gene

KDM6B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM6B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

219Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

KDM6B is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, expressed in. Associated with ALS, Als, Hepatitis. Connected to 96 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KDM6B
Full Name	Lysine Demethylase 6B
Aliases	JMJD3
Chromosome	17p13.1
Function	encodes a Jumonji C (JmjC) domain-containing histone demethylase that specifically removes di- and trimethyl marks from histone H3 lysine 27 (H3K27me2/3).
Pathways	NF-κB
UniProt ID	[O15054](https://www.uniprot.org/uniprot/O15054)
Ensembl ID	ENSG00000132510
GeneCards	KDM6B
Human Protein Atlas	KDM6B
Neuronal differentiation	KDM6B removes H3K27me3 from neurogenic gene promoters during the transition from neural stem cells to postmitotic neurons, activating expression of NEUROD1, TBR1, and other neuronal identity genes
Macrophage polarization	KDM6B drives M1 (pro-inflammatory) macrophage/microglial polarization by activating inflammatory gene programs
Aging epigenome	KDM6B expression increases with aging, contributing to the progressive loss of H3K27me3 that characterizes the aging epigenome and potentially derepressing deleterious gene programs
Neuroinflammatory amplification	KDM6B removes H3K27me3 from pro-inflammatory gene promoters (TNF, IL1B, IL6, complement components), converting microglia to a chronic inflammatory state that damages neurons
[Tau](/proteins/tau) pathology	KDM6B activates kinase genes (CDK5, GSK3B) that hyperphosphorylate tau, promoting neurofibrillary tangle formation
Associated Diseases	NAFLD, NASH
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, Adiponectin, ADIPOQ, AMPK, AND, ATG
SciDEX Hypotheses	Microglial priming is primarily epigenetic, with m
KG Connections	219 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KDM6B (JMJD3)

gene · 1050 words

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Pathway Diagram

graph TD
    KDM6B["KDM6B"] -->|"activates"| Als["Als"]
    KDM6B["KDM6B"] -->|"interacts"| Tumor["Tumor"]
    KDM6B["KDM6B"] -->|"interacts"| Hepatitis["Hepatitis"]
    KDM6B["KDM6B"] -->|"activates"| ALS["ALS"]
    KDM6B["KDM6B"] -->|"activates"| LC3["LC3"]
    KDM6B["KDM6B"] -->|"activates"| ATG7["ATG7"]
    FGF21["FGF21"] -->|"activates"| KDM6B["KDM6B"]
    ULK1["ULK1"] -->|"activates"| KDM6B["KDM6B"]
    PPARA["PPARA"] -->|"interacts"| KDM6B["KDM6B"]
    ULK1_1["ULK1"] -->|"interacts"| KDM6B["KDM6B"]
    style KDM6B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (142)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Als	activates	disease	0.65
Tumor	interacts_with	disease	0.65
NEURONS	treats	cell_type	0.65
Hepatitis	interacts_with	disease	0.65
GLUTAMATE	regulates	phenotype	0.65
NEURONS	causes	cell_type	0.65
ALS	activates	disease	0.65
LAMP2	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
ATG7	activates	gene	0.60
FOXO1	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
TFEB	activates	gene	0.60
ULK1	activates	gene	0.60
FGF21	activates	gene	0.60
PPARA	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
NFE2L2	activates	entity	0.60
MTOR	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
MTOR	activates	entity	0.60
NOS3	activates	entity	0.60
NR1H3	activates	entity	0.60
P62	activates	entity	0.60
PLIN2	activates	entity	0.60
PLIN3	activates	entity	0.60
PPARA	activates	entity	0.60
PRKAA2	activates	entity	0.60
RPTOR	activates	entity	0.60
SIRT1	activates	entity	0.60
SIRT3	activates	entity	0.60
SQSTM1	activates	entity	0.60
SREBF1	activates	entity	0.60
SREBF2	activates	entity	0.60
STING1	activates	entity	0.60
MAP3K5	activates	entity	0.60

Incoming (77)

Source	Relation	Type	Str
TAU	interacts_with	protein	0.65
ULK1	activates	gene	0.60
VGLUT2	expressed_in	gene	0.60
ADIPOQ	activates	gene	0.60
AND	activates	gene	0.60
AMPK	activates	entity	0.60
FGF21	activates	gene	0.60
FOXO1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
BECN1	activates	entity	0.60
C1Q	activates	entity	0.60
FOXO1	activates	entity	0.60
GLP1R	activates	entity	0.60
GRK2	activates	entity	0.60
HTRA2	activates	entity	0.60
VGLUT1	activates	gene	0.60
TAU	activates	gene	0.60
GENES	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MTORC1	interacts_with	gene	0.60
ACOX1	activates	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
rapamycin	targets	drug	0.60
SLC17A7	activates	gene	0.60
TFEB	activates	gene	0.60
ATG7	activates	gene	0.60
LAMP2	interacts_with	gene	0.60
LC3	activates	gene	0.60
PLIN3	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
ATGL	activates	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KDM6B in their description or question text

No additional research found