gene

AIM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AIM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

407Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AIM2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Aging, Als, Atherosclerosis. Connected to 189 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AIM2
Protein Family	AIM2-like receptor (ALR)
Function	AIM2 functions as a cytosolic DNA sensor forming the AIM2 inflammasome.
Subcellular Localization	Cytoplasm
Molecular Weight	39 kDa
Amino Acids	200 aa
Pathways	Apoptosis, Autophagy, Cholesterol, Ferroptosis, Immune Response
UniProt ID	Q9WZE6
GeneCards	AIM2
Human Protein Atlas	AIM2
Associated Diseases	Als, Atherosclerosis, Cancer, Dementia, Infection
Interactions	ACTB, Actin, ALZHEIMER, AMPK, AND, APOPTOSIS
KG Connections	407 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: AIM2 — AlphaFold Q9WZE6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AIM2["AIM2"] -->|"associated"| Ms["Ms"]
    AIM2["AIM2"] -->|"associated"| Tumor["Tumor"]
    AIM2["AIM2"] -->|"regulates"| Als["Als"]
    AIM2["AIM2"] -->|"regulates"| Ms_1["Ms"]
    AIM2["AIM2"] -->|"regulates"| Inflammation["Inflammation"]
    AIM2["AIM2"] -->|"associated"| Dementia["Dementia"]
    IL1B["IL1B"] -->|"associated"| AIM2["AIM2"]
    CASP1["CASP1"] -->|"associated"| AIM2["AIM2"]
    ATG5["ATG5"] -->|"associated"| AIM2["AIM2"]
    NLRC4["NLRC4"] -->|"associated"| AIM2["AIM2"]
    style AIM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (291)

Target	Relation	Type	Str
Inflammasome	activates	pathway	1.00
Inflammation	activates	disease	1.00
PANoptosome	component_of	structure	0.95
INFLAMMATION	activates	gene	0.90
pyroptosis	participates_in	pathway	0.80
Melanoma	activates	disease	0.75
Tumor	associated_with	disease	0.75
Neuroinflammation	promotes	process	0.75
Bacterial Infection	activates	disease	0.75
Infection	activates	disease	0.75
Inflammation	associated_with	disease	0.75
Ferroptosis	associated_with	pathway	0.70
Autophagy	inhibits	pathway	0.70
Oxidative Stress	associated_with	pathway	0.70
Autophagy	associated_with	pathway	0.70
AUTOPHAGY	associated_with	gene	0.70
DNA	activates	gene	0.70
MITOCHONDRIAL DNA	activates	gene	0.70
pyroptosis	activates	process	0.70
NF-kB signaling	participates_in	pathway	0.70
Pyroptosis	associated_with	pathway	0.70
NLRP3	associated_with	gene	0.70
TNF	associated_with	gene	0.70
NLRC4	associated_with	gene	0.70
PYCARD	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
CASP1	associated_with	gene	0.70
IL1B	associated_with	gene	0.70
Ms	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Autoimmune	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Melanoma	interacts_with	disease	0.65
Aging	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Als	regulates	disease	0.65
Senescence	contributes_to	disease	0.65
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Dementia	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Lymphoma	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65

Incoming (116)

Source	Relation	Type	Str
h-var-a0933e666d	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
h-var-6957745fea	targets_gene	hypothesis	0.90
ZBP1	interacts_with	protein	0.85
PYROPTOSIS	associated_with	gene	0.70
ASC	associated_with	gene	0.70
FERROPTOSIS	associated_with	gene	0.70
ATG5	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
TNF	associated_with	gene	0.60
MARCH7	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
PYROPTOSIS	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60
INFLAMMATION	associated_with	gene	0.60
TNF-Α	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
CANCER	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
EXERCISE	inhibits	gene	0.60
Β-HYDROXYBUTYRATE	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
GASDERMIN	regulates	gene	0.60
IL1B	associated_with	gene	0.60
DNA	activates	gene	0.60
CASP1	associated_with	gene	0.60
HDAC6	regulates	gene	0.60
IFI16	associated_with	gene	0.60
CARD8	associated_with	gene	0.60
NLRP1	associated_with	gene	0.60
PYCARD	expressed_in	gene	0.60
NAIP	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
NLRP1	expressed_in	gene	0.60
NLRP2	expressed_in	gene	0.60
ASC	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
GSDMD	activates	gene	0.60
SQSTM1	activates	gene	0.60
ASC	activates	gene	0.60
P62	activates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.824	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.805	neurodegeneration	What are the mechanisms by which gut mic
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.803	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AIM2 in their description or question text

No additional research found