protein

VHL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VHL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

280Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

VHL is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, contributes to. Associated with ALS, Als, Cancer. Connected to 191 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	VHL
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most tissues:
Molecular Weight	19.5 kDa
Pathways	Mtor, Pi3K, Dna Methylation, Akt, Angiogenesis
Ensembl ID	ENSG00000196511
GeneCards	VHL
Human Protein Atlas	VHL
Normoxia	VHL binds to hydroxylated HIF-α (HIF1A/HIF2A), leading to polyubiquitination and degradation
Hypoxia	HIF-α escapes hydroxylation, escapes VHL-mediated degradation, and translocates to the nucleus
Target genes	VEGF, EPO, GLUT1, and other genes involved in oxygen homeostasis[@schofield2004]
Extracellular matrix maintenance	VHL regulates fibronectin matrix assembly
Microtubule stabilization	VHL interacts with microtubules
Ciliogenesis	VHL is required for primary cilia formation
DNA repair	VHL participates in DNA damage response[@gossage2010]
Associated Diseases	Als, cancer, Carcinoma, Cardiovascular
Interactions	ACETYL-COA, ACLY, AKT, AND, APOE4, ATG14L
KG Connections	280 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VHL Gene

gene · 647 words

→

VHL Protein

protein · 670 words

→

Pathway Diagram

graph TD
    VHL["VHL"]
    VHL -->|"regulates"| HIF["HIF"]
    VHL -->|"activates"| Cardiovascular["Cardiovascular"]
    VHL -->|"activates"| Cardiac["Cardiac"]
    VHL -->|"activates"| Tumor["Tumor"]
    VHL -->|"activates"| Ms["Ms"]
    VHL -->|"expressed in"| Cancer["Cancer"]
    VHL -->|"expressed in"| Carcinoma["Carcinoma"]
    VHL -->|"regulates"| Als["Als"]
    TCEB1["TCEB1"] -->|"interacts"| VHL
    MTOR["MTOR"] -->|"activates"| VHL
    IDH1["IDH1"] -->|"activates"| VHL
    PI3K["PI3K"] -->|"expressed in"| VHL
    DNA["DNA"] -->|"expressed in"| VHL
    NRF2["NRF2"] -->|"expressed in"| VHL
    KEAP1["KEAP1"] -->|"expressed in"| VHL
    P53["P53"] -->|"expressed in"| VHL
    AKT["AKT"] -->|"expressed in"| VHL

Outgoing (207)

Target	Relation	Type	Str
Clear-Cell Renal Cell Carcinoma	associated_with	disease	0.95
Clear Cell Renal Cell Carcinoma	drives	disease	0.95
Clear Cell Renal Cell Carcinoma	risk_factor_for	disease	0.95
HIF	degrades	protein	0.95
HIF1A	degrades	protein	0.93
Proteolysis	mediates	process	0.90
VHL-Loss-Driven phenotype	mediates	phenotype	0.90
kidney tumorigenesis	protects_against	process	0.90
CANCER	activates	gene	0.90
Carcinoma	activates	disease	0.85
Tumor	activates	disease	0.85
PBRM1	associated_with	gene	0.85
Cancer	activates	disease	0.85
Als	activates	disease	0.85
CLEAR CELL RENAL CELL CARCINOMA	causes	disease	0.80
Kidney Cancer	causes	disease	0.80
Mtor	activates	pathway	0.80
MTOR	activates	protein	0.80
HIF	activates	gene	0.80
mTOR	activates	protein	0.75
Cancer	causes	disease	0.75
Tumor	inhibits	disease	0.75
Renal Cell Carcinoma	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
MTOR Pathway Activity	associated_with	process	0.75
Als	therapeutic_target	disease	0.75
HIF	regulates	protein	0.72
CANCER	causes	gene	0.70
AKT	activates	gene	0.70
AKT	contributes_to	gene	0.70
Ms	interacts_with	disease	0.65
Ms	activates	disease	0.65
Cancer	associated_with	disease	0.65
Obesity	activates	disease	0.65
Inflammation	activates	disease	0.65
Insulin Resistance	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Cardiac	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Tumor	degrades	disease	0.65
Cancer	degrades	disease	0.65
ALS	degrades	disease	0.65
Tumor	regulates	disease	0.65
ALS	causes	disease	0.65
Ischemia	activates	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65

Incoming (73)

Source	Relation	Type	Str
ELOC	interacts_with	protein	0.90
PBRM1	interacts_with	protein	0.75
PTEN	contributes_to	gene	0.70
TCEB1	interacts_with	gene	0.64
P53	therapeutic_target	gene	0.60
PHD2	interacts_with	gene	0.60
VEGF	activates	gene	0.60
HIF1	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
HIF1	activates	gene	0.60
AND	expressed_in	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
EPO	activates	gene	0.60
HIF	activates	gene	0.60
MTOR	activates	gene	0.60
STAT3	associated_with	gene	0.60
ARID1A	contributes_to	gene	0.60
MDM2	regulates	gene	0.60
DNA	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
HIF	expressed_in	gene	0.60
IDH1	activates	gene	0.60
PTEN	implicated_in	gene	0.60
BECLIN1	inhibits	gene	0.60
UBIQUITIN	activates	gene	0.60
MDM2	interacts_with	gene	0.60
SNF	causes	gene	0.60
SWI	causes	gene	0.60
HIF	causes	gene	0.60
CANCER	causes	gene	0.60
TCEB1	causes	gene	0.60
CANCER	expressed_in	gene	0.60
ATG14L	inhibits	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
ACETYL-COA	contributes_to	gene	0.60
GENES	degrades	gene	0.60
AND	interacts_with	gene	0.60
APOPTOSIS	degrades	gene	0.60
CANCER	degrades	gene	0.60
P53	degrades	gene	0.60
NF-ΚB	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
NRF2	expressed_in	gene	0.60
KEAP1	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
CUL3	expressed_in	gene	0.60
STK11	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VHL in their description or question text

No additional research found