protein

ENDOG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

4Hypotheses

0Analyses

50Outgoing

16Incoming

0Experiments

0Debates

Summary

ENDOG is a protein involved in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als. Connected to 23 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ENDOG
Full Name	Endonuclease G, Mitochondrial
Aliases	Endonuclease G
Chromosome	9q34.11
Function	ENDOG (Endonuclease G) is a mitochondrial nuclease that plays important roles in both mitochondrial DNA maintenance and apoptosis.
Primary Expression	most tissues, with high expression in tissues containing high numbers of mitochondria
Subcellular Localization	, linking it to stress-response kinase cascades including JNK and p38 MAPK pathways. Additionally, ENDOG participates in
Molecular Weight	30 kDa
Amino Acids	27 aa
Pathways	Akt, Apoptosis, Autophagy, Mitophagy, Mtor
UniProt ID	[O95071](https://www.uniprot.org/uniprot/O95071)
Ensembl ID	ENSG00000167136
OMIM	601060
GeneCards	ENDOG
Human Protein Atlas	ENDOG
Associated Diseases	neurodegeneration
Interactions	ACETYL-COA, AKT, AND, APOPTOSIS, AUTOPHAGY, BIP
KG Connections	71 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ENDOG

gene · 655 words

→

ENDOG Protein (Endonuclease G)

protein · 693 words

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Pathway Diagram

graph TD
    ENDOG["ENDOG"]
    Als{"Als"}
    ENDOG -->|"activates"| Als
    MTORC1["MTORC1"]
    ENDOG -->|"activates"| MTORC1
    BIP["BIP"]
    ENDOG -->|"activates"| BIP
    IRE1A["IRE1A"]
    ENDOG -->|"activates"| IRE1A
    APOPTOSIS["APOPTOSIS"]
    ENDOG -->|"activates"| APOPTOSIS
    AUTOPHAGY["AUTOPHAGY"]
    ENDOG -->|"activates"| AUTOPHAGY
    TSC2["TSC2"]
    ENDOG -->|"activates"| TSC2
    EIF2AK3["EIF2AK3"]
    ENDOG -->|"activates"| EIF2AK3
    GSK3B["GSK3B"]
    ENDOG -->|"activates"| GSK3B
    ERN1["ERN1"]
    ENDOG -->|"activates"| ERN1
    HSPA5["HSPA5"]
    ENDOG -->|"activates"| HSPA5
    ACETYL_COA["ACETYL-COA"]
    ENDOG -->|"activates"| ACETYL_COA
    PIK3C3["PIK3C3"]
    PIK3C3 -->|"activates"| ENDOG
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| ENDOG
    YWHAG["YWHAG"]
    YWHAG -->|"activates"| ENDOG
    RICTOR["RICTOR"]
    RICTOR -->|"activates"| ENDOG
    AKT["AKT"]
    AKT -->|"activates"| ENDOG
    style ENDOG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (55)

Target	Relation	Type	Str
Als	activates	disease	0.65
IRE1A	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
Autophagy	activates	pathway	0.60
Akt	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Mtor	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
AND	activates	gene	0.60
BIP	activates	gene	0.60
TSC2	activates	gene	0.60
EIF2AK3	activates	gene	0.60
GSK3B	activates	gene	0.60
ERN1	activates	gene	0.60
HSPA5	activates	gene	0.60
AKT	activates	gene	0.60
PIK3C3	activates	gene	0.60
RICTOR	activates	gene	0.60
MTORC1	activates	gene	0.60
YWHAG	activates	gene	0.60
DNA	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
MTNR1A	co_discussed	gene	0.50
MYC	co_discussed	gene	0.50
UBIQUITIN	co_discussed	protein	0.50
GASDERMIN	co_discussed	gene	0.50
NLR	co_discussed	gene	0.50
WAS	co_discussed	protein	0.50
LYSOSOME	co_discussed	gene	0.50
PARKINSON	co_discussed	gene	0.50
STROKE	co_discussed	gene	0.50
RNA	co_discussed	gene	0.50
EPILEPSY	co_discussed	gene	0.50
TH PROTEIN	co_discussed	protein	0.50
P53	co_discussed	protein	0.50
GPR37	co_discussed	gene	0.50
PVALB	co_discussed	gene	0.50
SST	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
STING	co_discussed	gene	0.50
GSDMD	co_discussed	protein	0.50
IBA1	co_discussed	protein	0.50
NLRP3	co_discussed	protein	0.50
TGM2	co_discussed	gene	0.50
PINK1	co_discussed	gene	0.50
PTEN	co_discussed	gene	0.50

Incoming (16)

Source	Relation	Type	Str
MITOPHAGY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
PIK3C3	activates	gene	0.60
YWHAG	activates	gene	0.60
RICTOR	activates	gene	0.60
AKT	activates	gene	0.60
ERN1	activates	gene	0.60
PERK	activates	gene	0.60
AMYLOID	co_discussed	gene	0.50
DEMENTIA	co_discussed	gene	0.50
ALZHEIMER	co_discussed	gene	0.50
CANCER	co_discussed	gene	0.50
CYCLIN D1	co_discussed	gene	0.50
APP	co_discussed	gene	0.50
CDKN2B	co_discussed	gene	0.50
C1Q	co_discussed	gene	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Age-Stratified Dosing Protocol Reflecting Endogenous Decline	0.665	-	What is the optimal dosage and timing of
HBOT at 1.5 ATA for 60 min induces hormetic response via Nrf	0.640	neurodegeneration	What are the optimal oxygen pressure, du
Competitive endogenous RNA network modulates mmu-miR-6361 av	0.380	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Competitive endogenous RNA mechanism enables lncRNA-0021 to	0.380	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENDOG in their description or question text

No additional research found