gene

BIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

187Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

6Experiments

0Debates

Summary

BIP (HSPA5/GRP78) is a major ER chaperone and key regulator of the unfolded protein response in neurodegeneration

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🧬 Gene Info

Gene Symbol	BIP
Full Name	Binding Immunoglobulin Protein
Aliases	HSPA5/GRP78
Protein Type	Protein
Function	De Novo Folding: Binds nascent polypeptide chains as they enter the ER via the Sec61 translocon
Subcellular Localization	the ER lumen. Its primary functions include:
Molecular Weight	78 kDa
Amino Acids	654 aa
Pathways	Autophagy, Mapk, Mtor, Pi3K/Akt, Unfolded Protein Response
UniProt ID	P11021
GeneCards	BIP
Human Protein Atlas	BIP
Protein folding assistance	BIP binds to nascent polypeptides and ensures proper folding by preventing aggregation
ER quality control	BIP monitors protein folding status and targets misfolded proteins for degradation
UPR regulation	BIP acts as the primary sensor for ER stress, controlling activation of three UPR branches:
Associated Diseases	Tumor
Interactions	ACETYL-COA, AKT, AND, ANXIETY, APOPTOSIS, ARC
KG Connections	181 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BIP — AlphaFold P11021 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BIP — Binding Immunoglobulin Protein

gene · 2512 words

→

CTNNBIP1 Gene — Catenin Beta Interacting Protein 1 (ICAT)

gene · 1760 words

→

Pathway Diagram

flowchart TD
    BIP["BIP"] -->|"activates"| Als["Als"]
    BIP["BIP"] -->|"activates"| Ms["Ms"]
    BIP["BIP"] -->|"regulates"| Ms["Ms"]
    BIP["BIP"] -->|"regulates"| Cancer["Cancer"]
    BIP["BIP"] -->|"activates"| Tumor["Tumor"]
    BIP["BIP"] -->|"interacts with"| Ms["Ms"]
    BIP["BIP"] -->|"therapeutic target"| Ms["Ms"]
    BIP["BIP"] -->|"therapeutic target"| Neurodegeneration["Neurodegeneration"]
    BIP["BIP"] -.->|"inhibits"| Cancer["Cancer"]
    BIP["BIP"] -->|"associated with"| Tumor["Tumor"]
    BIP["BIP"] -->|"activates"| ALS["ALS"]
    BIP["BIP"] -->|"activates"| JNK1["JNK1"]
    style BIP fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style JNK1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (120)

Target	Relation	Type	Str
IRF2BP2	interacts_with	protein	0.95
IRF2BP2	degrades	protein	0.90
ER stress	biomarker_for	process	0.90
Endoplasmic Reticulum Stress Response	involved_in	process	0.85
Inflammation	activates	disease	0.85
Als	activates	disease	0.85
Er Stress	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Tumor	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Apoptosis	activates	pathway	0.70
CHOP	activates	gene	0.70
Unfolded Protein Response	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Schizophrenia	expressed_in	disease	0.65
Bipolar	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	interacts_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Cancer	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	regulates	disease	0.65
Obesity	regulates	disease	0.65
Nafld	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Fatty Liver	regulates	disease	0.65
Als	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Senescence	activates	disease	0.65
Anxiety	activates	disease	0.65
Obesity	activates	disease	0.65
ALS	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
GBA1	activates	gene	0.60
AND	inhibits	gene	0.60
PARKINSON'S DISEASE	biomarker_for	gene	0.60
Complement	inhibits	pathway	0.60
ATF6	interacts_with	gene	0.60
Wnt	inhibits	pathway	0.60
HSPA5	associated_with	gene	0.60
MUL1	inhibits	gene	0.60
Mtor	regulates	pathway	0.60
Mapk	regulates	pathway	0.60

Incoming (67)

Source	Relation	Type	Str
Malate	binds	compound	0.95
KDEL	binds	protein	0.90
Succinate	binds	compound	0.85
AUTOPHAGY	activates	gene	0.70
ROS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
UBIQUITIN	inhibits	gene	0.60
NTS	inhibits	gene	0.60
PI3K	regulates	gene	0.60
PLIN2	activates	gene	0.60
FOS	activates	gene	0.60
STAT3	activates	gene	0.60
BDNF	activates	gene	0.60
MMP2	activates	gene	0.60
ARC	activates	gene	0.60
PTEN	activates	gene	0.60
IL6	activates	gene	0.60
MMP9	activates	gene	0.60
NGF	activates	gene	0.60
IGF1	activates	gene	0.60
BAX	activates	gene	0.60
BAX	inhibits	gene	0.60
C-JUN	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
MTORC1	activates	gene	0.60
NFKB	inhibits	gene	0.60
LYSOSOME	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
ANXIETY	activates	gene	0.60
GENES	activates	gene	0.60
DGAT2	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
GFP	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
JUN	activates	gene	0.60
PARKINSON'S DISEASE	biomarker_for	gene	0.60
JNK1	activates	gene	0.60
GAIN	activates	gene	0.60
PERK	activates	gene	0.60
SQSTM1	activates	gene	0.60
ERN1	activates	gene	0.60
HSPA5	activates	gene	0.60
TSC2	activates	gene	0.60
GSK3B	activates	gene	0.60
EIF2AK3	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
STROKE	activates	gene	0.60
DNA	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
IRE1A	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Biphasic Ketogenic Intervention Protocol	0.773	metabolic neuroscience	What determines the optimal timing and d
Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement F	0.518	synaptic biology	Does SPP1-mediated synaptic engulfment r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Mobile App-Based Intervention for BPSD in Community-Dwelling Dementia	clinical	dementia with behavioral and p	0.950	human patients	proposed	N/A
AECII-specific HMGCS2 overexpression in mouse pulmonary fibrosis	validation	idiopathic pulmonary fibrosis	0.950	C57BL/6 mice with AECII-specif	proposed	N/A
Ketogenic diet fat threshold analysis in wild-type mice	validation	metabolic disease	0.900	C57BL/6J wild-type mice	proposed	N/A
HMGCS2 gain-of-function in AECII lipid metabolism regulation	exploratory	idiopathic pulmonary fibrosis	0.900	human AECIIs	proposed	N/A
Ketogenic diet efficacy in diet-induced obese mice	validation	obesity, metabolic disease	0.900	C57BL/6J diet-induced obese mi	proposed	N/A
Microarray and single-cell RNA analysis of lipid metabolism genes	exploratory	idiopathic pulmonary fibrosis	0.850	human patients, mouse models	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BIP in their description or question text

No additional research found