gene

TSC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TSC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

350Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

TSC2 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with Als, Atherosclerosis, Autism. Connected to 180 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TSC2
Full Name	Tuberous Sclerosis Complex 2
Function	The TSC1-TSC2 heterodimer localizes primarily to the cytoplasm and intracellular membranes, where it senses cellular energy status and growth factor signals.
Primary Expression	neurons and regulates synaptic function
Subcellular Localization	synapses and regulates dendritic spine morphology and synaptic plasticity
Molecular Weight	200 kDa
Amino Acids	807 aa
Pathways	mTOR, mtor, AMPK, PI3K
Ensembl ID	ENSG00000103197
GeneCards	TSC2
Human Protein Atlas	TSC2
Inhibition of Rheb	The GAP activity of TSC2 converts active GTP-bound Rheb to inactive GDP-bound Rheb, thereby inhibiting mTORC1 activation<sup>[2]</sup>
Energy sensing	TSC2 senses cellular energy (AMP/ATP ratio) through AMPK activation, inhibiting mTORC1 during energy deprivation
Growth factor regulation	PI3K/Akt signaling phosphorylates and inhibits TSC2, allowing mTORC1 activation in response to growth factors
Cell cycle control	TSC2 loss leads to uncontrolled cell proliferation
Associated Diseases	ALS, Diabetes, epilepsy, Ms, neurodegeneration, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	ACETYL-COA, ACTB, Akt, AKT, AKT1, AKT3
KG Connections	350 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TSC2 — Tuberous Sclerosis Complex 2

gene · 995 words

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Pathway Diagram

graph TD
    TSC2["TSC2"]
    TSC2 -->|"inhibits"| mTORC1["mTORC1"]
    TSC2 -->|"regulates"| TFEB["TFEB"]
    TSC2 -->|"inhibits"| MTORC1["MTORC1"]
    TSC2 -->|"binds"| Akt["Akt"]
    TSC2 -->|"inhibits"| mTOR["mTOR"]
    TSC2 -->|"activates"| Ms["Ms"]
    TSC2 -->|"regulates"| Leukemia["Leukemia"]
    TSC2 -->|"regulates"| Als["Als"]
    TSC2 -->|"regulates"| Autism["Autism"]
    TSC2 -->|"activates"| Tumor["Tumor"]
    AKT["AKT"] -->|"phosphorylates"| TSC2
    TSC1["TSC1"] -->|"interacts"| TSC2
    Akt -->|"phosphorylates"| TSC2
    alpha_synuclein["alpha-synuclein"] -->|"interacts"| TSC2
    mTOR -->|"regulates"| TSC2
    EGF["EGF"] -->|"activates"| TSC2
    LC3["LC3"] -->|"activates"| TSC2
    MTOR["MTOR"] -->|"activates"| TSC2

Outgoing (191)

Target	Relation	Type	Str
mTOR Signaling	inhibits	pathway	0.95
mTORC1	inhibits	pathway	0.90
MTOR	activates	gene	0.90
Mtor	activates	pathway	0.90
Mtor	interacts_with	pathway	0.90
Als	interacts_with	disease	0.85
TFEB	regulates	gene	0.85
Akt	binds	protein	0.80
MTORC1	inhibits	protein	0.80
MTORC1	activates	gene	0.80
TSC1	inhibits	gene	0.80
MTOR	interacts_with	gene	0.80
Tumor	activates	disease	0.75
Autism	interacts_with	disease	0.75
Als	inhibits	disease	0.75
Cancer	activates	disease	0.75
Carcinoma	activates	disease	0.75
MTOR	inhibits	gene	0.70
Autophagy	activates	pathway	0.70
MTOR	regulates	gene	0.70
AUTOPHAGY	activates	gene	0.70
mTOR	inhibits	protein	0.70
AKT	activates	gene	0.70
senescence	participates_in	pathway	0.70
Mtor	inhibits	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
TSC1	interacts_with	gene	0.70
GENES	inhibits	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Mtor	regulates	pathway	0.70
Fatty Liver	activates	disease	0.65
Obesity	activates	disease	0.65
Diabetes	activates	disease	0.65
Nafld	activates	disease	0.65
Insulin Resistance	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Epilepsy	interacts_with	disease	0.65
Cardiac	interacts_with	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Als	activates	disease	0.65
Ms	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
Parkinson	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65

Incoming (159)

Source	Relation	Type	Str
pathologic α-synuclein	binds_to	protein	0.95
SNCA	binds	protein	0.90
Akt	inhibits	protein	0.90
Akt	phosphorylates	protein	0.90
TSC1	interacts_with	protein	0.90
AKT	phosphorylates	protein	0.90
AKT	inhibits	protein	0.90
alpha-synuclein	interacts_with	protein	0.85
RPS6	activates	gene	0.70
AKT1	activates	gene	0.70
LYSOSOMAL BIOGENESIS	activates	gene	0.70
SIRT1	activates	gene	0.70
mTOR	regulates	pathway	0.70
SIRT1	modifies	gene	0.70
SIRT1	regulates	gene	0.70
GLUT4	activates	gene	0.65
MTOR	interacts_with	gene	0.60
HEXB	inhibits	gene	0.60
TSC1	activates	gene	0.60
HDAC6	biomarker_for	gene	0.60
MAP1LC3	activates	gene	0.60
DMSO	activates	gene	0.60
AR	activates	gene	0.60
MAPK8	biomarker_for	gene	0.60
TARDBP	associated_with	gene	0.60
FOXO1	activates	gene	0.60
ERN1	activates	gene	0.60
PERK	activates	gene	0.60
HSPA5	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
EEA1	activates	gene	0.60
RNA	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
PI3K	inhibits	gene	0.60
AKT3	activates	gene	0.60
NPRL2	activates	gene	0.60
PIK3CA	activates	gene	0.60
DEPDC5	activates	gene	0.60
NPRL3	activates	gene	0.60
NLGN1	activates	gene	0.60
NLGN1	encodes	gene	0.60
MITOPHAGY	activates	gene	0.60
MTORC1	activates	gene	0.60
IRE1A	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
EPILEPSY	activates	gene	0.60
MTORC1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity