gene

NOS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

382Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NOS3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, associated with. Associated with Hepatitis, Ischemia, Ms. Connected to 122 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOS3
Full Name	Endothelial Nitric Oxide Synthase (NOS3)
Aliases	Nitric Oxide Synthase 3
Chromosome	7q36
Protein Type	Protein
Function	This is the basis for the therapeutic use of nitrates in cardiovascular disease [@katusic2009].
Primary Expression	vascular endothelial cells where it catalyzes the production of nitric oxide (NO) from L-arginine
Amino Acids	490 aa
Pathways	Mapk, autophagy pathway, complement cascade, phagocytosis
UniProt ID	Search UniProt
GeneCards	NOS3
Human Protein Atlas	NOS3
Associated Diseases	ALS, Alzheimer, Cancer, podocyte foot process effacement
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, ADAMTS1, Adiponectin, ADIPOQ, AMPK, AND
KG Connections	382 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NOS3 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Endothelial Nitric Oxide Synthase (NOS3)

protein · 1631 words

→

NOS3 — Nitric Oxide Synthase 3

gene · 603 words

→

Pathway Diagram

flowchart TD
    NOS3["NOS3
(Endothelial NOS)"]
    NO["Nitric Oxide
Production"]
    SIRT1["SIRT1
(Sirtuin 1)"]
    NFE2L2["NFE2L2
(Nrf2)"]
    MTOR["MTOR
(mTOR Complex)"]
    BECN1["BECN1
(Beclin-1)"]
    FOXO1["FOXO1
(FoxO1)"]
    MAP3K5["MAP3K5
(ASK1)"]
    STING1["STING1
(STING)"]
    
    Stroke["Stroke
Protection"]
    Ischemia["Ischemic
Injury"]
    MS["Multiple
Sclerosis"]
    Autophagy["Autophagy
Regulation"]
    Oxidative["Oxidative
Stress"]
    Inflammation["Neuroinflammation"]
    Apoptosis["Cell Death
Pathways"]
    Neuroprotection["Neuroprotection"]

    NOS3 -->|"produces"| NO
    NO -->|"activates"| SIRT1
    NO -->|"activates"| NFE2L2
    SIRT1 -->|"enhances"| NFE2L2
    NFE2L2 -->|"reduces"| Oxidative
    
    NOS3 -->|"inhibits"| MTOR
    MTOR -->|"inhibits"| BECN1
    BECN1 -->|"promotes"| Autophagy
    SIRT1 -->|"activates"| FOXO1
    FOXO1 -->|"promotes"| Autophagy
    
    NOS3 -->|"inhibits"| MAP3K5
    MAP3K5 -->|"promotes"| Apoptosis
    NOS3 -->|"modulates"| STING1
    STING1 -->|"promotes"| Inflammation
    
    NO -->|"protects_against"| Stroke
    NO -->|"reduces"| Ischemia
    NOS3 -->|"therapeutic_for"| MS
    Autophagy -->|"promotes"| Neuroprotection
    NFE2L2 -->|"promotes"| Neuroprotection

    style NOS3 fill:#006494
    style SIRT1 fill:#1b5e20
    style NFE2L2 fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style FOXO1 fill:#4a1a6b
    style MAP3K5 fill:#ef5350
    style STING1 fill:#ef5350
    style Stroke fill:#5d4400
    style Ischemia fill:#ef5350
    style MS fill:#ef5350
    style Neuroprotection fill:#1b5e20
    style Oxidative fill:#ef5350
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350

Outgoing (206)

Target	Relation	Type	Str
Idiopathic Nephrotic Syndrome	biomarker_for	disease	0.85
podocyte foot process effacement	associated_with	phenotype	0.75
MAPK signaling	participates_in	pathway	0.70
Stroke	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	protects_against	disease	0.65
Cancer	protects_against	disease	0.65
Aging	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
GLP1R	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
TGFB1	therapeutic_target	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
PTGS2	associated_with	gene	0.60
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
GAA	therapeutic_target	gene	0.60
ULK1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60

Incoming (176)

Source	Relation	Type	Str
Paeoniflorin	upregulates	compound	0.88
Idiopathic Nephrotic Syndrome sera	upregulates	compound	0.75
C1Q	interacts_with	gene	0.60
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
RELA	therapeutic_target	gene	0.60
BECN1	activates	entity	0.60
C1Q	activates	entity	0.60
FOXO1	activates	entity	0.60
GLP1R	activates	entity	0.60
GRK2	activates	entity	0.60
HTRA2	activates	entity	0.60
KDM6B	activates	entity	0.60
LAMP2	activates	entity	0.60
LC3	activates	entity	0.60
MAP3K5	activates	entity	0.60
MTOR	activates	entity	0.60
NFE2L2	activates	entity	0.60
BDNF	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60
ESR2	associated_with	gene	0.60
NOS2	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
CCL2	regulates	gene	0.60
LC3	interacts_with	gene	0.60
AMPK	activates	entity	0.60
ANXA5	therapeutic_target	gene	0.60
ACHE	therapeutic_target	gene	0.60
INS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MAP3K5	interacts_with	gene	0.60
AKT1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
DRD2	biomarker_for	gene	0.60
ESR1	biomarker_for	gene	0.60
ESR2	biomarker_for	gene	0.60
IL1B	biomarker_for	gene	0.60
IL6	biomarker_for	gene	0.60
NOS2	biomarker_for	gene	0.60
ADIPOQ	activates	gene	0.60
HRAS	regulates	gene	0.60
IGF1	regulates	gene	0.60
MAPK14	regulates	gene	0.60
MMP9	regulates	gene	0.60
ADAMTS1	activates	gene	0.60
CAV1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOS3 in their description or question text

No additional research found