gene

GBM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1358Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GBM is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with AD, ALI, ALS. Connected to 637 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GBM
Full Name	Glioma-Associated Oncogene Homolog
Chromosome	3p25.1
Protein Family	C2H2-type zinc finger transcription factors
Exons	14
Pathways	Amyloid, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P08151
NCBI Gene ID	2735
Ensembl ID	ENSG00000087495
GeneCards	GBM
Human Protein Atlas	GBM
Chromosomal location	3p25.1
Exon count	14 exons
Alternative splicing	Produces full-length activator (GLI3A) and truncated repressor (GLI3R)
Promoter architecture	Contains GLI-binding sites that enable autoregulation
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	quercetin, SSRI
Interactions	Actin, AIM2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	1358 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GBM — AlphaFold P08151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GLI Gene Family

gene · 2171 words

→

GBM Protein — Glioblastoma Multiforme

protein · 747 words

→

Pathway Diagram

flowchart TD
    GBM(["GBM"])
    Glioblastoma["Glioblastoma"]
    Tumor["Tumor"]
    GLIOBLASTOMA(["GLIOBLASTOMA"])
    Cancer["Cancer"]
    Als["Als"]
    CANCER(["CANCER"])
    GENES(["GENES"])

    GBM -->|"associated with"| Glioblastoma
    GBM -->|"activates"| Tumor
    GBM -->|"therapeutic target"| Glioblastoma
    GBM -->|"associated with"| Tumor
    GBM -->|"associated with"| GLIOBLASTOMA
    GBM -->|"therapeutic target"| GLIOBLASTOMA
    GBM -->|"activates"| Cancer
    GBM -->|"associated with"| Cancer
    GBM -->|"therapeutic target"| Tumor
    GBM -->|"therapeutic target"| Cancer
    GBM -->|"regulates"| Als
    GBM -->|"activates"| Glioblastoma
    GBM -->|"activates"| CANCER
    GBM -->|"activates"| GLIOBLASTOMA
    GBM -->|"associated with"| GENES

    style GBM fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (926)

Target	Relation	Type	Str
Tumor	activates	disease	1.00
Glioblastoma	therapeutic_target	disease	1.00
Glioblastoma	associated_with	disease	1.00
Tumor	associated_with	disease	1.00
GLIOBLASTOMA	associated_with	gene	1.00
GLIOBLASTOMA	therapeutic_target	gene	1.00
Als	regulates	disease	0.95
Tumor	therapeutic_target	disease	0.95
Cancer	associated_with	disease	0.95
Glioblastoma	activates	disease	0.95
Cancer	activates	disease	0.95
Cancer	therapeutic_target	disease	0.95
glioblastoma	treats	disease	0.90
T cells	expressed_in	cell_type	0.90
glioblastoma	targets	disease	0.90
blood-brain barrier	participates_in	pathway	0.90
glioblastoma	biomarker_for	disease	0.90
glioblastoma	associated_with	disease	0.90
blood-brain barrier	expressed_in	brain_region	0.90
neural stem cells	regulates	cell_type	0.90
glioblastoma	regulates	disease	0.90
oxidative stress response	participates_in	pathway	0.90
stem cells	expressed_in	cell_type	0.90
GENES	associated_with	gene	0.90
GLIOBLASTOMA	activates	gene	0.90
CANCER	activates	gene	0.90
CANCER	associated_with	gene	0.90
Glioblastoma	regulates	disease	0.85
Glioma	activates	disease	0.85
Glioma	therapeutic_target	disease	0.85
Glioblastoma	expressed_in	disease	0.85
Aging	therapeutic_target	disease	0.85
Als	activates	disease	0.85
neural stem cells	activates	cell_type	0.80
MS4A6A	activates	gene	0.80
unfolded protein response	participates_in	pathway	0.80
glioblastoma	interacts_with	disease	0.80
macrophages	inhibits	cell_type	0.80
PI3K-AKT-mTOR signaling	participates_in	pathway	0.80
lipid metabolism	participates_in	pathway	0.80
immunosuppression	associated_with	pathway	0.80
neural stem cells	associated_with	cell_type	0.80
microglia	inhibits	cell_type	0.80
GENES	activates	gene	0.80
Blood-Brain Barrier	therapeutic_target	pathway	0.80
AKT	activates	gene	0.80
Invasion	associated_with	pathway	0.80
CANCER	therapeutic_target	gene	0.80
GLIOBLASTOMA	expressed_in	gene	0.80
Tumor	biomarker_for	disease	0.75

Incoming (432)

Source	Relation	Type	Str
EGFR	activates	gene	0.90
PI3K	activates	gene	0.80
Wnt	associated_with	pathway	0.70
PI3K/AKT/MTOR	regulates	pathway	0.70
PI3K	therapeutic_target	gene	0.70
TGF-β	associated_with	pathway	0.70
EGFR	associated_with	gene	0.70
ERK	activates	gene	0.70
DNA	therapeutic_target	gene	0.70
STAT3	therapeutic_target	gene	0.70
PTEN	activates	gene	0.70
TP53	associated_with	gene	0.70
CDKN2A	associated_with	gene	0.70
FN1	regulates	gene	0.70
PTEN	associated_with	gene	0.70
SORLA	expressed_in	gene	0.60
CPLX3	inhibits	gene	0.60
ASTROCYTE	contributes_to	gene	0.60
APOPTOSIS	inhibits	gene	0.60
TNF	associated_with	gene	0.60
CAV1	biomarker_for	gene	0.60
CPLX3	activates	gene	0.60
CD68	biomarker_for	gene	0.60
CD44	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
CD8	expressed_in	gene	0.60
ANXA1	implicated_in	gene	0.60
C3	associated_with	gene	0.60
TMEM119	expressed_in	gene	0.60
C3	expressed_in	gene	0.60
ASTROCYTES	associated_with	gene	0.60
FLOT1	activates	gene	0.60
GAP43	interacts_with	gene	0.60
ANXA1	causes	gene	0.60
CLDN3	activates	gene	0.60
AIM2	activates	gene	0.60
CXCR4	activates	gene	0.60
APC	activates	gene	0.60
ASCL1	regulates	gene	0.60
OMA1	activates	gene	0.60
GENES	regulates	gene	0.60
AKT	disrupts	gene	0.60
CRY	activates	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
ERK	associated_with	gene	0.60
MICROGLIA	inhibits	gene	0.60
CANCER	regulates	gene	0.60
POSTN	inhibits	gene	0.60
MICROGLIA	associated_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GBM in their description or question text

No additional research found