gene

NLRC4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRC4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

212Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NLRC4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, protects against. Associated with Als, Cancer, Colorectal Cancer. Connected to 96 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NLRC4
Protein Type	Receptor
Function	encodes a critical pattern recognition receptor that forms the NLRC4 inflammasome, a multiprotein complex essential for innate immunity and inflammatory responses.
Primary Expression	microglia - Minimal expression in astrocytes under normal conditions - Induction in infiltrating immune
Molecular Weight	186 kDa
Pathways	NF-κB, MAPK pathway
Ensembl ID	ENSG00000102948
GeneCards	NLRC4
Human Protein Atlas	NLRC4
Pattern recognition	LRR domain detects bacterial components
Oligomerization	Activated NLRC4 recruits ASC (PYCARD) via PYD interactions
Caspase-1 activation	NLRC4 CARD domain directly interacts with caspase-1
Pyroptosis	Activated caspase-1 cleaves gasdermin D, causing pyroptotic cell death
Cytokine maturation	Caspase-1 processes pro-IL-1β and pro-IL-18 into active forms
Cross-talk with NLRP3	potential co-activation in some contexts
Associated Diseases	ALS, Cancer, Cardiovascular, Infection, Inflammation, Ms
Interactions	AIM2, ALZHEIMER, AMPK, AMYLOID, AND, APOPTOSIS
KG Connections	212 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NLRC4 Gene

gene · 885 words

→

NLRC4 Protein

protein · 1149 words

→

Pathway Diagram

graph TD
    NLRC4["NLRC4"]
    Ms{"Ms"}
    NLRC4 -->|"associated with"| Ms
    Tumor{"Tumor"}
    NLRC4 -->|"associated with"| Tumor
    NLRC4 -->|"activates"| Ms
    Inflammation{"Inflammation"}
    NLRC4 -->|"activates"| Inflammation
    ASC["ASC"]
    NLRC4 -->|"associated with"| ASC
    NLRP3["NLRP3"]
    NLRC4 -->|"associated with"| NLRP3
    AIM2["AIM2"]
    NLRC4 -->|"associated with"| AIM2
    TNF["TNF"]
    NLRC4 -->|"associated with"| TNF
    MARCH7["MARCH7"]
    NLRC4 -->|"associated with"| MARCH7
    PYCARD["PYCARD"]
    NLRC4 -->|"associated with"| PYCARD
    LAMP1["LAMP1"]
    NLRC4 -->|"associated with"| LAMP1
    Inflammasome(["Inflammasome"])
    NLRC4 -->|"associated with"| Inflammasome
    IL1B["IL1B"]
    IL1B -->|"associated with"| NLRC4
    CASP1["CASP1"]
    CASP1 -->|"associated with"| NLRC4
    ATG5["ATG5"]
    ATG5 -->|"associated with"| NLRC4
    IL18["IL18"]
    IL18 -->|"associated with"| NLRC4
    TNF -->|"associated with"| NLRC4
    MARCH7 -->|"associated with"| NLRC4
    NLRP3 -->|"associated with"| NLRC4
    AIM2 -->|"associated with"| NLRC4
    ASC -->|"associated with"| NLRC4
    ATP["ATP"]
    ATP -->|"associated with"| NLRC4
    AND["AND"]
    AND -->|"associated with"| NLRC4
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| NLRC4
    style NLRC4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (128)

Target	Relation	Type	Str
pyroptosis	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
NF-kB signaling	participates_in	pathway	0.70
Inflammasome	activates	pathway	0.70
Autophagy	associated_with	pathway	0.70
Inflammation	activates	disease	0.65
Ms	associated_with	disease	0.65
Pyroptosis	activates	disease	0.65
Tumor	associated_with	disease	0.65
Ms	activates	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Als	activates	disease	0.65
Melanoma	activates	disease	0.65
Als	inhibits	disease	0.65
Inflammation	causes	disease	0.65
Cardiovascular	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Colorectal Cancer	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Ulcerative Colitis	causes	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
Neutrophil	inhibits	cell_type	0.60
Caspase	inhibits	protein	0.60
NEURODEGENERATION	associated_with	gene	0.60
PYCARD	interacts_with	gene	0.60
Cholesterol	associated_with	pathway	0.60
Immunotherapy	associated_with	pathway	0.60
Ferroptosis	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
Pyroptosis	associated_with	pathway	0.60
IL-1	inhibits	gene	0.60
UCP2	inhibits	gene	0.60
TNF	interacts_with	gene	0.60
PYCARD	activates	gene	0.60
TNF	activates	gene	0.60
NFKB	associated_with	gene	0.60
macrophages	expressed_in	cell_type	0.60
USP5	interacts_with	gene	0.60
USP22	activates	gene	0.60
Nlrp3 Inflammasome	activates	pathway	0.60

Incoming (84)

Source	Relation	Type	Str
AIM2	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
ATP	associated_with	gene	0.60
PRKACA	associated_with	gene	0.60
NAIP	interacts_with	gene	0.60
NFKB	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
ROS	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
Β-HYDROXYBUTYRATE	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
APOPTOSIS	protects_against	gene	0.60
PYROPTOSIS	protects_against	gene	0.60
P53	contributes_to	gene	0.60
INFLAMMATION	causes	gene	0.60
CANCER	expressed_in	gene	0.60
NFKB	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
ATP	activates	gene	0.60
NLR	activates	gene	0.60
LAMP1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
NEK7	associated_with	gene	0.60
NLRP1	associated_with	gene	0.60
CARD8	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
P38	activates	gene	0.60
NAIP	activates	gene	0.60
NLRP3	activates	gene	0.60
AND	associated_with	gene	0.60
AND	activates	gene	0.60
IL-1	associated_with	gene	0.60
NLR	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
NF-ΚB	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
NLRP3	associated_with	gene	0.60
NAIP	associated_with	gene	0.60
TNF	associated_with	gene	0.60
MARCH7	associated_with	gene	0.60
HTRA2	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GBM	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NLRC4 in their description or question text

No additional research found