gene

NR1H3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR1H3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

241Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive gene page for NR1H3 (LXRA), a nuclear receptor regulating cholesterol homeostasis, lipid metabolism, and neuroinflammation in Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	NR1H3
Full Name	Nuclear Receptor Subfamily 1 Group H Member 3
Chromosome	11p11.2
Protein Type	Transcription Factor
Function	is a ligand-activated transcription factor that plays a critical role in regulating cholesterol homeostasis, lipid metabolism, and inflammatory responses<sup>[1]</sup>.
Primary Expression	multiple tissues including the brain, liver, kidney, and adipose tissue<sup>[2]</sup>
Amino Acids	445 aa
Exons	11
Pathways	Autophagy, Chaperone, Cholesterol, ER stress, Er Stress
UniProt ID	[Q9GZN5](https://www.uniprot.org/uniprot/Q9GZN5)
Ensembl ID	ENSG00000125448
GeneCards	NR1H3
Human Protein Atlas	NR1H3
Associated Diseases	Cancer, Carcinoma, Lung Cancer, Melanoma, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ABCD1, ABCD3, ACOX1, Adiponectin, ADIPOQ, AMPK
KG Connections	241 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NR1H3 - Nuclear Receptor Subfamily 1 Group H Member 3

gene · 1646 words

→

Pathway Diagram

flowchart TD
    NR1H3["NR1H3
(LXRalpha)"]
    
    %% Lipid metabolism pathway
    NR1H3 -->|"expressed_in"| CHOL["Cholesterol
Homeostasis"]
    NR1H3 -->|"expressed_in"| LIPID["Lipid
Metabolism"]
    NR1H3 -->|"interacts_with"| SREBF2["SREBF2
(SREBP-2)"]
    NR1H3 -->|"interacts_with"| PPARA["PPARalpha
(Fatty Acid Oxidation)"]
    
    %% Autophagy and cellular clearance
    NR1H3 -->|"interacts_with"| AUTOPHAGY["Autophagy
Pathway"]
    NR1H3 -->|"interacts_with"| BECN1["BECLIN1
(Autophagy Initiation)"]
    NR1H3 -->|"interacts_with"| ULK1["ULK1
(Autophagy Induction)"]
    NR1H3 -->|"interacts_with"| LAMP2["LAMP2
(Lysosomal Function)"]
    
    %% mTOR signaling
    NR1H3 -->|"interacts_with"| MTOR["mTOR
(Growth Regulation)"]
    NR1H3 -->|"interacts_with"| RPTOR["RAPTOR
(mTORC1 Component)"]
    
    %% Oxidative stress and cell death
    NR1H3 -->|"interacts_with"| NFE2L2["NRF2
(Antioxidant Response)"]
    NR1H3 -->|"interacts_with"| TP53["p53
(Tumor Suppressor)"]
    NR1H3 -->|"interacts_with"| MAP3K5["ASK1
(Stress Kinase)"]
    
    %% Phagocytosis and inflammation
    NR1H3 -->|"interacts_with"| PHAGO["Phagocytosis
Pathway"]
    NR1H3 -->|"interacts_with"| C1Q["C1Q
(Complement System)"]
    
    %% Disease outcomes
    AUTOPHAGY -->|"dysfunction"| NEURODEGENERATION["Neurodegeneration
Risk"]
    CHOL -->|"dysregulation"| NEURODEGENERATION
    NFE2L2 -->|"protection"| NEUROPROTECTION["Neuroprotection"]
    
    style NR1H3 fill:#006494
    style NEUROPROTECTION fill:#1b5e20
    style NFE2L2 fill:#1b5e20
    style AUTOPHAGY fill:#1b5e20
    style NEURODEGENERATION fill:#ef5350
    style TP53 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style CHOL fill:#5d4400
    style LIPID fill:#5d4400

Outgoing (139)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NR1H3	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Lipid Metabolism	associated_with	process	0.85
CHOLESTEROL METABOLISM	regulates	entity	0.85
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Hepatitis	interacts_with	disease	0.65
Obesity	activates	disease	0.65
Als	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Insulin Resistance	activates	disease	0.65
Fatty Liver	activates	disease	0.65
Tumor	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
STX17	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
Chaperone	activates	pathway	0.60
CANCER	associated_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
Phagocytosis	interacts_with	pathway	0.60
Tumor Microenvironment	associated_with	pathway	0.60
Stem Cell	associated_with	pathway	0.60
Immunotherapy	associated_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
PPARA	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
Er Stress	activates	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Autophagy	activates	pathway	0.60
KDM6B	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
Oxidative Stress	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Cholesterol	associated_with	pathway	0.60
INSULIN RESISTANCE	activates	gene	0.60
ATG	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60

Incoming (102)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NR1H3	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
GENES	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MTORC1	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MTORC1	activates	gene	0.60
rapamycin	targets	drug	0.60
ACOX1	activates	gene	0.60
SREBF2	interacts_with	gene	0.60
ADIPOQ	activates	gene	0.60
ACOX1	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RNA	expressed_in	gene	0.60
AND	activates	gene	0.60
MAP3K5	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
HTRA2	activates	entity	0.60
KDM6B	activates	entity	0.60
LAMP2	activates	entity	0.60
LC3	activates	entity	0.60
MAP3K5	activates	entity	0.60
MTOR	activates	entity	0.60
NFE2L2	activates	entity	0.60
NOS3	activates	entity	0.60
NFE2L2	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
AND	inhibits	gene	0.60
P53	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NR1H3 in their description or question text

No additional research found