gene

SMAC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

38Outgoing

37Incoming

0Experiments

0Debates

Summary

SMAC is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, therapeutic target. Associated with Aging, Als, Ataxia. Connected to 51 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SMAC
Full Name	Second Mitochondria-Derived Activator of Caspases
Chromosome	12p12.31
Function	Mitochondrial release: Upon apoptotic stimuli, SMAC is released from mitochondrial intermembrane space
Molecular Weight	29 kDa
Amino Acids	239 aa
Pathways	Apoptosis
UniProt ID	Q9NR28
NCBI Gene ID	56616
Ensembl ID	ENSG00000184047
OMIM	605704
GeneCards	SMAC
Human Protein Atlas	SMAC
Associated Diseases	Glioblastoma
Interactions	Actin, AND, APOPTOSIS, ATM, ATR, AUTOPHAGY
KG Connections	75 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMAC — AlphaFold Q9NR28 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SMAC Gene

gene · 826 words

→

SMAC/DIABLO Protein

protein · 592 words

→

Pathway Diagram

graph TD
    SMAC["SMAC"]
    Als{"Als"}
    SMAC -->|"activates"| Als
    Ms{"Ms"}
    SMAC -->|"interacts with"| Ms
    Aging{"Aging"}
    SMAC -->|"activates"| Aging
    SMAC -->|"inhibits"| Ms
    Tumor{"Tumor"}
    SMAC -->|"activates"| Tumor
    Glioblastoma{"Glioblastoma"}
    SMAC -->|"associated with"| Glioblastoma
    SMAC -->|"regulates"| Ms
    Stroke{"Stroke"}
    SMAC -->|"regulates"| Stroke
    Neurodegeneration{"Neurodegeneration"}
    SMAC -->|"regulates"| Neurodegeneration
    SMAC -->|"activates"| Ms
    Ataxia{"Ataxia"}
    SMAC -->|"activates"| Ataxia
    LC3["LC3"]
    SMAC -->|"activates"| LC3
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| SMAC
    DIABLO["DIABLO"]
    DIABLO -->|"interacts with"| SMAC
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| SMAC
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| SMAC
    HTRA2["HTRA2"]
    HTRA2 -->|"interacts with"| SMAC
    MICROGLIA_ACTIVATION["MICROGLIA ACTIVATION"]
    MICROGLIA_ACTIVATION -->|"activates"| SMAC
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"associated with"| SMAC
    CD8["CD8"]
    CD8 -->|"activates"| SMAC
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| SMAC
    E2F1["E2F1"]
    E2F1 -->|"regulates"| SMAC
    P53["P53"]
    P53 -->|"regulates"| SMAC
    MYC["MYC"]
    MYC -->|"regulates"| SMAC
    style SMAC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
Apoptosis	activates	pathway	0.70
Ms	interacts_with	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	activates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Ms	regulates	disease	0.65
Stroke	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Ms	activates	disease	0.65
Ataxia	activates	disease	0.65
CYLD	activates	gene	0.60
LC3	activates	gene	0.60
AIF	regulates	gene	0.60
ATR	activates	gene	0.60
DNA	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
Autophagy	activates	pathway	0.60
TNF-ALPHA	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
ATM	activates	gene	0.60
Apoptosis	regulates	pathway	0.60
Caspase	activates	protein	0.60
BID	activates	gene	0.60
Actin	activates	protein	0.60
Ubiquitin	activates	protein	0.60
MYC	regulates	gene	0.60
FADD	activates	gene	0.60
TNF	activates	gene	0.60
DIABLO	inhibits	gene	0.60
SMAC/DIABLO	inhibits	protein	0.50
apoptosis	inhibits	process	0.50
CASPASE-8	activates	protein	0.50

Incoming (37)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	0.70
AUTOPHAGY	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
MICROGLIA	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
MITOCHONDRIA	activates	gene	0.60
CD8	activates	gene	0.60
E2F1	regulates	gene	0.60
MYC	regulates	gene	0.60
DIABLO	regulates	gene	0.60
EGF	regulates	gene	0.60
ERK1	regulates	gene	0.60
MDM2	regulates	gene	0.60
RAF1	regulates	gene	0.60
P38	regulates	gene	0.60
DYRK1A	regulates	gene	0.60
AIF	regulates	gene	0.60
JNK	regulates	gene	0.60
TNF	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
P53	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
TNF-ALPHA	inhibits	gene	0.60
AND	activates	gene	0.60
ATM	activates	gene	0.60
ATR	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
DIABLO	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MDM2	activates	gene	0.60
CYLD	activates	gene	0.60
RIPK1	activates	gene	0.60
P21	regulates	gene	0.60
STROKE	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
DIABLO	inhibits	gene	0.50
FADD	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMAC in their description or question text

No additional research found