concept

ACETYL-COA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACETYL-COA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

589Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

ACETYL-COA is a concept in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 391 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACETYL-COA
Key Genes/Proteins	ACAT1, ACC, ACHE, ACLY, Actin, AGING
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Alpha-Synuclein

Pathway Diagram

graph TD
    ACETYL_COA["ACETYL-COA"]
    ACETYL_COA -->|"activates"| STAT3["STAT3"]
    ACETYL_COA -->|"activates"| histone_acetylation["histone acetylation"]
    ACETYL_COA -->|"activates"| Tumor["Tumor"]
    ACETYL_COA -->|"activates"| Ms["Ms"]
    ACETYL_COA -->|"activates"| Als["Als"]
    ACETYL_COA -->|"inhibits"| Cardiovascular["Cardiovascular"]
    ACETYL_COA -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACETYL_COA -->|"interacts"| Alzheimer["Alzheimer"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ACETYL_COA
    AMPK["AMPK"] -->|"activates"| ACETYL_COA
    BNIP3["BNIP3"] -->|"activates"| ACETYL_COA
    BCL2["BCL2"] -->|"activates"| ACETYL_COA
    GLI1["GLI1"] -->|"activates"| ACETYL_COA
    ATG["ATG"] -->|"activates"| ACETYL_COA
    BECN1["BECN1"] -->|"activates"| ACETYL_COA
    ATG7["ATG7"] -->|"activates"| ACETYL_COA
    PIK3C3["PIK3C3"] -->|"activates"| ACETYL_COA
    MITOPHAGY["MITOPHAGY"] -->|"activates"| ACETYL_COA

Outgoing (370)

Target	Relation	Type	Str
Cancer	activates	disease	0.95
Cancer	inhibits	disease	0.95
EP300	activates	protein	0.90
STAT3	activates	gene	0.90
histone acetylation	modulates	epigenetic_modification	0.90
histone acetylation	regulates	phenotype	0.90
Tumor	activates	disease	0.85
P300	activates	protein	0.85
Als	activates	disease	0.85
STAT3	activates	protein	0.85
Tumor	inhibits	disease	0.85
Obesity	activates	disease	0.85
Inflammation	activates	disease	0.85
histone acetylation	activates	phenotype	0.80
Autophagy	activates	pathway	0.80
AUTOPHAGY	activates	gene	0.80
MICROGLIA	activates	gene	0.80
ATP	activates	gene	0.80
CANCER	activates	gene	0.80
Lung Cancer	inhibits	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Als	regulates	disease	0.75
microglial_activation	modulates	mechanism	0.75
Autophagy	regulates	pathway	0.70
AUTOPHAGY	regulates	gene	0.70
Lipid Metabolism	associated_with	pathway	0.70
Angiogenesis	inhibits	pathway	0.70
CANCER	inhibits	gene	0.70
Mitophagy	activates	pathway	0.70
AMPK	activates	gene	0.70
Invasion	inhibits	pathway	0.70
Epigenetic	regulates	pathway	0.70
Oxidative Phosphorylation	activates	pathway	0.70
Glycolysis	activates	pathway	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
MITOCHONDRIA	activates	gene	0.70
STAT3	activates	protein	0.70
GENES	activates	gene	0.70
Mtor	inhibits	pathway	0.70
STAT3	regulates	protein	0.70
Chromatin Accessibility	regulates	phenotype	0.70
chromatin regulators	regulates	protein	0.70
chromatin regulators	modulates	process	0.70
Neuroinflammation	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Ischemia	protects_against	disease	0.65
Senescence	activates	disease	0.65
Parkinson	protects_against	disease	0.65
Huntington	interacts_with	disease	0.65

Incoming (219)

Source	Relation	Type	Str
CANCER	inhibits	gene	0.70
SIRT1	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
YWHAG	activates	gene	0.60
RICTOR	activates	gene	0.60
AKT	activates	gene	0.60
ENDOG	activates	gene	0.60
MTORC1	activates	gene	0.60
BIP	activates	gene	0.60
IRE1A	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TSC2	activates	gene	0.60
EIF2AK3	activates	gene	0.60
GSK3B	activates	gene	0.60
ERN1	activates	gene	0.60
HSPA5	activates	gene	0.60
APOE3	regulates	gene	0.60
MIRNAS	contributes_to	gene	0.60
APOE4	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
APOE	contributes_to	gene	0.60
MICRORNAS	contributes_to	gene	0.60
PDK1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
P62	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TP53	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
RB1	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
ATG	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
TP53	treats	gene	0.60
CANCER	treats	gene	0.60
DNA	inhibits	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
MICRORNAS	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
PARKINSON'S DISEASE	protects_against	gene	0.60
APOPTOSIS	protects_against	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
PARKINSON	protects_against	gene	0.60
NEURODEGENERATIVE DISEASES	protects_against	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do different priming stimuli require distinct therapeutic approaches or share co

immunology | 2026-04-08 | 1 hypotheses Top: 0.380

Do microglia actually switch between glycolytic and oxidative phosphorylation as

neuroinflammation | 2026-04-07 | 7 hypotheses Top: 0.609

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The circadian hypothesis assumes metabolic switching drives microglial priming,

closed · Rounds: 4 · Score: 0.66 · 2026-04-21

Do different priming stimuli require distinct therapeutic approaches or share co

closed · Rounds: 4 · Score: 0.93 · 2026-04-10

Related Research

Hypotheses and analyses mentioning ACETYL-COA in their description or question text

No additional research found