gene

CXCL10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

971Connections

3Hypotheses

6Analyses

50Outgoing

50Incoming

1Experiments

8Debates

Summary

CXCL10 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 545 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CXCL10
Full Name	C-X-C Motif Chemokine Ligand 10
Chromosome	4q21
Function	CXCL10 has essential functions in immune surveillance and inflammation:
Molecular Weight	~10 kDa
Pathways	Akt, Immune Response, Inflammasome, Mapk, Pi3K
NCBI Gene ID	3627
GeneCards	CXCL10
Human Protein Atlas	CXCL10
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	LIRAGLUTIDE
Interactions	ACHE, AD, AGING, AKT, AND, APOPTOSIS
SciDEX Hypotheses	White Matter Oligodendrocyte Protection via CXCL10 White Matter Vulnerability Prevention via Oligoden White Matter Immune Checkpoint Restoration
KG Connections	968 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

🧬 3D Structure: CXCL10 — PDB 1O80 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CXCL10 - C-X-C Motif Chemokine Ligand 10

gene · 619 words

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Pathway Diagram

graph TD
    CXCL10["CXCL10"] -->|"Activates"| microglia["microglia"]
    CXCL10["CXCL10"] -->|"Participates In"| INTERFERON_RESPONSE["INTERFERON_RESPONSE"]
    CXCL10["CXCL10"] -->|"Interacts With"| CXCR3["CXCR3"]
    CXCL10["CXCL10"] -->|"Activates"| Aging["Aging"]
    CXCL10["CXCL10"] -->|"Activates"| Ms["Ms"]
    CXCL10["CXCL10"] -->|"Regulates"| Als["Als"]
    CXCL10["CXCL10"] -->|"Associated With"| Neurodegeneration["Neurodegeneration"]
    CXCL10["CXCL10"] -->|"Expressed In"| Multiple_Sclerosis["Multiple Sclerosis"]
    FIP200["FIP200"] -->|"Inhibits"| CXCL10["CXCL10"]
    IFN_GAMMA["IFN_GAMMA"] -->|"Activates"| CXCL10["CXCL10"]
    A1_ASTROCYTES["A1_ASTROCYTES"] -->|"Expressed In"| CXCL10["CXCL10"]
    CSF2["CSF2"] -->|"Regulates"| CXCL10["CXCL10"]
    NAMPT["NAMPT"] -->|"Regulates"| CXCL10["CXCL10"]
    style CXCL10 fill:#8d4900,color:#e0e0e0
    style microglia fill:#795548,color:#e0e0e0
    style INTERFERON_RESPONSE fill:#9C27B0,color:#e0e0e0
    style CXCR3 fill:#0d47a1,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Multiple_Sclerosis fill:#b71c1c,color:#e0e0e0
    style FIP200 fill:#0d47a1,color:#e0e0e0
    style IFN_GAMMA fill:#0d47a1,color:#e0e0e0
    style A1_ASTROCYTES fill:#795548,color:#e0e0e0
    style CSF2 fill:#8d4900,color:#e0e0e0
    style NAMPT fill:#8d4900,color:#e0e0e0

Outgoing (608)

Target	Relation	Type	Str
Inflammation	activates	disease	0.95
Frailty	biomarker_for	phenotype	0.95
Dermatomyositis	upregulates	disease	0.95
Psoriatic Arthritis	contributes_to	disease	0.92
JAK1/2/STAT1 Signaling	associated_with	pathway	0.90
Dermatomyositis	biomarker_for	disease	0.90
Keratinocyte SPRY1/CXCL10/Periarticular CD14hi Macrophage/TNF-α Axis	mediates	mechanism	0.90
Interferon-Stimulated Response	involved_in	process	0.90
Neuroinflammation	associated_with	process	0.85
T Cell Infiltration	correlates_with	process	0.85
Th1-Type Response	involved_in	process	0.85
Immune Cell Recruitment	mediates	process	0.85
Juvenile Dermatomyositis	biomarker_for	disease	0.85
Frailty	biomarker_for	phenotype	0.85
Als	causes	disease	0.85
CD8+ T cell recruitment	causes (CXCL10 acts as chemokine to recruit cytotoxic CD8+)	mechanism	0.85
Aging	activates	disease	0.85
microglia	activates	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
Immune Cell Recruitment	associated_with	process	0.80
Multiple Sclerosis	associated_with	disease	0.80
CD8+ T cells	associated_with	cell_type	0.80
Autoimmune	therapeutic_target	disease	0.75
Inflammation	associated_with	disease	0.75
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Als	biomarker_for	disease	0.75
Als	therapeutic_target	disease	0.75
Multiple Sclerosis	therapeutic_target	disease	0.75
Als	regulates	disease	0.75
Inflammation	biomarker_for	disease	0.75
Tumor	regulates	disease	0.75
CXCR3	interacts_with	protein	0.72
INTERFERON_RESPONSE	participates_in	pathway	0.72
OPTN	expresses	gene	0.70
STAT3	regulates	gene	0.70
MICROGLIA	interacts_with	cell_type	0.70
STING	biomarker_for	gene	0.70
OPTN	activates	gene	0.70
ENDOTHELIAL	inhibits	cell_type	0.70
MMP9	expresses	gene	0.70
MACROPHAGE	expresses	cell_type	0.70
GASDERMIN	activates	gene	0.70
NEURONS	activates	cell_type	0.70
AGING	regulates	phenotype	0.70
CXCR3	activates	gene	0.70
cd8	activates	protein	0.70
blood-brain barrier	participates_in	pathway	0.70
AGING	activates	gene	0.70
CD8	activates	gene	0.70

Incoming (363)

Source	Relation	Type	Str
SPRY1	inhibits	gene	0.95
A1 Reactive Astrocytes	upregulates	phenotype	0.92
h-245c3e93	targets	hypothesis	0.90
h-c5698ce3	targets	hypothesis	0.90
A1 Astrocytes	associated_with	phenotype	0.90
IFNG	upregulates	protein	0.90
h-724e3929	targets	hypothesis	0.90
A1 Reactive Astrocytes	associated_with	phenotype	0.90
Reactive Astrocytes	upregulates	cell_type	0.90
KCNK2	downregulates	gene	0.85
SNCA	alters	gene	0.80
AΒ1-42	alters	compound	0.80
FIP200	inhibits	protein	0.80
Microglia	upregulates	cell_type	0.80
GENES	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
TNF	activates	gene	0.80
Microglia	associated_with	cell_type	0.78
CCL2	markers	gene	0.70
CX3CL1	biomarker_for	gene	0.70
CCL2	expressed_in	gene	0.70
ACHE	inhibits	gene	0.70
CSF1R	inhibits	gene	0.70
TNF-Α	activates	gene	0.70
CYTOKINES	activates	gene	0.70
ENDOTHELIAL CELLS	inhibits	cell_type	0.70
IL-6	therapeutic_target	gene	0.70
INFLAMMATION	associated_with	gene	0.70
NF-ΚB	activates	gene	0.70
IL-6	activates	gene	0.70
ASTROCYTES	activates	gene	0.70
TNF-Α	therapeutic_target	gene	0.70
INFLAMMATION	biomarker_for	gene	0.70
CYTOKINES	regulates	gene	0.70
STAT1	activates	gene	0.70
CYTOKINES	biomarker_for	gene	0.70
COMPLEMENT	activates	gene	0.70
TNF	therapeutic_target	gene	0.70
LIRAGLUTIDE	inhibits	drug	0.65
KYNURENINE	inhibits	phenotype	0.65
KYNURENINE	activates	phenotype	0.65
TBK1	causes	gene	0.65
CCL2	associated_with	gene	0.65
MACROPHAGE	produces	cell_type	0.65
A1_ASTROCYTES	expressed_in	cell_type	0.64
microglia	regulates	cell_type	0.64
IFN_GAMMA	activates	protein	0.64
MICROGLIA	expressed_in	gene	0.60
CCL2	mediates	gene	0.60
CCL2	interacts_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.675	neurodegeneration	Gene expression changes in aging mouse b
White Matter Vulnerability Prevention via Oligodendrocyte Pr	0.667	neurodegeneration	Gene expression changes in aging mouse b
White Matter Immune Checkpoint Restoration	0.644	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CXCL10 biomarker analysis for CPSP prediction	clinical	chronic postsurgical pain	0.900	0.00	human patients undergoing thor	proposed	N/A

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular ma [PMID:41053177]	Lin B, Zhou J, Geng D, Chai S, Zhang X e	Cell Death Differ	2026
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603]	Ye L, Zhao T, Tian H, Li R, Li Z et al.	Sci China Life Sci	2026
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107]	Lan T, Shang D, Lin L, Wang H, Zou J et	Autophagy	2026
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805]	Nie W, Wang M, Cheng M, Ren Z, Liu G et	J Ethnopharmacol	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958]	Wu W, Cheng Z, Shi P, Gao H, Chen X et a	Bioact Mater	2026
Immune checkpoint inhibitor-associated inflammatory arthritis. [PMID:41800958]	Kim ST, Bass AR	Arthritis Rheumatol	2026
Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188]	Zangas P, Georgakis MK	Curr Atheroscler Rep	2026
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026
Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408]	Tian X, Liu J, Li Y, Wang Y, Luo Y, He H	Nature	2026
HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707]	da Silva MTT, Araujo AQC	Brain : a journal of neurology	2026

Debates (8)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CXCL10 in their description or question text

No additional research found

CXCL10

Understanding Entity Pages

Summary

Wiki Pages (1)

CXCL10 - C-X-C Motif Chemokine Ligand 10

Pathway Diagram

Outgoing (608)

Incoming (363)

Targeting Hypotheses (3)

Mentioning Analyses (6)

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Which cell types show the most significant expression changes for neurodegenerat

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Senolytic therapy for age-related neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (1)

Related Papers (17)

Debates (8)

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

The debate highlighted major safety concerns about blocking CXCL10, particularly

How do peripheral immune system alterations influence CNS pathology and neurodeg

How do peripheral immune system alterations influence CNS pathology and neurodeg

How do peripheral immune system alterations influence CNS pathology and neurodeg

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

The debate mentioned gene expression profiling but did not specify which neural

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research