gene

GLI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

0Experiments

0Debates

Summary

Comprehensive guide to GLI1 transcription factor in Hedgehog signaling and its role in neurodegeneration

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🧬 Gene Info

Gene Symbol	GLI1
Full Name	GLI Family Zinc Finger 1
Chromosome	12q13.2
Protein Family	GLI transcription factors
Protein Type	Transcription Factor
Function	is a transcription factor that serves as the primary effector of the Hedgehog (HH) signaling pathway
Pathways	NOTCH
UniProt ID	P08151
NCBI Gene ID	2735
Ensembl ID	ENSG00000111087
OMIM	165220
GeneCards	GLI1
Human Protein Atlas	GLI1
Associated Diseases	ALS
Known Drugs/Compounds	metformin
Interactions	ACETYL-COA, AKT, AND, APOPTOSIS, ATG, ATG7
KG Connections	111 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GLI1 — AlphaFold P08151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GLI1 — GLI Family Zinc Finger 1

gene · 3218 words

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Pathway Diagram

graph TD
    GLI1["GLI1"]
    AUTOPHAGY(["AUTOPHAGY"])
    GLI1 -->|"regulates"| AUTOPHAGY
    Ms{"Ms"}
    GLI1 -->|"activates"| Ms
    GLI1 -->|"regulates"| Ms
    Als{"Als"}
    GLI1 -->|"regulates"| Als
    ALS{"ALS"}
    GLI1 -->|"regulates"| ALS
    BCL2["BCL2"]
    GLI1 -->|"associated with"| BCL2
    Hedgehog(["Hedgehog"])
    GLI1 -->|"activates"| Hedgehog
    Autophagy(["Autophagy"])
    GLI1 -->|"activates"| Autophagy
    PDGFRB["PDGFRB"]
    GLI1 -->|"regulates"| PDGFRB
    PDGFRA["PDGFRA"]
    GLI1 -->|"regulates"| PDGFRA
    ATG["ATG"]
    GLI1 -->|"activates"| ATG
    ATG7["ATG7"]
    GLI1 -->|"activates"| ATG7
    BNIP3["BNIP3"]
    BNIP3 -->|"activates"| GLI1
    BECN1["BECN1"]
    BECN1 -->|"associated with"| GLI1
    ATG7 -->|"activates"| GLI1
    ATG -->|"activates"| GLI1
    BCL2 -->|"associated with"| GLI1
    ATG12["ATG12"]
    ATG12 -->|"expressed in"| GLI1
    PDGFRA -->|"regulates"| GLI1
    THBS2["THBS2"]
    THBS2 -->|"regulates"| GLI1
    ACETYL_COA["ACETYL-COA"]
    ACETYL_COA -->|"activates"| GLI1
    AUTOPHAGY -->|"activates"| GLI1
    AND["AND"]
    AND -->|"activates"| GLI1
    style GLI1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (72)

Target	Relation	Type	Str
AUTOPHAGY	regulates	pathway	0.72
Hedgehog	activates	pathway	0.70
Ms	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Colorectal Cancer	activates	disease	0.65
Fibrosis	activates	disease	0.65
Als	regulates	disease	0.65
Cirrhosis	activates	disease	0.65
ALS	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	activates	disease	0.65
ALS	regulates	disease	0.65
HSPG2	expressed_in	gene	0.60
ACETYL-COA	activates	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
AUTOPHAGY-RELATED GENES	expressed_in	gene	0.60
Autophagy	expressed_in	pathway	0.60
Neurogenesis	expressed_in	pathway	0.60
THBS2	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Endothelial	activates	cell_type	0.60
Stem Cell	regulates	cell_type	0.60
Hedgehog	expressed_in	pathway	0.60
Tgf-Β	activates	pathway	0.60
Nf-Kb	activates	pathway	0.60
GLI2	activates	gene	0.60
BNIP3	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
HMGCR	activates	gene	0.60
SHH	inhibits	gene	0.60
Hedgehog Signaling	expressed_in	pathway	0.60
Rb	activates	protein	0.60
Rb	regulates	protein	0.60
MYC	inhibits	gene	0.60
Autophagy	activates	pathway	0.60
ATG	activates	gene	0.60
P53	activates	gene	0.60
AND	activates	gene	0.60
HEDGEHOG	activates	gene	0.60
HEDGEHOG	expressed_in	gene	0.60
Ras	activates	protein	0.60
Pdgf	regulates	protein	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ALS	associated_with	disease	0.60

Incoming (39)

Source	Relation	Type	Str
PDGF	regulates	gene	0.60
metformin	targets	drug	0.60
BNIP3	activates	gene	0.60
BECN1	associated_with	gene	0.60
ATG7	activates	gene	0.60
ATG12	expressed_in	gene	0.60
PDGFRA	regulates	gene	0.60
PDGFRB	regulates	gene	0.60
ACETYL-COA	activates	gene	0.60
AND	activates	gene	0.60
HEDGEHOG	expressed_in	gene	0.60
BCL2	regulates	entity	0.60
BCL2	activates	gene	0.60
BECN1	regulates	entity	0.60
BNIP3	regulates	entity	0.60
C-MYC	activates	gene	0.60
CANCER	activates	gene	0.60
ITGB1	activates	gene	0.60
IL-6	activates	gene	0.60
NF-KB	activates	gene	0.60
P53	activates	gene	0.60
GLI	activates	gene	0.60
HSPG2	expressed_in	gene	0.60
SHH	inhibits	gene	0.60
AKT	activates	gene	0.60
MYC	activates	gene	0.60
NRP1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
THBS2	regulates	gene	0.60
CANCER	inhibits	gene	0.60
ATG	activates	gene	0.60
BCL2	associated_with	gene	0.60
HEDGEHOG	activates	gene	0.60
AND	expressed_in	gene	0.60
BECN1	activates	gene	0.50
GLI	co_expressed_with	gene	0.50
Autophagy	activates	process	0.50
BRD4	co_expressed_with	gene	0.50
BNIP3	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLI1 in their description or question text

No additional research found