concept

ACLY

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ACLY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections

0Hypotheses

0Analyses

50Outgoing

31Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ACLY
Key Genes/Proteins	A53T, ACC, ACETYL-COA, ACETYL_COA, Akt, AKT
Related Pathways	Alpha-Synuclein, Apoptosis, Autophagy

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ACLY Inhibition Rescues Alpha-Synuclein Autophagy

mechanism · 2109 words

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Pathway Diagram

graph TD
    ACLY["ACLY"]
    ACLY -->|"catalyzes"| Acetyl_CoA["Acetyl-CoA"]
    ACLY -->|"activates"| p300["p300"]
    ACLY -->|"involved_in"| Parkinson_s_Disease["Parkinson's Disease"]
    ACLY -->|"involved_in"| De_Novo_Fatty_Acid_Synthesis["De Novo Fatty Acid Synthesis"]
    ACLY -->|"modifies"| LKB1["LKB1"]
    alpha_synuclein["alpha-synuclein"] -->|"activates"| ACLY
    SNCA["SNCA"] -->|"activates"| ACLY
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"activates"| ACLY
    SREBP1["SREBP1"] -->|"regulates"| ACLY
    A53T["A53T"] -->|"activates"| ACLY
    FBXW7["FBXW7"] -->|"modulates"| ACLY
    LKB1 -->|"activates"| ACLY
    PARKINSON["PARKINSON"] -->|"activates"| ACLY

Outgoing (78)

Target	Relation	Type	Str
p300	activates	protein	0.90
De Novo Fatty Acid Synthesis	involved_in	process	0.88
LKB1	modifies	protein	0.85
High-Carbohydrate Diet	upregulates	drug	0.85
AMPK	inhibits	protein	0.80
ACETYL_COA	catalyzes	protein	0.72
ATP	activates	gene	0.70
Parkinson	activates	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
LKB1	regulates	protein	0.64
ACETYL-COA	activates	gene	0.60
MTORC1	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
ALPHA-SYNUCLEIN	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
Alpha-Synuclein	inhibits	pathway	0.60
Mtor	activates	pathway	0.60
LC3	activates	gene	0.60
neurons	expressed_in	cell_type	0.60
FBXW7	activates	gene	0.60
lipid metabolism	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
HK2	activates	gene	0.60
LDHA	activates	gene	0.60
PKM2	activates	gene	0.60
SLC1A5	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
LKB1	activates	gene	0.60
GLS	activates	gene	0.60
SNCA	activates	gene	0.60
PARKINSON	activates	gene	0.60
Neuron	therapeutic_target	cell_type	0.60
CANCER	activates	gene	0.60
PI3K	activates	gene	0.60
RAPTOR	activates	gene	0.60
GLUT1	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
AND	activates	gene	0.60
Raf	therapeutic_target	protein	0.60
Rb	activates	protein	0.60
Raf	activates	protein	0.60
Akt	activates	protein	0.60
LAMP1	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
Lipid Metabolism	inhibits	pathway	0.60

Incoming (31)

Source	Relation	Type	Str
SREBP1	regulates	protein	0.90
alpha-synuclein	activates	protein	0.90
A53T	activates	protein	0.72
LC3	activates	gene	0.60
GFP	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
SREBP1	activates	gene	0.60
RNA	activates	gene	0.60
FBXW7	modulates	protein	0.60
ACETYL-COA	activates	gene	0.60
ALPHA-SYNUCLEIN	inhibits	gene	0.60
MTORC1	activates	gene	0.60
ACC	activates	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
FBXW7	regulates	gene	0.60
NF-ΚB	activates	gene	0.60
ATP	contributes_to	gene	0.60
UBIQUITIN	regulates	gene	0.60
AND	contributes_to	gene	0.60
HIF	regulates	gene	0.60
CANCER	activates	gene	0.60
PI3K	activates	gene	0.60
LKB1	activates	gene	0.60
PARKINSON	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
RAPTOR	activates	gene	0.60
ATP	activates	gene	0.60
AMPK	activates	gene	0.60
AND	activates	gene	0.60
rapamycin	targets	drug	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACLY in their description or question text

No additional research found