gene 1,739 words KG: MAVS
Contents

MAVS Gene

🧬 Gene Info
Gene SymbolMAVS
Full NameMitochondrial Antiviral Signaling Protein
Chromosome20p13
Protein TypeAdaptor Protein
Functionencodes a critical adaptor protein that serves as the central hub for Rig-I-like receptor (RLR) signaling in the innate immune response.
Primary ExpressionUbiquitous (liver, heart, brain)
Amino Acids540 aa
PathwaysNF-κB
UniProt IDQ9Y2H9
NCBI Gene ID57468
Ensembl IDENSG00000088888
OMIM609588
GeneCardsMAVS
Human Protein AtlasMAVS
Associated DiseasesAging, Infection, Inflammation
Known Drugs/Compoundsrapamycin
InteractionsActin, AGING, AKT, AKT1, AKT1S1, AMBRA1
KG Connections550 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
APOE-Dependent Autophagy Restoration
Score: 0.86
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Microbial Inflammasome Priming Prevention
Score: 0.65

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
Apoptosis in Neurodegeneration
entity · KG edge: activates
Astrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

M2_PROTEIN interacts_with MAVS
ATF6 interacts_with MAVS
OPTN interacts_with MAVS
CASP3 interacts_with MAVS
AKT1 interacts_with MAVS
CALCOCO2 interacts_with MAVS
CGAS interacts_with MAVS
CFTR interacts_with MAVS
SQSTM1 interacts_with MAVS
RPS6KB1 interacts_with MAVS

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