concept

ACETYL-COA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACETYL-COA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

584Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ACETYL-COA is a concept in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 391 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	ACETYL-COA
Key Genes/Proteins	ACAT1, ACC, ACHE, ACLY, Actin, AGING
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Alpha-Synuclein

Pathway Diagram

graph TD
    ACETYL_COA["ACETYL-COA"]
    ACETYL_COA -->|"activates"| STAT3["STAT3"]
    ACETYL_COA -->|"activates"| histone_acetylation["histone acetylation"]
    ACETYL_COA -->|"activates"| Tumor["Tumor"]
    ACETYL_COA -->|"activates"| Ms["Ms"]
    ACETYL_COA -->|"activates"| Als["Als"]
    ACETYL_COA -->|"inhibits"| Cardiovascular["Cardiovascular"]
    ACETYL_COA -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACETYL_COA -->|"interacts"| Alzheimer["Alzheimer"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ACETYL_COA
    AMPK["AMPK"] -->|"activates"| ACETYL_COA
    BNIP3["BNIP3"] -->|"activates"| ACETYL_COA
    BCL2["BCL2"] -->|"activates"| ACETYL_COA
    GLI1["GLI1"] -->|"activates"| ACETYL_COA
    ATG["ATG"] -->|"activates"| ACETYL_COA
    BECN1["BECN1"] -->|"activates"| ACETYL_COA
    ATG7["ATG7"] -->|"activates"| ACETYL_COA
    PIK3C3["PIK3C3"] -->|"activates"| ACETYL_COA
    MITOPHAGY["MITOPHAGY"] -->|"activates"| ACETYL_COA

Outgoing (365)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.95
Cancer	activates	disease	0.95
STAT3	activates	gene	0.90
EP300	activates	protein	0.90
Tumor	inhibits	disease	0.85
P300	activates	protein	0.85
STAT3	activates	protein	0.85
Inflammation	activates	disease	0.85
Tumor	activates	disease	0.85
Obesity	activates	disease	0.85
Als	activates	disease	0.85
histone acetylation	activates	phenotype	0.80
Autophagy	activates	pathway	0.80
CANCER	activates	gene	0.80
ATP	activates	gene	0.80
MICROGLIA	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
Als	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
microglial_activation	modulates	mechanism	0.75
Lung Cancer	inhibits	disease	0.75
Mitophagy	activates	pathway	0.70
CANCER	inhibits	gene	0.70
Invasion	inhibits	pathway	0.70
Mtor	inhibits	pathway	0.70
STAT3	activates	protein	0.70
STAT3	regulates	protein	0.70
AMPK	activates	gene	0.70
Angiogenesis	inhibits	pathway	0.70
Epigenetic	regulates	pathway	0.70
Glycolysis	activates	pathway	0.70
Oxidative Phosphorylation	activates	pathway	0.70
GENES	activates	gene	0.70
Autophagy	regulates	pathway	0.70
Lipid Metabolism	associated_with	pathway	0.70
MITOCHONDRIA	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
Cardiac	activates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Lung Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Ataxia	activates	disease	0.65
Senescence	activates	disease	0.65
Tumor	regulates	disease	0.65

Incoming (219)

Source	Relation	Type	Str
CANCER	inhibits	gene	0.70
MITOPHAGY	activates	gene	0.70
SIRT1	activates	gene	0.70
BNIP3	activates	gene	0.60
BCL2	activates	gene	0.60
GLI1	activates	gene	0.60
ATG	activates	gene	0.60
BECN1	activates	gene	0.60
ATG7	activates	gene	0.60
KRAS	inhibits	gene	0.60
ACC	therapeutic_target	gene	0.60
ACAT1	interacts_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
GFP	inhibits	gene	0.60
TFEB	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
PARKINSON'S DISEASE	protects_against	gene	0.60
APOPTOSIS	protects_against	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
PARKINSON	protects_against	gene	0.60
NEURODEGENERATIVE DISEASES	protects_against	gene	0.60
MITOCHONDRIAL DYSFUNCTION	protects_against	gene	0.60
PARKINSON	activates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
COMPLEMENT	inhibits	gene	0.60
MTOR	associated_with	gene	0.60
P62	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TP53	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
RB1	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
ATG	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
MICRORNAS	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
APOPTOSIS	inhibits	gene	0.60
STAT3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACETYL-COA in their description or question text

No additional research found