protein

ATG13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

190Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATG13 is a protein involved in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with Aging, Als, Atherosclerosis. Connected to 104 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATG13
Full Name	Autophagy Related 13
Chromosome	11p11.2
Function	is a critical gene encoding a key regulator of the autophagy initiation machinery in eukaryotic cells.
Molecular Weight	60 kDa
Amino Acids	559 aa
Pathways	Apoptosis, Autophagy, Complement, Ferroptosis, Glycolysis
UniProt ID	[Q9UQL6](https://www.uniprot.org/uniprot/Q9UQL6)
Ensembl ID	ENSG00000152256
OMIM	614608
GeneCards	ATG13
Human Protein Atlas	ATG13
Hor domain (HR)	Located at the N-terminus, mediates protein-protein interactions
LIR (LC3-interacting region)	At the C-terminus, enables binding to LC3/GABARAP family proteins
UBAN-like motif	Facilitates interaction with specific autophagy receptors
Associated Diseases	neurodegeneration
Interactions	AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	190 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATG13 — Autophagy Related 13

gene · 1505 words

→

ATG13 Protein

protein · 968 words

→

Pathway Diagram

graph TD
    ATG13["ATG13"] -->|"regulates"| autophagy["autophagy"]
    ATG13["ATG13"] -->|"contributes to"| Ferroptosis["Ferroptosis"]
    ATG13["ATG13"] -->|"activates"| Cancer["Cancer"]
    ATG13["ATG13"] -->|"interacts"| Als["Als"]
    ATG13["ATG13"] -->|"interacts"| Ms["Ms"]
    ATG13["ATG13"] -->|"interacts"| Parkinson["Parkinson"]
    ATG["ATG"] -->|"component of"| ATG13["ATG13"]
    ATG5["ATG5"] -->|"contributes to"| ATG13["ATG13"]
    ATG3["ATG3"] -->|"contributes to"| ATG13["ATG13"]
    ATG7["ATG7"] -->|"contributes to"| ATG13["ATG13"]
    style ATG13 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (121)

Target	Relation	Type	Str
autophagy	regulates	pathway	0.90
Ferroptosis	contributes_to	process	0.85
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.70
ULK1	interacts_with	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
Autophagy	interacts_with	pathway	0.70
CANCER	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
Cardiovascular	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Tumor	activates	disease	0.65
Dementia	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Ms	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Senescence	activates	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	interacts_with	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
FERROPTOSIS	contributes_to	phenotype	0.64
MTOR	regulates	gene	0.60
PRKAA1	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
ULK1	regulates	gene	0.60
Pi3K	associated_with	pathway	0.60
Stem Cell	associated_with	cell_type	0.60
FIP200	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
BECLIN1	inhibits	gene	0.60
ATG5	regulates	gene	0.60
AND	contributes_to	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
HER2	inhibits	gene	0.60
Amyloid-Beta	inhibits	protein	0.60
ATG5	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
TAX1BP1	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
TBK1	regulates	gene	0.60
ZDHHC13	activates	gene	0.60
FIP200	interacts_with	gene	0.60
ATG101	interacts_with	gene	0.60
PI3KC3	associated_with	gene	0.60

Incoming (69)

Source	Relation	Type	Str
ULK1	associated_with	gene	0.90
ATG	component_of	gene	0.80
TDP-43	inhibits	gene	0.60
HSP70	inhibits	gene	0.60
TAU	inhibits	gene	0.60
ATG16L1	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
HSP90	inhibits	gene	0.60
EIF2A	activates	gene	0.60
HSP27	inhibits	gene	0.60
C9ORF72	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
APP	inhibits	gene	0.60
ATG	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
ATG5	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
BNIP3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
ATG101	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
NBR1	associated_with	gene	0.60
AGING	activates	gene	0.60
AND	implicated_in	gene	0.60
CANCER	activates	gene	0.60
BECN1	contributes_to	gene	0.60
BECLIN1	inhibits	gene	0.60
LC3	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
LIPOPHAGY	activates	gene	0.60
ATG3	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
FERROPTOSIS	activates	gene	0.60
HER2	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ALS	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
AND	regulates	gene	0.60
FIP200	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG13 in their description or question text

No additional research found