concept

IRE1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRE1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

35Outgoing

20Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IRE1A
Key Genes/Proteins	ACETYL-COA, AKT, AND, APOPTOSIS, AUTOPHAGY, BIP
Related Diseases	Als
Related Pathways	Akt, Apoptosis, Autophagy, browning, Cholesterol

Pathway Diagram

graph TD
    IRE1A["IRE1A"]
    IRE1A -->|"inhibits"| PPARGC1A["PPARGC1A"]
    IRE1A -->|"inhibits"| thermogenesis["thermogenesis"]
    IRE1A -->|"activates"| Inflammation["Inflammation"]
    IRE1A -->|"activates"| Als["Als"]
    IRE1A -->|"activates"| Hepatitis["Hepatitis"]
    IRE1A -->|"inhibits"| lipolysis["lipolysis"]
    IRE1A -->|"inhibits"| browning["browning"]
    IRE1A -->|"activates"| obesity["obesity"]
    IRE1A -->|"inhibits"| beige_adipocytes["beige_adipocytes"]
    IRE1A -->|"inhibits"| Cholesterol["Cholesterol"]
    XBP1["XBP1"] -->|"activates"| IRE1A
    GENES["GENES"] -->|"activates"| IRE1A
    ERN1["ERN1"] -->|"activates"| IRE1A
    PIK3C3["PIK3C3"] -->|"activates"| IRE1A
    MITOPHAGY["MITOPHAGY"] -->|"activates"| IRE1A
    YWHAG["YWHAG"] -->|"activates"| IRE1A
    RICTOR["RICTOR"] -->|"activates"| IRE1A
    AKT["AKT"] -->|"activates"| IRE1A
    ENDOG["ENDOG"] -->|"activates"| IRE1A
    MTORC1["MTORC1"] -->|"activates"| IRE1A

Outgoing (35)

Target	Relation	Type	Str
PPARGC1A	degrades	gene	0.95
Adaptive Thermogenesis	inhibits	process	0.92
Beige Adipocyte Activation	inhibits	process	0.90
Lipolysis	inhibits	process	0.88
Obesity	contributes_to	disease	0.85
PPARGC1A	inhibits	gene	0.72
thermogenesis	inhibits	pathway	0.72
Hepatitis	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
beige_adipocytes	inhibits	cell_type	0.64
lipolysis	inhibits	pathway	0.64
browning	inhibits	pathway	0.64
obesity	activates	disease	0.64
MITOCHONDRIA	activates	gene	0.60
RICTOR	activates	gene	0.60
AND	activates	gene	0.60
YWHAG	activates	gene	0.60
MTORC1	activates	gene	0.60
BIP	activates	gene	0.60
Unfolded Protein Response	activates	pathway	0.60
Cholesterol	inhibits	pathway	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TSC2	activates	gene	0.60
EIF2AK3	activates	gene	0.60
GSK3B	activates	gene	0.60
ERN1	activates	gene	0.60
HSPA5	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
Autophagy	activates	pathway	0.60
Akt	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Mtor	activates	pathway	0.60
Mitophagy	activates	pathway	0.60

Incoming (20)

Source	Relation	Type	Str
Endoplasmic Reticulum Stress	activates	process	0.85
MITOPHAGY	activates	gene	0.60
YWHAG	activates	gene	0.60
RICTOR	activates	gene	0.60
PIK3C3	activates	gene	0.60
ENDOG	activates	gene	0.60
MTORC1	activates	gene	0.60
BIP	activates	gene	0.60
AKT	activates	gene	0.60
XBP1	activates	gene	0.60
GENES	activates	gene	0.60
ERN1	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
PERK	activates	gene	0.60
HSPA5	activates	gene	0.60
TSC2	activates	gene	0.60
GSK3B	activates	gene	0.60
EIF2AK3	activates	gene	0.60
DNA	activates	gene	0.60
ACETYL-COA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRE1A in their description or question text

No additional research found