation	inhibits	disease	0.75
Rheumatoid Arthritis	activates	disease	0.75
Cancer	expressed_in	disease	0.75
Autoimmune	therapeutic_target	disease	0.75
Sepsis	activates	disease	0.75
Ulcerative Colitis	regulates	disease	0.75
Als	causes	disease	0.75
Tumor	inhibits	disease	0.75
Infection	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Multiple Sclerosis	therapeutic_target	disease	0.75
Aging	activates	disease	0.75
Als	expressed_in	disease	0.75
Aging	associated_with	disease	0.75
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Carcinoma	inhibits	disease	0.75
Carcinoma	expressed_in	disease	0.75
Tumor	expressed_in	disease	0.75
Parkinson	activates	disease	0.75
Infection	regulates	disease	0.75
NEUROINFLAMMATION	inhibits	gene	0.70
Pyroptosis	associated_with	pathway	0.70
B cells	associated_with	cell_type	0.70
Differentiation	regulates	pathway	0.70
primary open-angle glaucoma	biomarker_for	disease	0.70
Apoptosis	regulates	pathway	0.70
CD8	inhibits	gene	0.70
FOXP3	activates	gene	0.70

Incoming (268)

Source	Relation	Type	Str
INFLAMMATION	regulates	gene	1.00
INFLAMMATION	activates	gene	1.00
VPU	degrades	protein	0.95
PTPN23	mediates	protein	0.85
CD19	associated_with	gene	0.80
CD8	associated_with	gene	0.80
AKT	activates	gene	0.80
CYTOKINES	expressed_in	gene	0.70
INFLAMMATION	associated_with	gene	0.70
tumor	expressed_in	cell_type	0.70
FOXP3	activates	gene	0.70
GENES	associated_with	gene	0.70
PARKINSON'S DISEASE	expressed_in	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
PARKINSON	activates	gene	0.70
ERK	activates	gene	0.70
FOXP3	regulates	gene	0.70
CYTOKINES	activates	gene	0.70
GLAUCOMA	contributes_to	gene	0.60
IL-17	regulates	gene	0.60
RNA	interacts_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
RNA	associated_with	gene	0.60
TRAF6	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
STAR	expressed_in	gene	0.60
SOCS3	activates	gene	0.60
FOXP3	inhibits	gene	0.60
CD63	inhibits	gene	0.60
CD81	inhibits	gene	0.60
SIRT1	activates	gene	0.60
FAS	inhibits	gene	0.60
STAT3	activates	gene	0.60
GAIN	causes	gene	0.60
STAT3	causes	gene	0.60
IL22	activates	gene	0.60
CD14	associated_with	gene	0.60
CRH	associated_with	gene	0.60
CYBB	associated_with	gene	0.60
CD163	associated_with	gene	0.60
CSF1R	associated_with	gene	0.60
CLU	associated_with	gene	0.60
JUN	expressed_in	gene	0.60
ARC	activates	gene	0.60
FOS	therapeutic_target	gene	0.60
GFAP	associated_with	gene	0.60
ALDH1L1	associated_with	gene	0.60
AKK	regulates	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway	0.772	neurodegeneration	View
Differential Complement Regulator Expression on Synaptic Mem	0.725	synaptic biology	What determines the selectivity of compl
Anti-CD47/SIRPα Checkpoint Therapy to Enhance Phagocytic Cle	0.500	immunomics	Systemic immune profiling in neurodegene
CD44-Mediated Src/PI3K/Akt Signaling Cascade	0.470	neuroinflammation	What molecular mechanisms mediate SPP1-i
Microglial Membrane Camouflage Exploits CD47-SIRPα Checkpoin	0.444	neuroinflammation	How does Alectinib, a kinase inhibitor,

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
The temporal and stimuli-specific effects of LPS and IFNγ on microglial activati [PMID:41695273]	Heiss CN, Naylor AS, Pesämaa I, Meshi A,	Front Aging Neurosci	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD4 in their description or question text

No additional research found

CD4

Understanding Entity Pages

Summary

Wiki Pages (11)

CD4 Gene

CD47-SIRPα Immune Checkpoint Therapy

CD44 Protein

CD44 - Cell Surface Glycoprotein

Innate Immune Reprogramming: NLRP3 + CD47 Checkpoint Blockade

CD4 Protein

CD40 - Cluster of Differentiation 40

CD40 Protein - Cluster of Differentiation 40

CD47 Gene

CD46

CD47 Protein