gene

NOS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

381Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NOS3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, associated with. Associated with Hepatitis, Ischemia, Ms. Connected to 122 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOS3
Full Name	Endothelial Nitric Oxide Synthase (NOS3)
Aliases	Nitric Oxide Synthase 3
Chromosome	7q36
Protein Type	Protein
Function	This is the basis for the therapeutic use of nitrates in cardiovascular disease [@katusic2009].
Primary Expression	vascular endothelial cells where it catalyzes the production of nitric oxide (NO) from L-arginine
Amino Acids	490 aa
Pathways	Mapk, autophagy pathway, complement cascade, phagocytosis
UniProt ID	Search UniProt
GeneCards	NOS3
Human Protein Atlas	NOS3
Associated Diseases	ALS, Alzheimer, Cancer, podocyte foot process effacement
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, ADAMTS1, Adiponectin, ADIPOQ, AMPK, ATG
KG Connections	381 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NOS3 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Endothelial Nitric Oxide Synthase (NOS3)

protein · 1631 words

→

NOS3 — Nitric Oxide Synthase 3

gene · 603 words

→

Pathway Diagram

flowchart TD
    NOS3["NOS3
(Endothelial NOS)"]
    NO["Nitric Oxide
Production"]
    SIRT1["SIRT1
(Sirtuin 1)"]
    NFE2L2["NFE2L2
(Nrf2)"]
    MTOR["MTOR
(mTOR Complex)"]
    BECN1["BECN1
(Beclin-1)"]
    FOXO1["FOXO1
(FoxO1)"]
    MAP3K5["MAP3K5
(ASK1)"]
    STING1["STING1
(STING)"]
    
    Stroke["Stroke
Protection"]
    Ischemia["Ischemic
Injury"]
    MS["Multiple
Sclerosis"]
    Autophagy["Autophagy
Regulation"]
    Oxidative["Oxidative
Stress"]
    Inflammation["Neuroinflammation"]
    Apoptosis["Cell Death
Pathways"]
    Neuroprotection["Neuroprotection"]

    NOS3 -->|"produces"| NO
    NO -->|"activates"| SIRT1
    NO -->|"activates"| NFE2L2
    SIRT1 -->|"enhances"| NFE2L2
    NFE2L2 -->|"reduces"| Oxidative
    
    NOS3 -->|"inhibits"| MTOR
    MTOR -->|"inhibits"| BECN1
    BECN1 -->|"promotes"| Autophagy
    SIRT1 -->|"activates"| FOXO1
    FOXO1 -->|"promotes"| Autophagy
    
    NOS3 -->|"inhibits"| MAP3K5
    MAP3K5 -->|"promotes"| Apoptosis
    NOS3 -->|"modulates"| STING1
    STING1 -->|"promotes"| Inflammation
    
    NO -->|"protects_against"| Stroke
    NO -->|"reduces"| Ischemia
    NOS3 -->|"therapeutic_for"| MS
    Autophagy -->|"promotes"| Neuroprotection
    NFE2L2 -->|"promotes"| Neuroprotection

    style NOS3 fill:#006494
    style SIRT1 fill:#1b5e20
    style NFE2L2 fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style FOXO1 fill:#4a1a6b
    style MAP3K5 fill:#ef5350
    style STING1 fill:#ef5350
    style Stroke fill:#5d4400
    style Ischemia fill:#ef5350
    style MS fill:#ef5350
    style Neuroprotection fill:#1b5e20
    style Oxidative fill:#ef5350
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350

Outgoing (204)

Target	Relation	Type	Str
Idiopathic Nephrotic Syndrome	biomarker_for	disease	0.85
podocyte foot process effacement	associated_with	phenotype	0.75
nitric oxide	regulates	biomarker	0.70
MAPK signaling	participates_in	pathway	0.70
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	protects_against	disease	0.65
Cancer	protects_against	disease	0.65
Aging	protects_against	disease	0.65
Stroke	therapeutic_target	disease	0.65
ALS	protects_against	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Autophagy	interacts_with	pathway	0.60
TLR4	regulates	gene	0.60
TNF	regulates	gene	0.60
Phagocytosis	interacts_with	pathway	0.60
SIRT1	activates	entity	0.60
SIRT3	activates	entity	0.60
SQSTM1	activates	entity	0.60
SREBF1	activates	entity	0.60
SREBF2	activates	entity	0.60
STING1	activates	entity	0.60
STX17	activates	entity	0.60
STX17	interacts_with	gene	0.60
Rb	therapeutic_target	protein	0.60
PTGS2	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
phagocytosis	activates	process	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
RAS	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
INS	associated_with	gene	0.60
Mtor	interacts_with	pathway	0.60
NR1H3	activates	entity	0.60
P62	activates	entity	0.60
PLIN2	activates	entity	0.60
PLIN3	activates	entity	0.60
PPARA	activates	entity	0.60

Incoming (177)

Source	Relation	Type	Str
Paeoniflorin	upregulates	compound	0.88
Idiopathic Nephrotic Syndrome sera	upregulates	compound	0.75
vascular shear stress	activates	process	0.70
LC3	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
GLP1R	activates	entity	0.60
IL6	associated_with	gene	0.60
ESR2	associated_with	gene	0.60
NOS2	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
AKT1	regulates	gene	0.60
ATG	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
CXCL8	regulates	gene	0.60
IL10	regulates	gene	0.60
IL4	regulates	gene	0.60
IL6	regulates	gene	0.60
ITGAM	regulates	gene	0.60
ACOX1	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
GAA	associated_with	gene	0.60
ADAMTS1	activates	gene	0.60
CAV1	activates	gene	0.60
ESM1	activates	gene	0.60
HPSE	activates	gene	0.60
ICAM1	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
ADAMTS1	interacts_with	gene	0.60
HPSE	interacts_with	gene	0.60
ICAM1	interacts_with	gene	0.60
ESM1	associated_with	gene	0.60
HPSE	associated_with	gene	0.60
ICAM1	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
MTORC1	interacts_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
HIF	associated_with	gene	0.60
ACOX1	activates	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
ACHE	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

endocrinology | 2026-04-13 | 2 hypotheses Top: 0.653

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Despite FDA warnings and a 315% increased erythrocytosis risk with TRT, the asso

closed · Rounds: 4 · Score: 0.83 · 2026-04-14

Related Research

Hypotheses and analyses mentioning NOS3 in their description or question text

No additional research found